Cerebral Resuscitation from Temporary Complete Global Brain Ischemia

Šafář, Peter

doi:10.1007/978-3-642-56036-1_9

Cited by 4 publications

(4 citation statements)

References 221 publications

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“…ECPR for refractory cardiopulmonary arrest can be applied for the purpose of supporting a patient for cerebral-cardiopulmonary resuscitation (cerebral-CPR) ( 19 ) or for the purpose of supporting organs for donation ( 20 ). This paper focuses on using ECPR for cerebral-CPR.…”

Section: Patient Selectionmentioning

confidence: 99%

Establishing and Sustaining an ECPR Program

Laussen

Guerguerian

2018

Front. Pediatr.

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The use of extracorporeal support after failed return of a spontaneous ciruculation during cardiopulmonary resuscitation (ECPR) is well described. There are 4 distinct phases for resuscitation with ECPR and the time spent in each phase is critical for successful outcome. Recommendations for ECPR previously published by the American Heart Association provide the context for implementing a consistent and well-rehearsed system for ECPR, by people with the knowledge, experience and resources to deploy ECPR in the most optimal time frame possible in selected patient populations. In this manuscript we review the current status of ECPR for acute cardiac failure and the components we believe are necessary to develop and sustain a reliable and resilient program.

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Section: Patient Selectionmentioning

confidence: 99%

Establishing and Sustaining an ECPR Program

Laussen

Guerguerian

2018

Front. Pediatr.

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“…Induced hypothermia has been studied as a means to protect the brain from ischemia Hypoxia: deficiency of oxygen in tissues since the 1940s (2)(3)(4)(5)(6)(7)(8)(9)(10). Resuscitative cerebral hypothermia was introduced first in cardiac arrest for cerebral resuscitation in the 1950s (11). Later research focused on maximization of the ability of the brain tissue to survive anoxic no-flow states as enhanced by hypothermia.…”

Section: History Of Hypothermia Treatment In Medicinementioning

confidence: 99%

Hypothermia Therapy for Brain Injury

Diller

Zhu

2009

Annu. Rev. Biomed. Eng.

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Induced hypothermia is an acknowledged useful therapy for treating conditions that lead to cell and tissue damage caused by ischemia, including traumatic brain injury, stroke, and cardiac arrest. An accumulating body of clinical evidence, together with several decades of research, has documented that the efficacy of hypothermia is dependent on achieving a reduced temperature in the target tissue before or soon following the ischemia-precipitating event. The temperature must be lowered to within a rather small range of values to effect therapeutic benefit without introducing collateral problems. Rewarming must be much slower than cooling. Many different methods and devices have been used for cooling, with mixed results. There are existing opportunities for bioengineers to improve our understanding of the mechanisms of hypothermia and to develop more effective methods of cooling the brain following trauma.

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“…Lowering the temperature of the neurons of the central nervous system causes the development of metabolic depression in them, which leads to a decrease in oxygen consumption, increased resistance to hypoxia, ischemia and reperfusion [7,8]. In general, the following mechanisms of the neuroprotective action of therapeutic hypothermia are currently distinguished: inhibition of destructive enzymatic reactions; inhibition of free radical reactions; plasticity protection of lipoproteins of cytoplasmic membranes; reduced oxygen consumption in areas of the brain with low blood flow; improving oxygen delivery to the ischemic zones of the brain and reducing intracranial pressure; inhibition of biosynthesis and production of exitotoxic neurotransmitters [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Thermoelectric device for contact cooling of the human eye

Анатычук

Pasyechnikova

Науменко

et al. 2020

PCSS

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The paper presents the results of the development of a thermoelectric device in the form of a monocular dressing for contact cooling of the human eye through the eyelids. The developed device allows controlled local contact cooling of the eye structures through the eyelids and is designed to treat the acute and chronic eye diseases, reduce intraocular pressure, and reduce pain and inflammatory processes of the eye. The design features of the device and its technical characteristics are presented.

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Cerebral Resuscitation from Temporary Complete Global Brain Ischemia

Cited by 4 publications

References 221 publications

Establishing and Sustaining an ECPR Program

Establishing and Sustaining an ECPR Program

Hypothermia Therapy for Brain Injury

Thermoelectric device for contact cooling of the human eye

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