Cerebral Vascular Resistance in Premature Infants

Daven, Joel R.; Milstein, Jerrold M.; Guthrie, Robert D.

doi:10.1001/archpedi.1983.02140300010003

Cited by 15 publications

(6 citation statements)

References 21 publications

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“…These results are similar to fetal 'brain-sparing' effects (Campbell et al 1967;Peeters et al 1979;Sheldon et al 1979) that are presumed to preserve vital homeostasis during hypoxia in utero (Pearce, 2006;Salihagić-Kadić et al 2006). Similar effects have also been shown in newborn dogs (Cavazzuti & Duffy, 1982), piglets (Goplerud et al 1989) and premature infants (Daven et al 1983). The largest response to hypoxia tends to occur in the brainstem during the early postnatal period and decreases with age (Bilger & Nehlig, 1993).…”

Section: Brain Sparingsupporting

confidence: 78%

AltitudeOmics: effect of ascent and acclimatization to 5260 m on regional cerebral oxygen delivery

Subudhi

Fan

Evero

et al. 2014

Experimental Physiology

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Section: Brain Sparingsupporting

confidence: 78%

AltitudeOmics: effect of ascent and acclimatization to 5260 m on regional cerebral oxygen delivery

Subudhi

Fan

Evero

et al. 2014

Experimental Physiology

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“…Bearing above mentioned considerations in mind our study underiines the findings of other cIinical studies that severe hypercarbia causes a decreased cerebrovascular resistance and increased cerebral blood flow in the preterm infant as indicated by a lower PI of the ACA during severe hypercarbia, in spite ofthe AUVC which did not change significantly (3,4,11,25). The decrease of cerebrovascular resistance is said to be mainly caused by a carbon dioxideinduced vasodilatation ofthe cerebral arterioies (16,19,23).…”

Section: Discussionsupporting

confidence: 65%

The Influence of Abnormal Blood Gases on Cerebral Blood Flow Velocity in the Preterm Newborn

M²,

Baan³

et al. 1988

Neuropediatrics

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The influence of hypercarbia, combined hypercarbia and hypoxemia, and hypocarbia on cerebral blood flow of preterm infants with a gestational age of less than 34 weeks was investigated by measuring peak systolic flow velocity (PSFV), end diastolic flow velocity (EDFV), pulsatility index (PI) and area under the velocity curve (AUVC) ofthe anterior cerebral artery (ACA) using transcutaneous Doppler technique. Mild and moderate hypocarbia did not change cerebral blood flow velocity. During severe hypercarbia (PaC0 2 6.7 kPa) significantly lower PI-values were detected, mainly caused by an increase of EDFV, indicating a decreased cerebrovascular resistance and increased cerebral blood flow. A highly significant decrease in PI-values during combined severe hypercarbia and hypoxemia (Pa0 2 < 6.0 kPa) was found suggesting that hypoxemia superimposed on hypercarbia strengthens the increase of cerebral blood flow. While the increase of EDFV is thought to be due to carbon dioxide-induced vasodilation ofcerebral arterioles, we assume that the accompanied increase of PSFV during combined hypercarbia and hypoxemia is caused by an increase in cardiac output due to hypoxemia which can alter the blood flow velocity wave form ofthe ACA.

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“…We studied the relation between cerebral blood-flow velocity and Pacoz and were unable to show an over-all correlation, but found a positive relationship between cerebral blood-flow velocity and Pacoz levels above 6.7k~a ( = S O mmHg) (unpublished data). This is supported by earlier studies which indicate that hypercarbia causes vasodilatation of cerebral arterioles and a subsequent increment of cerebral blood-flow (Huber and Handa 1967, Greenberg et al 1978, Daven et al 1983, Jorch and Menge 1985, Archer et af. 1986.…”

Section: Discussionsupporting

confidence: 67%

Aetiological Rôle Of Cerebral Blood‐Flow Alterations In Development And Extension Of Peri‐Intraventricular Haemorrhage

Bel

Bor

Stijnen

et al. 1987

Develop Med Child Neuro

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SUMMARY The aetiology and extension of peri‐intraventricular haemorrhage (PIVH) are thought to be related to cerebral blood‐flow alterations, and especially to increased cerebral blood‐flow and fluctuating velocity of blood‐flow. Using transcutaneous Doppler technique, the authors investigated cerebral blood‐flow in 60 infants with gestations of less than 34 weeks. Pulsatility index (PI) and area under the velocity curve (AUVC) of the anterior cerebral arteries (ACA) were used as qualitative measures of cerebral blood‐flow, and the coefficient of variation of PI and AUVC as indicators of fluctuations in blood‐flow velocity. A reasonable correlation was found between PI and AUVC and their coefficients of variation in the ACA. First onset of PIVH was related to fluctuating blood‐flow velocity, and extension of PIVH with both increased velocity (indicating increased blood‐flow) and fluctuating velocity. Increased cerebral blood‐flow and its fluctuating pattern were positively correlated with arterial carbon dioxide tension. RESUME Le rôle étiologique des altérations de la circulation sanguine cérébrale dans le développement et ľextension de ľhémorragie péri‐intra‐ventriculaire On estime que ľétiologie et ľextension de ľhémorragie péri‐intra‐ventriculaire (PIVH) sont liées à des altérations de la circulation sanguine cérébrale et spécialement à un accroissement de cette circulation et à des fluctuations dans la vitesse de circulation sanguine. Utilisant la technique du Doppler transcutané, les auteurs ont étudié la circulation sanguine cérébrale chez 60 nourrissons avec des durées de gestation de moins de 34 semaines. L'index de pulsatilité (PI) et la surface comprise sous la courbe de vitesse circulatoire (AUMC) des artères cérébrales antérieures (ACA) ont été utilisés comme mesures qualitatives de la circulation sanguine cérébrale et le coefficient de variation de PI et AUVC comme indicateur de fluctuations dans la vitesse circulatoire. Une correlation raisonnable a été trouvée entre PI et AUVC et leur coefficient de variation dans les ACA. La premiére manifestation de PIVH était reliée à une vitesse circulatoire fluctuante et ľextension de la PIVH à la fois à une vitesse accrue (indiquant une circulation accrue) et une vitesse fluctuante. La circulation cérébrale sanguine accrue et ses patterns de fluctuations étaient positivement corrélés à la pression artérielle de dioxide de carbone. ZUSAMMENFASSUNG Die aetiologische Rolle cerebraler Blutströmungsveränderungen für die Entwicklung und Ausdehnung peri‐intraventrikulärer Blutungen Es wird angenommen, daß die Aetiologie und Ausdehnung von peri‐intraventrikulären Blutungen (PIVH) mit Veränderungen des cerebralen Blutstroms und insbesondere mit erhótem cerebralem Blutstrom und fluktuierender Blutstromgeschwindigkeit zusammenhängen. Unter Verwendung der transcutanen Doppler Technik haben die Autoren den cerebralen Blutstrom bei 60 Säuglingen mit einem Gestationsalter unter 34 Wochen untersucht. Der Pulsatilitätsindex (PI) und die Fläche unter der Geschwindigkeitskurve...

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Cerebral Vascular Resistance in Premature Infants

Cited by 15 publications

References 21 publications

AltitudeOmics: effect of ascent and acclimatization to 5260 m on regional cerebral oxygen delivery

AltitudeOmics: effect of ascent and acclimatization to 5260 m on regional cerebral oxygen delivery

The Influence of Abnormal Blood Gases on Cerebral Blood Flow Velocity in the Preterm Newborn

Aetiological Rôle Of Cerebral Blood‐Flow Alterations In Development And Extension Of Peri‐Intraventricular Haemorrhage

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