Cerebral thromboembolic events in pediatric patients with inflammatory bowel disease

Barclay, Allan G.; Keightley, Jaclyn; Horrocks, Iain; Garrick, Vikki; McGrogan, Paraic; Russell, R. K.

doi:10.1002/ibd.21113

Cited by 36 publications

(20 citation statements)

References 45 publications

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“…Mean diagnosis age of the reported 20 cases was 11.7 ± 2.7 years and median value of time to development of CSVT after diagnosis of UC was 10.5 months [ranging 0.5-66.0 months] (Table I). The earliest time to development of thrombosis during disease progression was two weeks as reported by Barclay et al (7). The longest time to development of CSVT after UC was 66 months (5).…”

Section: Demographic Findingssupporting

confidence: 51%

A Significant Association in Paediatric Emergency Department, Cerebral Sinovenous Thrombosis and Ulcerative Colitis: Review of Literature

Açıkgöz¹,

Guzel²,

Aslan³

et al. 2016

West Indian Med J

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Aim: To discuss cerebral sinovenous thrombosis (CSVT), which is an important mortality and morbidity factor developing in progression of ulcerative colitis (UC) in childhood age, in the light of literature. Materials and Methods: A review has been performed on database of Pubmed and Google Scholar Search on April 2014. The study retrospectively investigated the cases diagnosed UC with complication of CSVT below 18 years of age between years 1971 to 2014. The cases were analysed with respect to age, gender, disease duration and treatment, potential risk factors, clinical findings, location of thrombosis, thrombolytic therapeutical applications and clinical progressions. Results: Twenty four paediatric cases aged between five and 18 years were included in the study. Cerebral sinovenous thrombosis had developed during active disease period in 23 (95.8%) periods. The most common application rationales were headache (79.1%) and emesis (29.1%). The most frequently detected risk factors for CSVT were anaemia (58.3%) and thrombocytosis (45.8%). Inherited thrombotic disorders were encountered 10 (41.6%) cases. The most common location sites for CSVT were transverse (33.3%) and sigmoid (33.3%) sinuses. It has been encountered that 19 (79.2%) cases were healed completely without a sequela whereas neurological sequelae remained in 3 (12.5%) cases and 2 (8.3%) cases died. Conclusion: When a paediatric patient diagnosed with UC within apply emergency service with emesis, headache and mood changes during especially seizure; presence of CSVT should be certainly considered.

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Section: Demographic Findingssupporting

confidence: 51%

A Significant Association in Paediatric Emergency Department, Cerebral Sinovenous Thrombosis and Ulcerative Colitis: Review of Literature

Açıkgöz¹,

Guzel²,

Aslan³

et al. 2016

West Indian Med J

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“…75 Recently, it has been suggested starting LMWH in children with IBD ''and additional risk,'' as inpatient/immobilized, thrombophilia, thrombocytosis >750/mm dypiridamol) was suggested for selected ''additional risk'' patients. 15 Some general recommendations on the management of TE in children with IBD are given in Table 6. Based on the existing body of research it is difficult to provide more specific advice for pharmacoprophylaxis in children.…”

Section: Discussionmentioning

confidence: 99%

Thromboembolism in pediatric inflammatory bowel disease: Systematic review

Lazzerini¹,

Bramuzzo²,

Maschio³

et al. 2011

Inflammatory Bowel Diseases

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“…This is particularly important as patients with IBD and undernutrition are more likely to present higher levels of adiposity, for the same unit of BMI as healthy controls, are more prone to cardiovascular diseases [26,27] and undernutrition can affect adversely their quality of life and clinical outcomes [28]. In this study, percentage weight loss was determined using the current and last recorded weight.…”

Section: Discussionmentioning

confidence: 99%

A multicentre Study of Nutrition Risk Assessment in Adult Patients with Inflammatory Bowel Disease Attending Outpatient Clinics

et al. 2018

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Background: Overnutrition and undernutrition can affect patients with inflammatory bowel disease (IBD). Although all IBD outpatients should be screened for nutrition risk, screening is not routinely performed, potentially leading to reduced identification and treatment. This study aimed to estimate the prevalence of nutrition risk in adult IBD outpatients and the proportion of cases who discussed diet and/or nutrition during their routine clinical appointment. Methods: Adults with IBD attending outpatient clinics at 4 hospitals in Greece and in UK were recruited. Demographic and anthropometric data were collected using face-to-face patient interviews and clinical records. Patients were classified as high (i.e., body mass index [BMI] < 18.5 or 18.5–20 kg/m² and weight loss > 5%), moderate (i.e., BMI 20–25 kg/m² and weight loss > 5%) or low risk of undernutrition and high risk of obesity (i.e., BMI 25–30% and weight gain > 5%). The proportion of patients who discussed diet and/or nutrition during their clinical appointment was calculated. Results: In total, 390 IBD patients participated. Sixteen (4%) patients were underweight, 113 (29%) were overweight and 71 (18%) were obese. Twenty-one (5%) patients were at high risk of undernutrition; of these 4 (19%) were under dietetic care. Of those at high risk of undernutrition, 11 (52%) had discussed diet and/or nutrition during their routine clinical appointment. Fifty-six (14%) patients had gained more than 5% weight since their last recorded/reported weight and 19 (5%) were at high risk of obesity. Conclusions: Few patients were identified to be at high risk of undernutrition and less than a fifth of these were under dietetic care. Overnutrition is a growing problem in IBD with almost half of adult patients being overweight or obese. Diet and/or nutrition were not routinely discussed in this group of IBD outpatients.

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Cerebral thromboembolic events in pediatric patients with inflammatory bowel disease

Cited by 36 publications

References 45 publications

A Significant Association in Paediatric Emergency Department, Cerebral Sinovenous Thrombosis and Ulcerative Colitis: Review of Literature

A Significant Association in Paediatric Emergency Department, Cerebral Sinovenous Thrombosis and Ulcerative Colitis: Review of Literature

Thromboembolism in pediatric inflammatory bowel disease: Systematic review

A multicentre Study of Nutrition Risk Assessment in Adult Patients with Inflammatory Bowel Disease Attending Outpatient Clinics

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