Cerebral perfusion using ASL in patients with COVID-19 and neurological manifestations: A retrospective multicenter observational study

Ardellier, François-Daniel; Baloglu, Seyyid; Sokolska, Magdalena; Noblet, Vincent; Lersy, François; Collange, Olivier; Ferré, Jean-Christophe; Maamar, Adel; Carsin-Nicol, B.; Helms, Julie; Schenck, Maleka; Khalil, Antoine; Gaudemer, Augustin; Caillard, Sophie; Pottecher, Julien; Lefèbvre, Nicolas; Zorn, Pierre-Emmanuel; Matthieu, Muriel; Brisset, Jean Christophe; Boulay, Clotilde; Mutschler, Véronique; Hansmann, Yves; Mertès, Paul-Michel; Schneider, Francis; Fafi‐Kremer, Samira; Ohana, Mickaël; Meziani, Ferhat; Meyer, Nicolás; Yousry, Tarek; Anheim, Mathieu; Cotton, François; Jäger, Hans Rolf; Kremer, Stéphane; Bonneville, Fabrice; Adam, Gilles; Martin‐Blondel, Guillaume; Pariente, Jérémie; Geeraerts, Thomas; Oesterlé, Hélène; Bolognini, Federico; Messié, Julien; Hmeydia, Ghazi; Benzakoun, Joseph; Oppenheim, Catherine; Constans, Jean-Marc; Metanbou, Serge; Heintz, Adrien; Bapst, Blanche; Megdiche, Imen; Jager, Lavinia; Nesser, Patrick; Talla, Yannick; Tourdias, Thomas; Coutureau, Juliette; Hemmert, Céline; Feuerstein, Philippe; Sebag, Nathan; Carré, Sophie; Alleg, Manel; Lecocq, Claire; Schmitt, Emmanuel; Anxionnat, René; Zhu, François; Forestier, Géraud; Rouchaud, Aymeric; Comby, Pierre-Olivier; Ricolfi, F.; Thouant, Pierre; Grand, Sylvie; Krainik, Alexandre; Beaurepaire, Isaure de; Bornet, Grégoire; Lacalm, Audrey; Miailhes, Patrick; Pique, Julie; Billen, Claire; Fabré, Xavier; Claise, Béatrice; Mirafzal, Sonia; Calvet, Laure; Desal, Hubert; Berge, Jérôme; Boulouis, Grégoire; Kazémi, Apolline; Pyatigorskaya, Nadya; Saleme, Suzana; Edjlali, Myriam; Kerleroux, Basile; Brisset, Jean-Christophe; Chenaf, Samir

doi:10.1016/j.neurad.2023.01.005

Cited by 8 publications

(12 citation statements)

References 39 publications

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“…Hypoperfusion is typically more severe in patients with severe COVID-19 compared to mild COVID-19 ( Qin et al, 2021 ). Some studies have additionally observed hyperperfusion in a minority of their COVID-19 patient sample ( Ardellier et al, 2023 , Henry-Feugeas et al, 2020 , Lambrecq et al, 2021 , Lersy et al, 2022 , Chammas et al, 2021 ). Two studies observed neither hypoperfusion nor hyperperfusion within COVID-19 patients ( Klironomos et al, 2020 ) or between COVID-19 patients and healthy controls ( Hosp et al, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

“…Most studies assessing perfusion in COVID-19 patients report lower global tissue perfusion, i.e., hypoperfusion ( Kim et al, 2023 , Ajčević et al, 2023 , Ardellier et al, 2023 , Sen et al, 2023 , Díez-Cirarda et al, 2023 , Chougar et al, 2020 , Henry-Feugeas et al, 2020 , Lambrecq et al, 2021 , Lersy et al, 2022 , Qin et al, 2021 , Tian et al, 2022 ). Hypoperfusion is typically more severe in patients with severe COVID-19 compared to mild COVID-19 ( Qin et al, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

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On the merits and potential of advanced neuroimaging techniques in COVID-19: A scoping review

van der Knaap,

Ariës,

van der Horst

et al. 2024

NeuroImage: Clinical

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

On the merits and potential of advanced neuroimaging techniques in COVID-19: A scoping review

van der Knaap,

Ariës,

van der Horst

et al. 2024

NeuroImage: Clinical

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“…There are numerous well‐documented impacts of COVID‐19 on the brain in the literature (Ardellier et al, 2023 ; Esposito et al, 2022 ; Kim et al, 2022 ; Kremer et al, 2020 ; Lu et al, 2020 ; Qin et al, 2021 ; Voudris et al, 2001 ). It is clear that COVID can not only enter the brain (Reiken et al, 2022 ), but can also have numerous metabolic, immune, and hematologic effects (Shaikh et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Feasibility of diffusion‐tensor and correlated diffusion imaging for studying white‐matter microstructural abnormalities: Application in COVID‐19

Teller

Chad

Wong

et al. 2023

Human Brain Mapping

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There has been growing attention on the effect of COVID‐19 on white‐matter microstructure, especially among those that self‐isolated after being infected. There is also immense scientific interest and potential clinical utility to evaluate the sensitivity of single‐shell diffusion magnetic resonance imaging (MRI) methods for detecting such effects. In this work, the performances of three single‐shell‐compatible diffusion MRI modeling methods are compared for detecting the effect of COVID‐19, including diffusion‐tensor imaging, diffusion‐tensor decomposition of orthogonal moments and correlated diffusion imaging. Imaging was performed on self‐isolated patients at the study initiation and 3‐month follow‐up, along with age‐ and sex‐matched controls. We demonstrate through simulations and experimental data that correlated diffusion imaging is associated with far greater sensitivity, being the only one of the three single‐shell methods to demonstrate COVID‐19‐related brain effects. Results suggest less restricted diffusion in the frontal lobe in COVID‐19 patients, but also more restricted diffusion in the cerebellar white matter, in agreement with several existing studies highlighting the vulnerability of the cerebellum to COVID‐19 infection. These results, taken together with the simulation results, suggest that a significant proportion of COVID‐19 related white‐matter microstructural pathology manifests as a change in tissue diffusivity. Interestingly, different b‐values also confer different sensitivities to the effects. No significant difference was observed in patients at the 3‐month follow‐up, likely due to the limited size of the follow‐up cohort. To summarize, correlated diffusion imaging is shown to be a viable single‐shell diffusion analysis approach that allows us to uncover opposing patterns of diffusion changes in the frontal and cerebellar regions of COVID‐19 patients, suggesting the two regions react differently to viral infection.

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“…(2) in the later recovery phase, those with severe initial COVID-19 infection show global hypoperfusion that correlates with poor recovery outcome 7 ; and (3) those with milder initial COVID-19 infection show white matter (WM) tract changes, possibly resulting from WM ischemia-hypoxia or immune-mediated inflammatory demyelination. 8 The purpose of the current study was to investigate global and regional WM and gray matter (GM) hypoperfusion in a group of patients with milder COVID-19 infection.…”

Section: Introductionmentioning

confidence: 99%

“…An increase in CBF has been demonstrated in most cases, namely, herpes simplex virus and tick‐borne encephalitis, while a reduction in CBF occurs with human immunodeficiency virus infection 5 . With COVID‐19 infection, at least three patterns of cerebral perfusion abnormalities have been reported: (1) in the early encephalitis phase, N ‐isopropyl‐[123I]p‐iodoamphetamine (123I‐IMP) SPECT studies show cerebral hyperperfusion is possibly related to inflammation 6 ; (2) in the later recovery phase, those with severe initial COVID‐19 infection show global hypoperfusion that correlates with poor recovery outcome 7 ; and (3) those with milder initial COVID‐19 infection show white matter (WM) tract changes, possibly resulting from WM ischemia‐hypoxia or immune‐mediated inflammatory demyelination 8 . The purpose of the current study was to investigate global and regional WM and gray matter (GM) hypoperfusion in a group of patients with milder COVID‐19 infection.…”

Section: Introductionmentioning

confidence: 99%

Cerebral blood flow in patients recovered from mild COVID‐19

Sen

Newman‐Norlund

Riccardi

et al. 2023

Journal of Neuroimaging

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Background and PurposeCerebral hypoperfusion has been described in both severe and mild forms of symptomatic Coronavirus Disease 2019 (COVID‐19) infection. The purpose of this study was to investigate global and regional cerebral blood flow (CBF) in asymptomatic COVID‐19 patients.MethodsCases with mild COVID‐19 infection and age‐, sex‐, and race‐matched healthy controls were drawn from the Aging Brain Consortium at The University of South Carolina data repository. Demographics, risk factors, and data from the Montreal Cognitive Assessment were collected. Mean CBF values for gray matter (GM), white matter (WM), and the whole brain were calculated by averaging CBF values of standard space‐normalized CBF image values falling within GM and WM masks. Whole brain region of interest‐based analyses were used to create standardized CBF maps and explore differences between groups.ResultsTwenty‐eight cases with prior mild COVID‐19 infection were compared with 28 controls. Whole‐brain CBF (46.7 ± 5.6 vs. 49.3 ± 3.7, p = .05) and WM CBF (29.3 ± 2.6 vs. 31.0 ± 1.6, p = .03) were noted to be significantly lower in COVID‐19 cases as compared to controls. Predictive models based on these data predicted COVID‐19 group membership with a high degree of accuracy (85.2%, p < .001), suggesting CBF patterns are an imaging marker of mild COVID‐19 infection.ConclusionIn this study, lower WM CBF, as well as widespread regional CBF changes identified using quantitative MRI, was found in mild COVID‐19 patients. Further studies are needed to determine the reliability of this newly identified COVID‐19 brain imaging marker and determine what drives these CBF changes.

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Cerebral perfusion using ASL in patients with COVID-19 and neurological manifestations: A retrospective multicenter observational study

Cited by 8 publications

References 39 publications

On the merits and potential of advanced neuroimaging techniques in COVID-19: A scoping review

On the merits and potential of advanced neuroimaging techniques in COVID-19: A scoping review

Feasibility of diffusion‐tensor and correlated diffusion imaging for studying white‐matter microstructural abnormalities: Application in COVID‐19

Cerebral blood flow in patients recovered from mild COVID‐19

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