Cerebral venous sinus thrombosis as an initial manifestation of primary antiphospholipid syndrome

Tsai, Chia‐Lin; Hueng, Dueng‐Yuan; Tsao, Wen-Long; Lin, Jiann-Chyun

doi:10.1016/j.ajem.2012.12.020

Cited by 8 publications

(6 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, APS contributes to a significant proportion of CVT cases (6–17% in cohort studies) [ 58 ], and aCL positivity may be found in 7–22% of patients [ 59 , 60 ]. CVT may be the presenting symptom of APS [ 61 ]. Treatment should follow the general guidelines for CVT [ 62 ] and usually includes long-term anticoagulation [ 58 ].…”

Section: Neurological Manifestations Of Apsmentioning

confidence: 99%

Neurologic Manifestations of the Antiphospholipid Syndrome — an Update

Rato

Bandeira

Romão

et al. 2021

Curr Neurol Neurosci Rep

View full text Add to dashboard Cite

Purpose of Review In recent years, the spectrum of neurological manifestations of antiphospholipid syndrome (APS) has been growing. We provide a critical review of the literature with special emphasis on presentation, proposed mechanisms of disease, and treatment of neurological involvement in APS. Recent Findings Although stroke is the most common cause of neurological manifestations in patients with APS, other neurological disorders have been increasingly associated with the disease, including cognitive dysfunction, headache, and epilepsy. Direct oral anticoagulants have failed to show non-inferiority compared to vitamin K antagonists for the prevention of major thrombotic events. Antiphospholipid antibodies are often found in patients with acute COVID-19 but clear evidence supporting an association between these antibodies and the risk of thrombotic events, including stroke and cerebral venous thrombosis, is still lacking. Summary APS patients may present with several distinct neurological manifestations. New criteria will facilitate the classification of patients presenting with increasingly recognized non-criteria neurological manifestations.

show abstract

Section: Neurological Manifestations Of Apsmentioning

confidence: 99%

Neurologic Manifestations of the Antiphospholipid Syndrome — an Update

Rato

Bandeira

Romão

et al. 2021

Curr Neurol Neurosci Rep

View full text Add to dashboard Cite

show abstract

“…La TVC es una complicación poco frecuente del síndrome antifosfolipídico. 5,7 Los mecanismos fisiopatológicos detrás de este padecimiento no se encuentran aún del todo comprendidos, sin embargo estudios previos indican que los anticuerpos antifosfolipídicos promueven un estado protrombótico al potenciar la agregación plaquetaria y la mayor adhesividad por medio de la regulación del tromboxano A2 al incrementarlo; 8 además de promover este estado por medio de la activación de células endoteliales, plaquetas y monocitos. 9 La cefalea en la TVC se encuentra con una prevalencia del 85%, el déficit cognitivo en el 25 %, 9 el incremento de la presión intracraneal en el 15 al 40 % de pacientes, 10 y se describe la presencia de signos de irritación meníngea como parte del cuadro clínico, sin embargo la presencia de defectos visuales descrita hasta en el 40% de pacientes no fue objetivada en el presente caso.…”

Section: Discusión -unclassified

“…4 La positividad del anticoagulante lúpico puede encontrarse en el 7 a 22% de los pacientes con TVC, siendo la TVC una forma de presentación de SAF y su tratamiento es la anticoagulación a largo plazo. 5,6 Se trata del caso de un paciente joven con trombosis de los senos venosos cerebrales, sagital superior y transverso, como forma de presentación de SAF con positividad de anticoagulante lúpico.…”

Section: Introducción -unclassified

Trombosis de los senos venosos como forma de presentación de un síndrome antifosfolipídico

Guzmán-García,

Ruiz Aguirre,

Samaniego Burneo

et al. 2022

RevReumDia

View full text Add to dashboard Cite

El síndrome antifosfolipídico es una enfermedad autoinmune que afecta varios órganos y sistemas; se caracteriza principalmente por presencia de trombos arteriales/venosos en lugares poco usuales y/o la presencia de abortos a repetición, entres otras manifestaciones. La trombosis de los senos venosos cerebrales puede ser una forma de presentación de un síndrome antifosfolipídico, es considerada una entidad rara y poco frecuente en la práctica médica diaria, debuta a cualquier edad, con cierto predominio en la población joven, con una relación mujeres/hombres de 3:1. A propósito, se presenta un caso de un paciente joven con trombosis de los senos venosos cerebrales, sagital superior y transverso derecho, como forma de presentación de un síndrome antifosfolipídico.

show abstract

“…The mechanism is still not fully understood, but it has been speculated that APL promotes the pre-thrombotic state by activating endothelial cells, platelets, and monocytes. In addition, anti-b2GP-1 antibodies and complement activation play an important role in thromboembolism (27).…”

Section: Antiphospholipid Syndrome (Aps)-associated Cvstmentioning

confidence: 99%

Characteristics and Management of Autoimmune Disease-Associated Cerebral Venous Sinus Thrombosis

et al. 2021

View full text Add to dashboard Cite

Cerebral venous sinus thrombosis (CVST) is a central nervous system disease characterised by thrombosis in cerebral venous or dural sinuses. Autoimmune diseases, a series of diseases caused by immune responses to autoantigens, are important causes of CVST. The most common diseases that lead to CVST are Behçet’s syndrome, systemic lupus erythematosus, antiphospholipid syndrome, and Sjögren’s syndrome. Each of these diseases have different clinical and imaging manifestations and treatment for CVST varies by aetiology. This review summarises the characteristics and the current management strategies for autoimmune disease-associated CVST and emphasises controversial therapeutic strategies to provide informative reference information for diagnosis and treatment. Risk factors of autoimmune antigens should not be neglected when unconventional CVST occurs, and both drugs and interventional therapy need further standardisation and discussion with more prospective clinical studies.

show abstract

Cerebral venous sinus thrombosis as an initial manifestation of primary antiphospholipid syndrome

Cited by 8 publications

References 10 publications

Neurologic Manifestations of the Antiphospholipid Syndrome — an Update

Neurologic Manifestations of the Antiphospholipid Syndrome — an Update

Trombosis de los senos venosos como forma de presentación de un síndrome antifosfolipídico

Characteristics and Management of Autoimmune Disease-Associated Cerebral Venous Sinus Thrombosis

Contact Info

Product

Resources

About