Cerebral Mycotic Aneurysm Complicating Stomatococcus mucilaginosus Infective Endocarditis

Pérez-Vega, César; Narváez, Javier; Calvo, Gemma; Castro-Bohorquez, Francisco J; Falgueras, María Teresa; Vilaseca-Momplet, Jaime

doi:10.1080/0036554021000026956

Cited by 10 publications

(10 citation statements)

References 30 publications

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“…Therefore, these early studies have suggested that Rothia spp. are infective opportunistic pathogens, especially in immunocompromised patients . Because Rothia infections pose a much more serious health issue than previously thought, the development of simple and effective approaches to minimize and/or prevent their infectivity is crucial.…”

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confidence: 99%

Anti‐biofilm and antibacterial activities of zinc oxide nanoparticles against the oral opportunistic pathogens Rothia dentocariosa and Rothia mucilaginosa

Khan

Ahamed

Musarrat

et al. 2014

European J Oral Sciences

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Species of the genus Rothia that inhabit the oral cavity have recently been implicated in a number of diseases. To minimize their role in oral infections, it is imperative to reduce and/or control the growth and biofilm formation activity of Rothia spp. In this study, two bacterial isolates, Ora-7 and Ora-16, were obtained from the oral cavity of a healthy male subject and identified as Rothia dentocariosa and Rothia mucilaginosa, respectively, using a polyphasic taxonomic approach. Antimicrobial and anti-biofilm formation activities of zinc oxide nanoparticles (ZnO-NPs), of average size 35 nm, were assessed in in vitro assays using Crystal Violet and live and dead staining techniques. The ZnO-NPs exhibited an IC50 value of 53 and 76 μg ml(-1) against R. dentocariosa and R. mucilaginosa, respectively. Biofilm-formation assays, performed on the surfaces of polystyrene plates, artificial teeth, and dental prostheses, revealed the efficacy of ZnO-NPs as a potential antibacterial agent for controlling the growth of Rothia isolates in both planktonic form and biofilm.

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confidence: 99%

Anti‐biofilm and antibacterial activities of zinc oxide nanoparticles against the oral opportunistic pathogens Rothia dentocariosa and Rothia mucilaginosa

Khan

Ahamed

Musarrat

et al. 2014

European J Oral Sciences

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“…mucilaginosa is a normal inhabitant of the human oral cavity and respiratory tract (2). It is an infrequent pathogen, mostly affecting immunocompromised hosts, such as patients with cancer and severe neutropenia, human immunodeficiency virus infection, alcoholism, diabetes mellitus, and chronic liver disease (3)(4)(5). Recently, infections in immunocompetent hosts have been reported with increasing frequency.…”

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confidence: 99%

Rothia mucilaginosa Prosthetic Device Infections: a Case of Prosthetic Valve Endocarditis

et al. 2013

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bRothia mucilaginosa is increasingly recognized as an emerging opportunistic pathogen associated with prosthetic device infections. Infective endocarditis is one of the most common clinical presentations. We report a case of R. mucilaginosa prosthetic valve endocarditis and review the literature of prosthetic device infections caused by this organism. CASE REPORTA 36-year-old man was admitted to the hospital in January 2012 with a chief complaint of left foot pain for 1 week. He described redness and swelling on the dorsum of his left foot. He denied trauma to the foot. He had been taking acetaminophen for pain intermittently without relief. He denied fever or chills, visual changes, back pain, muscle weakness, or numbness. He had a history of Streptococcus mitis mitral valve endocarditis and required mechanical mitral valve replacement in 2009. He had no history of peripheral vascular disease or claudication. He had no known drug allergies. His home medications included warfarin, methadone, and acetaminophen. He was an active intravenous heroin user. He was a former tobacco user with a 5-pack-year history who had quit 7 years before.On examination, the patient appeared well. His temperature was 100.9°F (38.3°C), pulse 108 beats per minute, blood pressure 133/64 mm Hg, and respirations 20 per minute. Cardiovascular examination revealed normal S1 and S2 and no murmurs, rubs, or gallops. The dorsum of the left foot had mild erythema, slight edema, and point tenderness of the mid-dorsal region. The left dorsalis pedis pulse was easily palpable. Skin examination revealed track marks at the right antecubital fossa. The remainder of the examination was normal. Laboratory studies revealed a white blood cell count of 20 ϫ 10 3 cells/mm 3 (reference range, 4 ϫ 10 3 to 11 ϫ 10 3 /mm 3 ), neutrophils at 88%, creatinine at 0.8 mg/dl, and an erythrocyte sedimentation rate of 35 mm/h (reference range, 0 to 10 mm/h). Other routine laboratory tests were normal. A leftfoot radiograph revealed no fracture, and an ultrasound of the left lower extremity revealed no deep vein thrombosis. Intravenous vancomycin and piperacillin-tazobactam were administered empirically for a presumptive diagnosis of left-foot cellulitis. The fever resolved, but the patient had persistent pain in the left foot, which subsequently turned blue and felt cold. Computed tomographic angiography revealed left popliteal artery thrombosis. A left popliteal thromboembolectomy was performed on day 4 of hospitalization. The pathology of the left popliteal thrombus revealed an organized thrombus with clusters of Gram-positive cocci. On day 4 of hospitalization, two sets of blood cultures obtained on the day of admission grew Rothia mucilaginosa from the aerobic bottles only.The organism was identified based upon biochemical tests, automated identification platforms (Phoenix system), and phenotypic characteristics. Gram stain revealed Gram-positive cocci that were catalase negative and grew sticky "staph-like" colonies which were whitish to gray in color, nonhemolyt...

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“…Rothia infections include bacteremia, endocarditis, meningitis, pneumonia, bone and joint infection, and cellulitis. Endocarditis is by far the most commonly reported infection [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

Uncommon Pathogen in an Unexpected Host: A Rare Case of Rothia mucilaginosa Infective Endocarditis in an Immunocompetent Patient Without an Underlying Valvular Disease

Abdelmaseih¹,

Abdelmasih²,

Faluk³

et al. 2021

Cureus

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Cerebral Mycotic Aneurysm Complicating Stomatococcus mucilaginosus Infective Endocarditis

Cited by 10 publications

References 30 publications

Anti‐biofilm and antibacterial activities of zinc oxide nanoparticles against the oral opportunistic pathogens Rothia dentocariosa and Rothia mucilaginosa

Anti‐biofilm and antibacterial activities of zinc oxide nanoparticles against the oral opportunistic pathogens Rothia dentocariosa and Rothia mucilaginosa

Rothia mucilaginosa Prosthetic Device Infections: a Case of Prosthetic Valve Endocarditis

Uncommon Pathogen in an Unexpected Host: A Rare Case of Rothia mucilaginosa Infective Endocarditis in an Immunocompetent Patient Without an Underlying Valvular Disease

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