Cerebral oxygenation and blood flow in normal term infants at rest measured by a hybrid near-infrared device (BabyLux)

Andresen, Björn F.; Carli, Agnese De; Fumagalli, Monica; Giovannella, Martina; Durdurán, Turgut; Weigel, Udo M.; Contini, Davide; Spinelli, Lorenzo; Torricelli, Alessandro; Greisen, Gorm

doi:10.1038/s41390-019-0474-9

Cited by 20 publications

(20 citation statements)

References 35 publications

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“…Previously reported precision as within infant variation for

was between 1.7% and 8.2%. 18 , 22 , 28 , 29 The high variability of reported precision values has to be assigned to the fact that different devices were used, and different source–detector distances and measurement protocols were used. Szczapa et al.…”

Section: Discussionmentioning

confidence: 99%

“… 17 For a different device (Babylux), it has been shown recently that t-NIRS technology achieved an improved intrasubject variability for cerebral oxygenation measurements when compared with spatially resolved spectroscopy. 18 The primary aim of this study was to estimate precision of cerebral

measurements for a new time-resolved NIRS device, the tNIRS-1 (Hamamatsu Photonics K.K., Hamamatsu, Japan). Furthermore, the secondary aim was to investigate the precision of

, heart rate (HR), t-HB,

, and t-HHb measures.…”

Section: Introductionmentioning

confidence: 99%

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Precision of time-resolved near-infrared spectroscopy-based measurements of cerebral oxygenation in preterm infants

et al. 2021

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“…Previously reported precision as within infant variation for

Section: Discussionmentioning

confidence: 99%

measurements for a new time-resolved NIRS device, the tNIRS-1 (Hamamatsu Photonics K.K., Hamamatsu, Japan). Furthermore, the secondary aim was to investigate the precision of

, heart rate (HR), t-HB,

, and t-HHb measures.…”

Section: Introductionmentioning

confidence: 99%

Precision of time-resolved near-infrared spectroscopy-based measurements of cerebral oxygenation in preterm infants

et al. 2021

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“…7, is capable of measuring the absolute concentrations of deoxygenated-hemoglobin (deoxy [HbϩMb]), oxygenated-hemoglobin (oxy [HbϩMb]), total hemoglobin (total[HbϩMb]), and hemoglobin oxygen saturation (StO 2 ; %) as well as BF i and MRO 2i . The same quantities can be measured in newborns by a recent commercially available system that combines time-domain NIRS and DCS (1,18). Regarding the application of the hybrid FDNIRS-DCS system for human skeletal muscle studies, so far, the instrument has been utilized only to measure relative BF i changes in flexor digitorum superficialis muscle BF during the 10-s end-stage resting periods of exercise of varying power (24).…”

Section: Introductionmentioning

confidence: 99%

Diffuse correlation spectroscopy and frequency-domain near-infrared spectroscopy for measuring microvascular blood flow in dynamically exercising human muscles

Quaresima

Anderson

et al. 2019

Journal of Applied Physiology

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In the last 20 yr, near-infrared diffuse correlation spectroscopy (DCS) has been developed for providing a noninvasive estimate of microvascular blood flow (BF) as a BF index (BFi) in the human skin, muscle, breast, brain, and other tissue types. In this study, we proposed a new motion correction algorithm for DCS-derived BFi able to remove motion artifacts during cycling exercise. We tested this algorithm on DCS data collected during cycling exercise and demonstrated that DCS can be used to quantify muscle BFi during dynamic high-intensity exercise. In addition, we measured tissue regional oxygen metabolic rate (MRO2i) by combining frequency-domain multidistance near-infrared spectroscopy (FDNIRS) oximetry with DCS flow measures. Recreationally active subjects ( n = 12; 31 ± 8 yr, 183 ± 4 cm, 79 ± 10 kg) pedaled at 80–100 revolutions/min until volitional fatigue with a work rate increase of 30 W every 4 min. Exercise intensity was normalized in each subject to the cycling power peak (Wpeak). Both rectus femoris BFi and MRO2i increased from 15% up to 75% Wpeak and then plateaued to the end of the exercise. During the recovery at 30 W cycling power, BFi remained almost constant, whereas MRO2i started to decrease. The BFi/MRO2i plateau was associated with the rising of the lactate concentration, indicating the progressive involvement of the anaerobic metabolism. These findings further highlight the utility of DCS and FDNIRS oximetry as effective, reproducible, and noninvasive techniques to assess muscle BFi and MRO2i in real time during a dynamic exercise such as cycling. NEW & NOTEWORTHY To the best of our knowledge, this study is the first to demonstrate that diffuse correlation spectroscopy in combination with frequency-domain near-infrared spectroscopy can monitor human quadriceps microvascular blood flow and oxygen metabolism with high temporal resolution during a cycling exercise. The optically measured parameters confirm the expected relationship between blood flow, muscle oxidative metabolism, and lactate production during exercise.

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“…The CV for the absorption coefficient is lower than 1.5% for both wavelengths, whereas a maximum CV of 3% has been retrieved for the estimation of reduced scattering coefficient. To assess the variability of measurement results compared to the repositioning of the probe on the sample, a protocol, already used in similar studies [26] has been followed. The protocol consisted in 10 consecutive measurements, with 10 s measuring time each, in constant experimental condition, over a total period of 5 minutes.…”

Section: Reproducibility and Probe Repositioningmentioning

confidence: 99%

Wearable and wireless time-domain near-infrared spectroscopy system for brain and muscle hemodynamic monitoring

Lacerenza¹,

Buttafava²,

Renna³

et al. 2020

Biomed. Opt. Express

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We present a wearable time-domain near infrared spectroscopy (TD-NIRS) system (two wavelengths, one detection channel), which fits in a backpack and performs real-time hemodynamic measurements on the brain and muscle tissues of freely moving subjects. It can provide concentration values of oxygenated hemoglobin (O 2 Hb), deoxygenated hemoglobin (HHb), total hemoglobin (tHb = O 2 Hb + HHb) and tissue oxygen saturation (StO 2). The system is battery-operated and can be wirelessly controlled. By following established characterization protocols for performance assessment of diffuse optics instruments, we achieved results comparable with state-of-the-art research-grade TD-NIRS systems. We also performed in-vivo measurements such as finger tapping (motor cortex monitoring), breath holding (prefrontal cortex monitoring and forearm muscle monitoring), and outdoor bike riding (vastus lateralis muscle monitoring), in order to test the system capabilities in evaluating both muscle and brain hemodynamics.

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Cerebral oxygenation and blood flow in normal term infants at rest measured by a hybrid near-infrared device (BabyLux)

Abstract: Cerebral oxygenation and blood flow in normal term infants at rest measured by a hybrid near-infrared device (BabyLux), Pediatric Research

Cited by 20 publications

References 35 publications

Precision of time-resolved near-infrared spectroscopy-based measurements of cerebral oxygenation in preterm infants

Precision of time-resolved near-infrared spectroscopy-based measurements of cerebral oxygenation in preterm infants

Diffuse correlation spectroscopy and frequency-domain near-infrared spectroscopy for measuring microvascular blood flow in dynamically exercising human muscles

Wearable and wireless time-domain near-infrared spectroscopy system for brain and muscle hemodynamic monitoring

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