Cerebral phaeohyphomycosis caused by<i>Scytalidium dimidiatum</i>: a case report from India

Mani, Reeta Subramaniam; Chickabasaviah, Yasha T; Nagarathna, S; Chandramuki, A; Shivprakash, Mandya Rudramurthy; Vijayan, Joy; Prashantha, D.K.; Vasudevan, Pillai Shibu; Natarajan, A.T.; Kovoor, J.M.E.

doi:10.1080/13693780802172017

Cited by 29 publications

(20 citation statements)

References 19 publications

(15 reference statements)

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“…Cases of mycetoma, subcutaneous and cerebral infections, fungaemia and other deep-seated pathologies have been reported less frequently, mainly affecting patients with predisposing factors such as diabetes mellitus, solid organ transplant, corticosteroid therapy, systemic lupus erythematosus and trauma [2][3][4][5][6][7][8][9]. Optimal therapy has not been developed for diseases caused by N. dimidiatum and several cases of fatal invasive infections have been reported despite antifungal therapy [4,5,8].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antifungal therapy in a neutropenic murine model of Neoscytalidium dimidiatum infection

Ruíz-Cendoya

Madrid

Pastor

et al. 2010

International Journal of Antimicrobial Agents

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Section: Introductionmentioning

confidence: 99%

Evaluation of antifungal therapy in a neutropenic murine model of Neoscytalidium dimidiatum infection

Ruíz-Cendoya

Madrid

Pastor

et al. 2010

International Journal of Antimicrobial Agents

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“…Mortality was Ͼ70%. Since that review in 2004, over 50 cases have been reported, with C. bantiana remaining the most frequently seen isolate (131,4,17,16,22,31,40,70,78,93,121,139,170,189,243,244,268,272,276,328,332,341,363,380,399,420,433,448,450,467,476,545,575,636,657,696,700,721,731,733,754,759). A new species, Fonsecaea monophora, has been reported since that time and appears to have a predilection for causing CNS disease, in contrast to its related species, F. pedrosoi (420,721,733).…”

Section: Phaeohyphomycosismentioning

confidence: 99%

“…This organism is a plant pathogen, and the name should not be used for human isolates. N. dimidiatum primarily produces infections mimicking those caused by dermatophytes on skin and nails (218,459), although there are occasional reports of ocular infections (26) and deep mycoses in immunocompromised individuals (73,476,694,801).…”

Section: Pleosporalesmentioning

confidence: 99%

Melanized Fungi in Human Disease

2010

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SUMMARY Melanized or dematiaceous fungi are associated with a wide variety of infectious syndromes. Many are soil organisms and are generally distributed worldwide, though certain species appear to have restricted geographic ranges. Though they are uncommon causes of disease, melanized fungi have been increasingly recognized as important pathogens, with most reports occurring in the past 20 years. The spectrum of diseases with which they are associated has also broadened and includes allergic disease, superficial and deep local infections, pneumonia, brain abscess, and disseminated infection. For some infections in immunocompetent individuals, such as allergic fungal sinusitis and brain abscess, they are among the most common etiologic fungi. Melanin is a likely virulence factor for these fungi. Diagnosis relies on careful microscopic and pathological examination, as well as clinical assessment of the patient, as these fungi are often considered contaminants. Therapy varies depending upon the clinical syndrome. Local infection may be cured with excision alone, while systemic disease is often refractory to therapy. Triazoles such as voriconazole, posaconazole, and itraconazole have the most consistent in vitro activity. Further studies are needed to better understand the pathogenesis and optimal treatment of these uncommon infections.

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“…The dematiaceus variety is responsible not only for superficial infection as N. dimidiatum var. hyalinum, but also for invasive and deeper infection such as subcutaneous infections [20][21], sinusitis [22][23], endophtalmitis [24], cerebral pheohyphomycosis [25], pneumonia [8,26], and disseminated infections [27][28][29]. As the number of mycoses caused by both varieties is increasing [7,9,30] there is a renewed interest in the study of these fungi.…”

Section: Dimidiatum Was Isolated From Environmental Samples and Patiementioning

confidence: 99%

In vitro susceptibilities of Neoscytalidium spp. sequence types to antifungal agents and antimicrobial photodynamic treatment with phenothiazinium photosensitizers

et al. 2018

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In vitro susceptibilities of Neoscytalidium spp. sequence types to antifungal agents and antimicrobial photodynamic treatment with phenothiazinium photosensitizers http://researchonline.ljmu.ac.uk/7434/ Article LJMU has developed LJMU Research Online for users to access the research output of the University more effectively. Copyright © and Moral Rights for the papers on this site are retained by the individual authors and/or other copyright owners. Users may download and/or print one copy of any article(s) in LJMU Research Online to facilitate their private study or for non-commercial research. You may not engage in further distribution of the material or use it for any profit-making activities or any commercial gain.The version presented here may differ from the published version or from the version of the record. Please see the repository URL above for details on accessing the published version and note that access may require a subscription.

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Cerebral phaeohyphomycosis caused byScytalidium dimidiatum: a case report from India

Cited by 29 publications

References 19 publications

Evaluation of antifungal therapy in a neutropenic murine model of Neoscytalidium dimidiatum infection

Evaluation of antifungal therapy in a neutropenic murine model of Neoscytalidium dimidiatum infection

Melanized Fungi in Human Disease

In vitro susceptibilities of Neoscytalidium spp. sequence types to antifungal agents and antimicrobial photodynamic treatment with phenothiazinium photosensitizers

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