Cerebral pilocytic astrocytoma

Clark, Gary B.; Henry, Jack; McKeever, Paul E.

doi:10.1002/1097-0142(19850901)56:5<1128::aid-cncr2820560529>3.0.co;2-j

Cited by 72 publications

(30 citation statements)

References 10 publications

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“…Similarly, a number of studies have indicated that patients who have JPA have a survival advantage compared with patients who have FA. 34,[42][43][44][45][46] In contrast, in a study of 142 children with low-grade astrocytoma, Gajjar et al 33 found no relation between tumor histology (JPA vs. astrocytoma, not otherwise diagnosed) and PFS in an analysis that controlled for age and anatomic site.…”

Section: Factors Affecting Outcomementioning

confidence: 99%

Outcome of children with centrally reviewed low‐grade gliomas treated with chemotherapy with or without radiotherapy on Children's Cancer Group high‐grade glioma study CCG‐945

Fouladi

Hunt

Pollack

et al. 2003

Cancer

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BACKGROUNDThe objectives of the current study were to determine the outcome of children who were treated with chemotherapy and radiotherapy on the Children's Cancer Group (CCG) high‐grade glioma protocol (CCG‐945) who were diagnosed with low‐grade gliomas on post hoc central pathologic review and to identify clinical and biologic features associated with prognosis.METHODSBetween 1985 and 1991, 250 children with institutionally classified high‐grade gliomas were enrolled on CCG‐945. Patients older than 24 months with intracranial lesions were assigned randomly to receive either lomustine, vincristine, and prednisone (control regimen) or the 8‐drugs‐in‐1‐day regimen (experimental regimen); younger patients and those with primary spinal cord tumors were assigned nonrandomly to the experimental regimen. Central independent review by 5 neuropathologists led to a reclassification of low‐grade glioma in 70 patients, who were the focus of the current study.RESULTSThe study involved 42 males and 28 females (median age, 7.7 years) with a median follow‐up of 10.4 years. At 5 years, the progression‐free survival (PFS) rate was 63% ± 6%, and the overall survival (OS) rate was 79% ± 5%, compared with a PFS rate of 19% ± 3% (P < 0.0001) and an OS rate of 22% ± 3% (P < 0.0001) in the remainder of the cohort. Significantly poorer 5‐year PFS was seen in children younger than 24 months, those with fibrillary astrocytoma, and those with posterior fossa tumors. Patients demonstrated a modest improvement in PFS but no improvement in OS compared with children with low‐grade gliomas who were treated with contemporary chemotherapy‐alone approaches.CONCLUSIONSThe current report calls attention to the importance of central pathologic review in large multiinstitutional trials of children with gliomas and suggests that aggressive front‐line combined chemoradiotherapy does not confer a survival advantage in this highly selected population of patients. Cancer 2003;98:1243–52. © 2003 American Cancer Society.DOI 10.1002/cncr.11637

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Section: Factors Affecting Outcomementioning

confidence: 99%

Outcome of children with centrally reviewed low‐grade gliomas treated with chemotherapy with or without radiotherapy on Children's Cancer Group high‐grade glioma study CCG‐945

Fouladi

Hunt

Pollack

et al. 2003

Cancer

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“…10,29,35) In a series of supratentorial pilocytic astrocytomas, 9% to 20% of cases showed recurrence within 6-12 years. 1,9,14,30) Since late recurrences of cerebellar pilocytic astrocytoma 36 and 45 years after``complete'' surgical resection have been reported, late recurrence could also occur in patients with supratentorial pilocytic astrocytoma. 4,29) Three patterns of recurrence can be described: early recurrence, within 4 years of initial surgery, which is more likely to be associated with younger age and diffuse histological appearance; late recurrence, which is unrelated to histological features and the extent of surgery and apparently unpredictable; and late and rare recurrence, caused by malignant histological transformation of the tumor.…”

Section: T Shingu Et Almentioning

confidence: 99%

“…5) Pilocytic astrocytoma is a slow-growing tumor, and gross total or subtotal resection without adjuvant therapy results in good outcome in most patients, although several cases of late recurrence have been described, including as long as 36 and 45 years after surgical treatment. 1,4,6,9,14,29) Pilocytic astrocytomas are frequently associated with cysts that occasionally contain xanthochromic or brown fluid suggesting old hemorrhage. 5,30) However, symptomatic hemorrhage related to pilocytic astrocytoma is rare.…”

Section: Introductionmentioning

confidence: 99%

Symptomatic Hemorrhage Associated With Recurrent Pilocytic Astrocytoma With Granulation Tissue-Case Report-

Shingu

Akiyama

Daisu

et al. 2007

Neurol. Med. Chir.(Tokyo)

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A 51-year-old woman had been followed up for 10 years for recurrence of pilocytic astrocytoma 5 years after the initial treatment consisting of subtotal resection, chemotherapy, and radiation therapy. The patient presented with sudden onset of headache and vomiting. Computed tomography and T 2 * -weighted magnetic resonance imaging revealed hemorrhage in the tumor located in the right basal ganglia, thalamus, and hypothalamus. She underwent gross total resection of the lesion. Histological examination confirmed recurrent pilocytic astrocytoma with organizing hematoma and granulation tissue. Although neither symptomatic hemorrhage nor late benign recurrence is common, careful long-term follow up is necessary for patients with pilocytic astrocytoma.

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“…They are seen as welldemarcated and solid masses with cystic components (5). PMA often occurs during early childhood (6,7). In PA; a small number of patients with malignant transformation in recurrent masses after radiotherapy (RT) were reported, and no PMA case with malignant transformation was seen in the literature.…”

Section: Introductionmentioning

confidence: 99%

Pilomyxoid astrocytoma showing malignant transformation in adult male

et al. 2017

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Pilomyxoid astrocytomas are type of tumors rarely seen in the central nervous system as a variant of pilocytic astrocytoma. They are often localized in hypothalamicchiasmatic area and seen in early childhood. They exhibit different histological characteristics and more aggressive behaviors compared to pilocytic astrocytomas. Although cases with malignant transformation were reported in pilocytic astrocytomas, no pilomyxoid astrocytoma patients was reported with malignant transformation. We have presented a pilomyxoid astrocytoma patient, since it is rarely seen in adulthood and shows malignant transformation histopathologically.

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Cerebral pilocytic astrocytoma

Cited by 72 publications

References 10 publications

Outcome of children with centrally reviewed low‐grade gliomas treated with chemotherapy with or without radiotherapy on Children's Cancer Group high‐grade glioma study CCG‐945

Outcome of children with centrally reviewed low‐grade gliomas treated with chemotherapy with or without radiotherapy on Children's Cancer Group high‐grade glioma study CCG‐945

Symptomatic Hemorrhage Associated With Recurrent Pilocytic Astrocytoma With Granulation Tissue-Case Report-

Pilomyxoid astrocytoma showing malignant transformation in adult male

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