Cerebral Perfusion Changes in Schizophrenic Patients Using Tc-99m Hexamethylpropylene Amineoxime (HMPAO)

Abdel‐Dayem, Hussein M.; El-Hilu, Saleh M.; Sehweil, A.; Higazi, Ezzat; Jahan, Sharmila; Salhat, M; Al-Mohannadi, S.

doi:10.1097/00003072-199007000-00003

Cited by 7 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The abnormalities of hand posture that were observed in the childhood films of our preschizophrenia subjects are similar to those that have been found to occur at an elevated rate throughout development in children with known or suspected CNS damage (Knobloch and Pasamanick 1974;Saint-Anne Dargassies 1982;Stengel et al 1984). Abnormalities of hand posture are viewed by some as a mild manifestation of athetotic movement (Knobloch and Pasamanick 1974;Adams and Salem-Adams 1992). This conceptualization is consistent with our findings.…”

Section: Neuromotor Precursors Of Schizophreniasupporting

confidence: 90%

“…Evidence of basal ganglia dysfunction in schizophrenia has also been detected with single photon emission computed tomography (SPECT). A recent SPECT study of 20 medicated schizophrenia patients found that the most common abnormalities were lesions associated with increased perfusion in the basal ganglia (Abdel-Dayem et al 1990). Lesions associated with decreased perfusion were less frequent and occurred in a variety of areas, including the parietal, frontal, temporal, and occipital lobes.…”

Section: Structural and Functional Abnormalities Of The Brain In Schi...mentioning

confidence: 99%

See 1 more Smart Citation

Developmentally Moderated Expressions of the Neuropathology Underlying Schizophrenia

Walker

1994

Schizophrenia Bulletin

185

123

View full text Add to dashboard Cite

A gradually accumulating body of literature suggests that behavioral dysfunction precedes the onset of the schizophrenic syndrome by many years. Thus, a comprehensive neurodevelopmental model of schizophrenia must encompass these early manifestations of dysfunction as well as the postmorbid period. This article draws on previous research findings as well as recently proposed neurodevelopmental models to offer some further hypotheses about the neurodevelopmental process underlying the changing life-course manifestations of the diathesis for schizophrenia. It is proposed that normal maturational events in the central nervous system moderate the behavioral expression of a congenital neuropathology that affects subcortical regions of the brain that are part of multiple neural circuits. Specifically, it is suggested that the diathesis for schizophrenia involves a functional excess of dopamine activity in the basal ganglia that serves to disrupt these circuits. Findings from empirical research suggest a modal developmental trajectory for schizophrenia in which neuromotor dysfunction is most pronounced in early childhood and late in life, whereas florid psychotic symptomatology is most pronounced in late adolescence and early adulthood. The literature on normal central nervous system development suggests that the feedback circuit linking motor cortex with subcortical structures is maximally metabolically activated, relative to other circuits, early and late in the life course. Thus, subcortical dopamine excess may be predominantly expressed in motoric symptoms during these periods. In contrast, late adolescence and early adulthood are marked by low motor cortex metabolic activity relative to other cortical regions, in particular limbic and frontal regions. In addition, hormonal changes appear to result in a maximal activation of the dopamine system during this developmental period. Thus, it is hypothesized that during this period the neural circuitry abnormality will be primarily behaviorally expressed in psychotic symptoms. Some implications of the model for the study of movement abnormalities and psychotic symptoms are discussed.

show abstract

Section: Neuromotor Precursors Of Schizophreniasupporting

confidence: 90%

Section: Structural and Functional Abnormalities Of The Brain In Schi...mentioning

confidence: 99%

Developmentally Moderated Expressions of the Neuropathology Underlying Schizophrenia

Walker

1994

Schizophrenia Bulletin

185

123

View full text Add to dashboard Cite

show abstract

“…Most studies have used structural MRI (Henn & Braus, 1999), whereas nearly all studies of cerebral perfusion in major psychosis have been made using Tc 99 m HMPAO SPECT (Bajc et al. 1989; Abdel‐Dayem et al. 1990; Sachdev et al.…”

Section: Discussionmentioning

confidence: 99%

Three‐dimensional MRI perfusion maps: a step beyond volumetric analysis in mental disorders

et al. 2006

View full text Add to dashboard Cite

A new type of magnetic resonance imaging analysis, based on fusion of three-dimensional reconstructions of timeto-peak parametric maps and high-resolution T1-weighted images, is proposed in order to evaluate the perfusion of selected volumes of interest. Because in recent years a wealth of data have suggested the crucial involvement of vascular alterations in mental diseases, we tested our new method on a restricted sample of schizophrenic patients and matched healthy controls. The perfusion of the whole brain was compared with that of the caudate nucleus by means of intrasubject analysis. As expected, owing to the encephalic vascular pattern, a significantly lower time-to-peak was observed in the caudate nucleus than in the whole brain in all healthy controls, indicating that the suggested method has enough sensitivity to detect subtle perfusion changes even in small volumes of interest. Interestingly, a less uniform pattern was observed in the schizophrenic patients. The latter finding needs to be replicated in an adequate number of subjects. In summary, the three-dimensional analysis method we propose has been shown to be a feasible tool for revealing subtle vascular changes both in normal subjects and in pathological conditions.

show abstract

Modal Developmental Aspects of Schizophrenia Across the Life Span

Walker¹,

Davis²,

Weinstein³

et al. 1995

The Behavioral High-Risk Paradigm in Psychopathology

View full text Add to dashboard Cite

Cerebral Perfusion Changes in Schizophrenic Patients Using Tc-99m Hexamethylpropylene Amineoxime (HMPAO)

Cited by 7 publications

References 0 publications

Developmentally Moderated Expressions of the Neuropathology Underlying Schizophrenia

Developmentally Moderated Expressions of the Neuropathology Underlying Schizophrenia

Three‐dimensional MRI perfusion maps: a step beyond volumetric analysis in mental disorders

Modal Developmental Aspects of Schizophrenia Across the Life Span

Contact Info

Product

Resources

About