Cerebral Phaeohyphomycosis : A Rare Cause of Brain Abscess

Jung, Na Young; Kim, Ealmaan

doi:10.3340/jkns.2014.56.5.444

Cited by 12 publications

(8 citation statements)

References 26 publications

(79 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Numerous reviews report similar situations where radiological findings confound diagnosis irrespective of the fungal identity. MRS was not useful in differentiating malignant lesions from phaeohyphomycosis (Hauck, McGinnis et al 2008, Santosh, Mahadevan et al 2010, Jung and Kim 2014, Goel, Gupta et al 2019, Magaki, Minasian et al 2019. Fungal etiology was only identified in these cases later from histopathological and microbiological examination.…”

Section: Case Presentationmentioning

confidence: 80%

Invasive cerebral phaeohyphomycosis in a Chinese boy with CARD9 deficiency and showing unique radiological features, managed with surgical excision and antifungal treatment

Lai

Duque

Chung

et al. 2021

International Journal of Infectious Diseases

View full text Add to dashboard Cite

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

Section: Case Presentationmentioning

confidence: 80%

Invasive cerebral phaeohyphomycosis in a Chinese boy with CARD9 deficiency and showing unique radiological features, managed with surgical excision and antifungal treatment

Lai

Duque

Chung

et al. 2021

International Journal of Infectious Diseases

View full text Add to dashboard Cite

show abstract

“…Despite aggressive intervention involving wide excision of infected parenchymal tissue, the mortality rate remains over 70%, particularly in immunosuppressed patients. Furthermore, prognosis is worse in patients with multiple lesions [ 1 , 16 , 19 , 20 , 29 , 30 ]. Among available antifungal treatments for CNS phaeohyphomycosis, 5-flucytosine and voriconazole achieve a high cerebrospinal fluid concentration with their low molecular weight, low to intermediate lipophilicity, and lower protein binding [ 27 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

Gram stain to the rescue: a case report of cerebral phaeohyphomycosis by Cladophialophora bantiana in an immunocompetent 24-year-old

et al. 2022

View full text Add to dashboard Cite

Background Fungal brain abscesses in immunocompetent patients are exceedingly rare. Cladophialophora bantiana is the most common cause of cerebral phaeohyphomycosis, a dematiaceous mold. Radiological presentation can mimic other disease states, with diagnosis through surgical aspiration and growth of melanized fungi in culture. Exposure is often unknown, with delayed presentation and diagnosis. Case presentation We present a case of cerebral phaeohyphomycosis in a 24-year-old with no underlying conditions or risk factors for disease. He developed upper respiratory symptoms, fevers, and headaches over the course of 2 months. On admission, he underwent brain MRI which demonstrated three parietotemporal rim-enhancing lesions. Stereotactic aspiration revealed a dematiaceous mold on staining and the patient was treated with liposomal amphotericin B, 5-flucytosine, and posaconazole prior to culture confirmation. He ultimately required surgical excision of the brain abscesses and prolonged course of antifungal therapy, with clinical improvement. Conclusions Culture remains the gold standard for diagnosis of infection. Distinct microbiologic findings can aid in identification and guide antimicrobial therapy. While little guidance exists on treatment, patients have had favorable outcomes with surgery and combination antifungal therapy. In improving awareness, clinicians may accurately diagnose disease and initiate appropriate therapy in a more timely manner.

show abstract

“…Brain abscess is classic CNS manifestation. [5] However, the patient can also present meningitis, encephalitis, myelitis, or arachnoiditis. [3] Clinical symptoms can vary as memory loss and hemiplegia.…”

Section: Discussionmentioning

confidence: 99%

“…Magnetic resonance spectroscopy brain can help to differentiate. [5] Intraoperative frozen section or crush smear can help in early diagnosis and management of CPHM. [7]…”

Section: Discussionmentioning

confidence: 99%

Cerebral phaeohyphomycosis with onychomycosis: Case report and review of literature

Goel¹,

Gupta²,

Dua³

et al. 2019

Asian J Neurosurg

View full text Add to dashboard Cite

The term phaeohyphomycosis (PHM) means dark-pigmented fungal hyphae. Cerebral PHM (CPHM) with onychomycosis is extremely rare; very few have been reported so far. The authors report a case of CPHM with onychomycosis in a 37-year-old male from a rural background in Haryana, India, with involvement of the left frontal lobe. The mass was resected and biopsy was sent for histopathological examination. He was given antifungal drugs in the postoperative period. The patient responded very well to the treatment, and there were no signs of recurrence at the 6-month follow-up visit. The clinical features, imaging and histopathological investigations, and management of this rare entity are discussed, and the available literature is also reviewed.

show abstract

Cerebral Phaeohyphomycosis : A Rare Cause of Brain Abscess

Cited by 12 publications

References 26 publications

Invasive cerebral phaeohyphomycosis in a Chinese boy with CARD9 deficiency and showing unique radiological features, managed with surgical excision and antifungal treatment

Invasive cerebral phaeohyphomycosis in a Chinese boy with CARD9 deficiency and showing unique radiological features, managed with surgical excision and antifungal treatment

Gram stain to the rescue: a case report of cerebral phaeohyphomycosis by Cladophialophora bantiana in an immunocompetent 24-year-old

Cerebral phaeohyphomycosis with onychomycosis: Case report and review of literature

Contact Info

Product

Resources

About