Cerebral responses to laser pain stimulus measured using positron emission tomography

Derbyshire, Swg; Jones, Akp; Clarke, Stéphanie; Townsend, David W.; Gyulai, Ferenc; Firestone, Leonard L.; Mintun, M. A.; Jayson, M. I. V.

doi:10.1016/s1053-8119(96)80329-6

“…As in the present study, a thermode was used to present the stimuli, and the position remained constant throughout the scan. In a similar PET study, Derbyshire et al [1996] reported no activation of anterior parietal fields during painful laser stimulation when compared to nonnoxious levels of stimulation. In both of these studies, the thermal stimuli contained no mechanical component.…”

Section: Somatosensory Cortex Activationmentioning

confidence: 93%

“…However, electrophysiological recording results suggest that adaptation should not be a factor [Kenshalo and Isensee, 1983], and the results of the present study do not show a marked adaptation effect, although the results were not conclusive. Further, in the PET study by Derbyshire et al [1996] where laser stimulation was used, 1-msec heat pulses were delivered every 2 sec, reducing the likelihood that adaptation had occurred.…”

Section: Somatosensory Cortex Activationmentioning

confidence: 99%

“…Although imaging technology is advancing rapidly, the role of the somatosensory cortex in pain perception is still controversial [Roland, 1992;Stea and Apkarian, 1992;Backonja, 1996a,b;Kenshalo, 1996;Caselli, 1996;Apkarian, 1996], and the conclusions drawn using these new methods seem contradictory. Many studies have shown cortical activation in response to painful stimuli [e.g., Talbot et al, 1991;Casey et al, 1994;Coghill et al, 1994;Apkarian et al, 1992], while others have not [Jones et al, 1991;Derbyshire et al, 1996] (see also Table I).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Somatosensory cortex: A comparison of the response to noxious thermal, mechanical, and electrical stimuli using functional magnetic resonance imaging

Disbrow

¹

,

Buonocore

²

,

Antognini

³

et al. 1998

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In the present study, functional magnetic resonance imaging (fMRI) was used to examine pain perception in humans. Three types of noxious stimuli were presented: electric shock (20.8 mA, 2 Hz), heat (48 degrees C), and mechanical, as well as a control tactile stimulus. The significance of activation at the level of the voxel was determined using correlation analysis. Significant region of interest (ROI) activation was determined by comparing the percentage of active voxels in each ROI to activation in a control ROI in the visual cortex. In response to tactile and shock stimuli, consistent activation was seen in the postcentral gyrus, parietal operculum, and ipsilateral cerebellar cortex. No significant cortical activation was detected in response to noxious heat or mechanical stimulation when compared to nonpainful intensity levels. The data did not indicate adaptation, although further study in this area is necessary. Stationary noxious thermal and mechanical stimulation are "pure" noxious stimuli, while electrical stimulation influenced nociceptive and nonnociceptive receptors. Lack of detectable activation in response to pure noxious stimuli supports the idea that nociceptive and nonnociceptive fibers are interspersed in the somatosensory cortex. Conflicting results from recent functional imaging studies of pain perception regarding cortical activation indicate that it is essential to consider both the tactile and nociceptive components of the stimuli used, the spatial extent of stimulation, and the possibility of adaptation to the response. Furthermore, these results suggest that subtractive or correlative methods may not be sufficiently sensitive to image the activity of nociceptive cells, which are sparsely distributed throughout the somatosensory cortex.

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“…Those studies in which the stimulus was stationary would be more likely to suffer from this confounding factor. Further, in the PET study by Derbyshire et al [1996] where laser stimulation was used, 1-msec heat pulses were delivered every 2 sec, reducing the likelihood that adaptation had occurred. Further, in the PET study by Derbyshire et al [1996] where laser stimulation was used, 1-msec heat pulses were delivered every 2 sec, reducing the likelihood that adaptation had occurred.…”

Section: Somatosensory Cortex Activationmentioning

confidence: 99%

Somatosensory cortex: A comparison of the response to noxious thermal, mechanical, and electrical stimuli using functional magnetic resonance imaging

Disbrow

¹

,

Buonocore

²

,

Antognini

³

et al. 1998

View full text Add to dashboard Cite

In the present study, functional magnetic resonance imaging (fMRI) was used to examine pain perception in humans. Three types of noxious stimuli were presented: electric shock (20.8 mA, 2 Hz), heat (48 degrees C), and mechanical, as well as a control tactile stimulus. The significance of activation at the level of the voxel was determined using correlation analysis. Significant region of interest (ROI) activation was determined by comparing the percentage of active voxels in each ROI to activation in a control ROI in the visual cortex. In response to tactile and shock stimuli, consistent activation was seen in the postcentral gyrus, parietal operculum, and ipsilateral cerebellar cortex. No significant cortical activation was detected in response to noxious heat or mechanical stimulation when compared to nonpainful intensity levels. The data did not indicate adaptation, although further study in this area is necessary. Stationary noxious thermal and mechanical stimulation are "pure" noxious stimuli, while electrical stimulation influenced nociceptive and nonnociceptive receptors. Lack of detectable activation in response to pure noxious stimuli supports the idea that nociceptive and nonnociceptive fibers are interspersed in the somatosensory cortex. Conflicting results from recent functional imaging studies of pain perception regarding cortical activation indicate that it is essential to consider both the tactile and nociceptive components of the stimuli used, the spatial extent of stimulation, and the possibility of adaptation to the response. Furthermore, these results suggest that subtractive or correlative methods may not be sufficiently sensitive to image the activity of nociceptive cells, which are sparsely distributed throughout the somatosensory cortex.

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Examination of the role of the cerebral cortex in the perception of pain using functional magnetic resonance imaging

Disbrow

¹

,

Baron

²

,

Baron

³

1999

Current Review of Pain

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In the following review we outline several of the unique difficulties associated with designing and interpreting functional imaging studies of pain perception. Unlike other sensory modalities, the cortical processing of pain is unique, as is the pain experience itself. Unlike other sensory systems, pain processing does not take place in one dedicated region of the cortex. Rather, nociceptive cells are sparsely distributed through the somatosensory cortex. Further, pain is singular in that it has both sensory-discriminative and affective-motivational components, which are probably subserved by different neuroanatomic substrates. Finally, abnormal pain sensation, such as neuropathic pain syndromes, may have different or additional mechanisms that require special consideration. We have illustrated these points with examples from our own work on acute pain and secondary mechanical hyperalgesia, and work from other laboratories.

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Cerebral responses to laser pain stimulus measured using positron emission tomography

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Somatosensory cortex: A comparison of the response to noxious thermal, mechanical, and electrical stimuli using functional magnetic resonance imaging

Somatosensory cortex: A comparison of the response to noxious thermal, mechanical, and electrical stimuli using functional magnetic resonance imaging

Somatosensory cortex: A comparison of the response to noxious thermal, mechanical, and electrical stimuli using functional magnetic resonance imaging

Examination of the role of the cerebral cortex in the perception of pain using functional magnetic resonance imaging

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