Cerebral Primitive Neuroectodermal Tumor in an Adult Male

Masuda, Kazuyoshi; Yutani, Chikao; Akutagawa, Kazuhiko; Yamamoto, Shuichi; Hatsuyama, Hiroyuki; Ishibashi‐Ueda, Hatsue; Imakita, Masami; Manaka, Hiroshi; Takahashi, J.; Nagata, Izumi

doi:10.1159/000328596

Cited by 7 publications

(11 citation statements)

References 12 publications

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“…Other cytologic findings consistent with PNET include hyperchromatic nuclei and indistinct nucleoli. Homer‐Wright rosettes, which are radial arrangement of cells around a clear central space recognized on histologic sections, are rarely seen, and neuropil and ganglion cells typically are not present . Although not identified in this case, it is possible that Homer‐Wright rosettes may be found in cytologic preparations, as they have been recognized histologically in reported cases of canine PNETs …”

Section: Discussionmentioning

confidence: 75%

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Cytologic and immunohistochemical characterization of a primitive neuroectodermal tumor in the brain of a dog

Choi

Labelle²,

Alleman

et al. 2012

Veterinary Clinical Pathol

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A 6-year-old intact female Pointer dog was presented for evaluation of acute onset of ataxia, circling, and head tilt. Neurologic assessment revealed overall decreased postural reaction, left-sided hemiparesis with incoordination, rigidity of fore- and hindlimbs, strabismus of the right eye, and bilateral horizontal nystagmus. Using magnetic resonance imaging, a mass lesion was identified in the cerebrum adjacent to the left side of the cerebellum compressing the brain stem ventrally. The mass was incompletely resected, and during surgery fine-needle aspiration and biopsy of the mass were performed. Cytologically, smears were highly cellular and contained predominantly small to medium-sized discrete round cells with high nuclear to cytoplasmic ratios and round nuclei with rare deep clefts or indentation, smooth chromatin, and indistinct nucleoli. Numerous cytoplasmic fragments were noted in the background. The primary diagnosis was lymphoma; other differential diagnoses included neuroendocrine tumor and poorly differentiated tumor of neural origin. The histologic diagnosis was lymphoma, and the lesion was presumed to be metastatic. On immunohistochemical analysis, the cells expressed neither CD3 nor CD79a. Re-examination of the histologic section revealed disorganized sheets of cells with multifocal palisading and perivascular arrangements of rosette-like structures. An expanded panel of antibodies to vimentin, cytokeratin, glial fibrillary acid protein (GFAP), neuron-specific enolase (NSE), synaptophysin (SYN), S-100, and CD45 was applied to histologic sections. Neoplastic cells were immunoreactive for vimentin, NSE, and S-100. Based on the histologic appearance and immunophenotype of the tumor, a diagnosis of primitive neuroectodermal tumor (PNET) was made. PNET, although rare in dogs, should be considered as a differential diagnosis for round cell tumors in the brain.

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Section: Discussionmentioning

confidence: 75%

“…Central PNET can be cerebellar (medulloblastoma) or non‐cerebellar . In people, central PNET is reported most frequently in children or young adults, and rarely in older adults . PNETs have been reported in a monkey, dog, and cat and in cattle .…”

Section: Discussionmentioning

confidence: 99%

Cytologic and immunohistochemical characterization of a primitive neuroectodermal tumor in the brain of a dog

Choi

Labelle²,

Alleman

et al. 2012

Veterinary Clinical Pathol

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“…12) The latest WHO classification includes the terms neuroblastoma, ganglioneuroblastoma, and ependymoblastoma, so diagnosis of a tumor as PNET depends on excluding the other blue cell tumors with distinct differentiation. 14,17,20,25) Both immunohistochemical and ultrastructural studies are useful for examining the differentiation of tumor cells, 14,17) as in our case. Neuronal differentiation was suggested by the presence of neurosecretory granules in the cytoplasm of tumor cells.…”

Section: Discussionmentioning

confidence: 80%

“…However, the findings in our case did not support a diagnosis of neuroblastoma since Homer-Wright rosettes were rare and incomplete, staining for neurofilament protein was negative, and synaptic formation was absent. 14,20,25) The diagnosis of anaplastic astrocytoma was not feasible because GFAP-positive cells were sparse and the labeling index for Ki-67 was too high, and glial filaments were not prominent on electron micrography. 5,20) Malignant lymphoma was ruled out because of the negative immunoreactivity for LCA, CD20, or UCHL1.…”

Section: Discussionmentioning

confidence: 99%

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Supratentorial Primitive Neuroectodermal Tumor in an Aged Patient-Case Report-

Shingu

Kagawa

Kimura

et al. 2005

Neurol. Med. Chir.(Tokyo)

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An 88-year-old woman presented with a supratentorial primitive neuroectodermal tumor (PNET) manifesting as disturbance of consciousness and left hemiplegia. Magnetic resonance imaging showed a large mass lesion in the right frontotemporal region. She underwent biopsy of the lesion that confirmed the diagnosis of PNET. Her poor condition only allowed chemotherapy with methyl 6-[3-(2-chloroethyl)-3-nitrosoureido]-6-deoxy-a-D-glucopyranoside (MCNU), vincristine, and prednisolone to be performed. The patient died approximately 6 months after diagnosis due to enlargement of the tumor. Supratentorial PNET is a rare tumor, especially in adults. Multimodal therapy consisting of gross total or subtotal resection, radiation therapy, and chemotherapy is generally considered necessary for patients with supratentorial PNET. However, the condition of each patient should be considered in determining the therapeutic plan, especially in the case of extremely aged patients, since supratentorial PNET is malignant and long-term survival is rare despite aggressive treatment.

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The Supratentorial Mass in an Adult

Welsh

Smith

2011

Intra-Operative Neuropathology for the Non-Neuropathologist

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Cerebral Primitive Neuroectodermal Tumor in an Adult Male

Cited by 7 publications

References 12 publications

Cytologic and immunohistochemical characterization of a primitive neuroectodermal tumor in the brain of a dog

Cytologic and immunohistochemical characterization of a primitive neuroectodermal tumor in the brain of a dog

Supratentorial Primitive Neuroectodermal Tumor in an Aged Patient-Case Report-

The Supratentorial Mass in an Adult

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