Cerebral vasodilatation induced by stimulation of the pterygopalatine ganglion and greater petrosal nerve in anesthetized monkeys

Toda, Noboru; Tanaka, Toshiki; Ayajiki, Kazuhide; Okamura, Tomio

doi:10.1016/s0306-4522(99)00557-6

Cited by 86 publications

(55 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…20 Unilateral denervation of the monkey PPG decreased the diameter of the ipsilateral ACA and MCA. 7 We previously reported that intracisternal injections of L-NA constrict the BA and that this effect is reversed by L-arginine. Furthermore, the vasoconstrictor action of L-NA is significantly attenuated by treatment with hexamethonium, suggesting that neurogenic NO, which is continuously released under resting conditions, is involved in basilar arterial dilatation in anesthetized monkeys and dogs.…”

Section: Discussionmentioning

confidence: 96%

“…The two values were averaged and the results were expressed as a percentage of the control artery diameter obtained just before the electrical stimulation, as described in our previous studies. 7,10 Arterial diameters before, during and 10 min after the nerve stimulation were measured by angiography.…”

Section: In Vivo Studymentioning

confidence: 99%

“…1,2 Histochemistry has showed that nitric oxide synthase (NOS)-containing nerves originating from the pterygoparatine ganglion (PPG) innervate arteries irrigating the cerebrum in many species. [3][4][5][6] We have reported that electrical stimulation of the unilateral PPG or the greater petrosal nerve (GPN), a preganglionic parasympathetic nerve that synaptically connects to the PPG, dilates the ipsilateral anterior cerebral artery (ACA), and the middle cerebral artery (MCA) in anesthetized monkeys 7 and dogs. 8 We have also found that these dilatations are suppressed by a NOS inhibitor.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Nitrergic nerves derived from the pterygopalatine ganglion innervate arteries irrigating the cerebrum but not the cerebellum and brain stem in monkeys

et al. 2011

View full text Add to dashboard Cite

The functional roles of the nitrergic nerves innervating the monkey cerebral artery were evaluated in a tension-response study examining isolated arteries in vitro and cerebral angiography in vivo. Nicotine produced relaxation of arteries by stimulation of nerve terminals innervating isolated monkey arteries irrigating the cerebrum, cerebellum and brain stem. Relaxation of arteries induced by nicotine was abolished by treatment with N G -nitro-L-arginine, a nitric oxide synthase inhibitor, and was restored by addition of L-arginine. Cerebral angiography showed that electrical stimulation of the unilateral greater petrosal nerve, which connects to the pterygopalatine ganglion via the parasympathetic ganglion synapse, produced vasodilatation of the anterior, middle and posterior cerebral arteries in the stimulated side. However, stimulation failed to produce vasodilatation of the superior and anterior-inferior cerebellar arteries and the basilar artery in anesthetized monkeys. Therefore, nitrergic nerves derived from the pterygopalatine ganglion appear to regulate cerebral vasomotor function. In contrast, circulation in the cerebellum and brain stem might be regulated by nitrergic nerves originating not from the pterygopalatine ganglion, but rather from an unknown ganglion (or ganglia).

show abstract

Section: Discussionmentioning

confidence: 96%

Section: In Vivo Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Nitrergic nerves derived from the pterygopalatine ganglion innervate arteries irrigating the cerebrum but not the cerebellum and brain stem in monkeys

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Essentially all of the nitroxidergic innervation of forebrain vessels derives from neurons of the pterygopalatine ganglia , bilateral ganglia that lie near the floor of the orbit and send ganglionic projections into the cranium through the mesial orbital wall (Hara, H. et al, 1993). Stimulation of those ganglia leads to cerebral arterial dilatation (Seylaz, J. et al, 1988;Toda, N. et al, 2000b;Toda, N. et al, 2000a) and some reports, which indicate that interruption of the ganglia or their innervation leads to cerebral vasoconstriction (Toda, N. et al, 2000b;Toda, N. et al, 2000a), suggest that they exert a tonic vasodilator influence. Stimulation of the superior salivatory nucleus (SSN), the site of preganglionic neurons that project to the pterygopalatine ganglia and thus influence CBF, also leads to vasodilatation of cerebral vessels (Agassandian, K. et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

“…There has been little evidence to show how the nitroxidergic parasympathetic influence on cerebral blood vessels may participate in physiological processes in the whole animal although its having been found in so many vertebrate species (Goadsby, P. J. et al, 1996;Kimura, T. et al, 1997;Nozaki, K. et al, 1993;Toda, N. et al, 2000b;Yu, J. G. et al, 1997) certainly suggests that it might serve an important role. In fact, some reports have suggested both pathophysiologic as well as physiologic involvement of the pathway.…”

Section: Discussionmentioning

confidence: 99%

Neuronal nitric oxide mediates cerebral vasodilatation during acute hypertension

Talman

Dragon

2007

Brain Research

View full text Add to dashboard Cite

Parasympathetic nerves from the pterygopalatine ganglia provide nitroxidergic innervation to forebrain cerebral blood vessels. Disruption of that innervation attenuates cerebral vasodilatation seen during acute hypertension as does systemic administration of a non-selective nitric oxide synthase (NOS) inhibitor. Although such studies suggest that nitric oxide (NO) released from parasympathetic nerves participates in vasodilatation of cerebral vessels during hypertension that hypothesis has not been tested with selective local inhibition of neuronal NOS (nNOS). We tested that hypothesis through these studies performed in anesthetized rats instrumented for continuous measurement of blood pressure, heart rate and pial arterial diameter through a cranial window. We sought to determine if the nNOS inhibitor propyl-L-arginine delivered directly to the outer surface of a pial artery would 1) attenuate changes in pial arterial diameter during acute hypertension and 2) block nNOS mediated dilator effects of N-methyl-D-Aspartate (NMDA) delivered into the window but 3) not block vasodilatation elicited by acetylcholine (ACh) and mediated by endothelial NOS dilator. Without the nNOS inhibitor arterial diameter abruptly increased 70 ± 15% when mean arterial pressure (MAP) reached 183 ± 3 mmHg while with nNOS inhibition diameter increased only 13 ± 10% (p<0.05) even when MAP reached 191 ± 4 (p>0.05). The nNOS inhibitor significantly attenuated vasodilatation induced by NMDA but not ACh delivered into the window. Thus, local nNOS inhibition attenuates breakthrough from autoregulation during hypertension as does complete interruption of the parasympathetic innervation of cerebral vessels. These findings further support the hypothesis that NO released from parasympathetic fibers contributes to cerebral vasodilatation during acute hypertension. Section: Regulatory Systems

show abstract

Phylogenesis of constitutively formed nitric oxide in non-mammals

Toda¹,

Ayajiki²

2006

Reviews of Physiology Biochemistry and Pharmacology

View full text Add to dashboard Cite

Cerebral vasodilatation induced by stimulation of the pterygopalatine ganglion and greater petrosal nerve in anesthetized monkeys

Cited by 86 publications

References 18 publications

Nitrergic nerves derived from the pterygopalatine ganglion innervate arteries irrigating the cerebrum but not the cerebellum and brain stem in monkeys

Nitrergic nerves derived from the pterygopalatine ganglion innervate arteries irrigating the cerebrum but not the cerebellum and brain stem in monkeys

Neuronal nitric oxide mediates cerebral vasodilatation during acute hypertension

Phylogenesis of constitutively formed nitric oxide in non-mammals

Contact Info

Product

Resources

About