Cerebral Microhemorrhage and Iron Deposition in Mild Cognitive Impairment: Susceptibility-weighted MR Imaging Assessment

Abstract

http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.10100612/-/DC1.

Individual Classification of Mild Cognitive Impairment Subtypes by Support Vector Machine Analysis of White Matter DTI

“…30,83 The classification accuracy of approximately 97% for all MCI subtypes in our series implies that only 1 subject was incorrectly classified, regardless of MCI subgroup. Note that the inclusion of a control group is not necessary for such individual-level classification analyses, as a classifier that perfectly discriminates, for example, 1 MCI subtype versus healthy controls may not necessarily also discriminate between the different MCI subtypes.…”

Clinicoradiologic Correlations of Cerebral Microbleeds in Advanced Age

“…In previous studies, greater or increasing numbers of CMBs with time were related to impaired cognitive functioning, in both cross-sectional 12,24 and longitudinal analyses 13,[33][34][35][36] in different types of cohorts (eg, population-based or in a memory clinic setting). The nature of the associations between CMBs and cognitive performance was, however, variable and not necessarily independent.…”

“…However, this is unlikely because no difference in CMB prevalence was found between subjects with MCI with stable and deteriorating conditions in a prior study. 36 Alternatively, structural damage reflected by isolated CMBs may not be important enough to impair clinically apparent locally associated functions, in contrast to the larger number of CMBs in vascular dementia and cerebral amyloid angiopathy (and Alzheimer disease). 1,3,4 In contrast to CMB, there has been rising interest in the correlation of declining cognitive function and another possible marker of small (and large) vessel disease in dementia, cortical microinfarcts.…”

Elevated brain iron is independent from atrophy in Huntington's Disease

“…Each of these techniques is simple to perform, but has significant potential limitations. A confounding factor of both T 2 -and T 2 ⁎ -based imagings is that measurements are also affected by changes in the water contentassociated for example with destructive brain processes (Bartzokis et al, 2004a) -and can mask the changes in iron content (Gelman et al, 1999;Haacke et al, 2005;Haller et al, 2010;Schenck and Zimmerman, 2004;Vymazal et al, 2007). Ex vivo histological staining of putamen samples from HD patients demonstrated elevated putamen iron levels (Chen et al, 1993) but there was little correlation to T 2 -weighted imaging of these samples.…”