Cerebral Palsy in Maiduguri, Nigeria: A Case for Meningitis Prevention

Peters, Grace O; Ojo, John

doi:10.1093/tropej/fms027

Cited by 2 publications

(4 citation statements)

References 5 publications

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“…Multiple studies found that perinatal risk factors were most prominent, with approximately half to two‐thirds of several cohorts reporting perinatal events (Table S3). In particular, neonatal HIE, 11,32,37–42,46,53,54,59–63 kernicterus, 11,32,33,37–42,44,46,53,54,60–63 and infections 11,22,32,37–41,46,52,53,60–65 were important risk factors for CP in Africa. Cohort studies found that the proportion of children with CP at follow‐up was 15.5% among those with HIE in South Africa ( p < 0.001), 59 16.5% among those with kernicterus in Nigeria, 44 and 7.7% among those with enteroviral meningitis in Tunisia 64 …”

Section: Resultsmentioning

confidence: 99%

“…Although possible aetiologies for CP in African children ranged from antenatal through peripartum to postnatal factors, 11,19,22,32,33,37–63 the proportion of children with no identifiable risk factors was as high as 26% even in hospital‐based populations (Table S3). 11 …”

Section: Resultsmentioning

confidence: 99%

“…CP makes a large contribution to the burden of disease from neurological conditions seen at hospital clinics 37,39,40,60,65,69,70,77,102 and emergency centres 103 in Africa (Table S1). The reported proportion of children with CP between these clinics ranged from 4% 102 to 55.3% of attending children; 70 13.3% of children with an existing diagnosis presenting to the emergency department of an Egyptian tertiary hospital over a 1‐year period had CP 103 …”

Section: Resultsmentioning

confidence: 99%

“…43 A South African case-control study found that physical activity levels, as measured by step count, were comparable between adolescents with CP classified in GMFCS levels I to III and typically developing adolescents. 101 Health care use, school attendance, and barriers to accessing care CP makes a large contribution to the burden of disease from neurological conditions seen at hospital clinics 37,39,40,60,65,69,70,77,102 and emergency centres 103 in Africa (Table S1). The reported proportion of children with CP between these clinics ranged from 4% 102 to 55.3% of attending children; 70 13.3% of children with an existing diagnosis presenting to the emergency department of an Egyptian tertiary hospital over a 1-year period had CP.…”

Section: Functional Outcomesmentioning

confidence: 99%

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Cerebral palsy in African paediatric populations: A scoping review

Murugasen,

Springer,

Olusanya

et al. 2024

Develop Med Child Neuro

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AimTo review the epidemiology and outcomes of African children with cerebral palsy (CP) over a 21‐year period.MethodThe PubMed, Scopus, and Web of Science online databases were searched for original research on African children with CP aged 18 years and younger published from 2000 to 2021.ResultsA total of 1811 articles underwent review against explicit criteria; 93 articles were selected for inclusion in the scoping review. The reported prevalence of CP ranged from 0.8 to 10 per 1000 children. Almost half had perinatal risk factors, but up to 26% had no identifiable risk factor. At least one‐third of children with CP had one or more comorbidities, most commonly epilepsy, intellectual disability, and malnutrition. African children with CP demonstrated excess premature mortality approximately 25 times that of the general population, predominantly from infections. Hospital‐based and younger populations had larger proportions of children with severe impairments. African children with CP had inadequate access to care and education, yet showed functional improvements compared to controls for all evaluated interventions.InterpretationThe prevalence of CP in Africa remains uncertain. African children with CP have different risk profiles, greater premature mortality, and more severe functional impairments and comorbidities compared to the Global North. Several barriers prevent access to optimal care. Larger African studies on validated and effective interventions are needed.

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