Cerebral palsy in preterm infants

Demesi-Drljan, Cila; Mikov, Aleksandra; Filipović, Karmela; Tomasevic-Todorovic, Snezana; Knežević, Aleksandar; Krasnik, Rastislava

doi:10.2298/vsp140321019d

Cited by 10 publications

(8 citation statements)

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“…An estimated 14.8 million premature babies were born across the globe annually, with the death rate as high as 17.8% (Liu et al, 2016). Survived premature babies are at higher risk than term babies of various health problems, among which the worst one is cerebral palsy (Demesi Drljan et al, 2016;Natarajan and Shankaran, 2016). Although PTB has become a terrible threat to global health, its specific molecular mechanism remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Identification and Characterization of Circular RNA as a Novel Regulator and Biomarker in Preterm Birth

Ran

Yin

Huang

et al. 2020

Front. Bioeng. Biotechnol.

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Preterm birth (PTB), as the leading cause of neonatal death, is a severe threat to maternal–fetal health. The diagnosis and treatment of PTB are difficult as its underlying mechanism still unknown. Circular RNA (circRNA) is an emerging molecule that plays an essential role in the pathological processes of various diseases. However, it is still unclear whether circRNAs are abnormal or involves in the PTB pathology. In this study, we analyzed RNA-seq data of peripheral blood from preterm and term pregnant women and verified with microarray data. There were 211 circRNA expression disorders in PTB, of which 68 increased and 143 decreased. Bioinformatics analysis revealed that the top 20 circRNAs competitively bind 68 miRNAs, thereby regulating 622 mRNAs mainly related to immunity, inflammation, and nerve activity, which may ultimately contribute to the occurrence of PTB. Moreover, 6 regulatory pairs, including hsa-MORC3_0001–hsa-miR-1248–CHRM2 were the core parts of this mechanism network, which might be therapeutic targets for PTB. Besides, ROC analysis indicated that hsa-ANKFY1_0025, hsa-FAM13B_0019, and hsa-NUSAP1_0010 (AUC = 0.7138, 0.9589, 1.000) have an excellent discrimination ability for PTB. Taken together, we explored for the first time the circRNA expression profile of PTB, and preliminarily analyzed its regulatory mechanism and predictive value for PTB, thus bringing new light to the diagnosis and treatment of PTB.

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Section: Introductionmentioning

confidence: 99%

Identification and Characterization of Circular RNA as a Novel Regulator and Biomarker in Preterm Birth

Ran

Yin

Huang

et al. 2020

Front. Bioeng. Biotechnol.

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“…Out of 145 children with CP for whom gestational age was recorded, 54.4% were born prematurely, whereby 30.3% were born after 32−36 weeks of gestation, 17.2% were delivered after 28−31 weeks of gestation, and 6.9% were born before 28th gestational week. As shown in Table 3-reproduced from our earlier study (11)-the difference in distribution is statistically highly significant (χ 2 = 48.572, p < 0.001).…”

Section: Resultsmentioning

confidence: 53%

“…The main study (involving 206 children) and all its components were approved by the Ethics Committee of the Institute. The data collection methods used are already described in our previous publications (11), and focused on participants' gestational age at birth, medical history, and CP clinical characteristics. For each child, SCPE (Surveillance of Cerebral Palsy in Europe) and European commission guidelines (https://eu-rd-platform.jrc.ec.europa.eu/scpe/datacollection/cp-subtypes_en) were used to determine clinical CP type.…”

Section: Methodsmentioning

confidence: 99%

“…Once the data was entered into our database as previously described (11), descriptive and inferential statistics were calculated and findings were reported as percentages and frequencies. Observed frequencies in the attributive characteristics were compared to the expected values via χ 2 test, whereas Spearman' ρ was calculated to assess pairwise correlations between characteristics.…”

Section: Methodsmentioning

confidence: 99%

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Risk factors for cerebral palsy

et al. 2023

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Background / Aim. Cerebral palsy (CP) etiology is multifactorial and heterogeneous, manifesting as damage to the developing brain. The associated risk factors can arise in the prenatal, perinatal, or postnatal period. This work is a part of a larger classical clinicalepidemiological qualitative study and some of its components were already described in our previous publications. The objective of this investigation was to determine the risk factors for CP and to examine the associations between CP type, gestational age, and perinatal risk factors. Methods. The study sample comprised of 206 children with CP. Pertinent data were collected from medical records, and included participants? gestational age at birth, medical history, and CP clinical characteristics. Risk factors were divided according to the timing of brain injury into prenatal, perinatal, and neonatal. Results. Hormonally maintained pregnancy (55.3%), twin pregnancy (28.9%), vaginal bleeding after the 20th week of gestation (21.1%), threatened abortion in the first half of pregnancy (13.2%), and maternal infection (10.5%) were identified as the main prenatal risk factors for CP. Prematurity (54.5%) was the leading perinatal risk factor, followed by low birthweight (50.8%), low Apgar score (41.7%), assisted delivery (41.4%), and breech presentation (13.5%). Respiratory distress syndrome (16%), need for treatment in the NICU (22.3%), assisted ventilation (18.4%), hypoxic ischemic encephalopathy ? HIE (11.2%), and neonatal convulsions (5.8%) were identified as the leading neonatal risk factors for CP. The total number of perinatal factors present differed significantly in relation to gestational age (p < 0.001) and CP type (p = 0.006). Perinatal risk factors were most prevalent in preterm infants and children affected by the CP of spastic bilateral type. Statistically significant difference was noted in the distribution of CP types depending on the gestational age (p < 0.001). In particular, spastic bilateral CP type was most prevalent in the group of preterm-born children. Conclusion. CP is characterized by heterogeneous risk factors and is a result of interaction among multiple risk factors.

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“…According to the current definition, developed by an international team of experts, CP is a group of permanent, but not unchanging, disorders of movement and/or posture and motor function, which are the result of non-progressive disorders, lesions or abnormalities of the developing brain [6]. The CP is one of the leading causes of neurological impairment in childhood [7]. The incidence of CP is 2 -3 per 1000 term, live births, while the incidence in preterm infants it ranges from 40 to 200 per 1000 live births [3,8,9].…”

Section: Cerebral Palsymentioning

confidence: 99%

Eating and swallowing disorders in children with cerebral palsy

Vuković

Todorovic²

2021

Med pregl

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Introduction. Cerebral palsy is characterized by abnormalities of muscle tone, movement and motor abilities caused by disorders in brain development. Many children with cerebral palsy have severe swallowing problems. Cerebral Palsy. Cerebral palsy is a neurodevelopmental disorder characterized by abnormalities in brain development. Swallowing is a process by which a bolus that is formed within the oral cavity is transported through the pharynx into the esophagus and stomach. It has four phases: preparatory oral, oral, pharyngeal and esophageal. Swallowing disorders in children with cerebral palsy. Swallowing disorders vary depending on the type of cerebral palsy. Children with spastic paralysis have a more pronounced disorder of the voluntary phases of swallowing, while children with athetoid paralysis are expected to have a disorder at the oral-motor level. Neurological lesions may affect the muscle function of the jaw, cheeks, lips, tongue, palate and pharynx, which is manifested by difficulties in controlling saliva and swallowing. Diagnosis and treatment of dysphagia in cerebral palsy. Diagnosis and treatment of dysphagia is best accomplished by a team of experts including a pediatrician, neurologist, otorhinolaryngologist, gastroenterologist, radiologist, dental specialist, speech therapist, nutritionist, and a specialist in physical medicine and rehabilitation. Conclusion. Dysphagia is a common comorbidity in children with cerebral palsy. Although swallowing disorders often correlate with the type of cerebral palsy, the most prevalent signs of dysphagia include: coughing, prolonged feeding time, laryngotracheal penetration and aspiration, suffocation, which leads to dehydration, malnutrition, but also to the need for alternative feeding methods. It is important to emphasize the importance of early treatment by a team of experts, with a speech therapist as a team leader.

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Cerebral palsy in preterm infants

Abstract: The application of antenatal and postnatal protection of preterm children should be a significant component of the CP prevention strategy.

Cited by 10 publications

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Identification and Characterization of Circular RNA as a Novel Regulator and Biomarker in Preterm Birth

Identification and Characterization of Circular RNA as a Novel Regulator and Biomarker in Preterm Birth

Risk factors for cerebral palsy

Eating and swallowing disorders in children with cerebral palsy

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