Cerebral Metastasis in Patients with Uterine Cervical Cancer

Abstract

We report on eight patients who developed brain metastases following uterine cervical cancer. The mean interval between diagnosis of the primary cancer and diagnosis of the brain metastasis was 28.4 months (range: 6.1-61.8 months). Nausea and vomiting due to increased intracranial pressure were the most frequent symptoms. Surgical excision of the brain lesions, followed by postoperative radiotherapy, was performed in three patients. The other five patients received only cranial radiotherapy. When the metastatic brain lesions were detected, other distant metastatic lesions were confirmed at the same time in five patients. The median survival time after diagnosis of the brain metastases was only 3.0 months.

The impact of the stage and tumor size on rare brain metastasis of cervical cancer

“…Ikeda et al (7) reported that the initial stage was IIB in four of eight patients with brain metastasis from uterine cervical cancer. In a series of twelve cases from Chura et al (3), nine patients were stage IIB or below, while three patients were higher than stage IIB.…”

“…However, it is a rare development in uterine cervical cancer, with an incidence rate of only 0.4% to 1.2% (3,4,7,16). Recently, brain metastasis has been seen more frequently.…”

“…Despite the fact that metastatic brain tumors are said to constitute up to 50% of adult brain tumors, those arising from cervical cancer are a rare event, with an incidence rate between 0.4 to 1.2% among cervical cancer cases (3,4,7,13). Therefore, there are only case reports or small case series related to these rare metastases in the english medical literature (10)(11)(12)(15)(16)(17).…”

Metastases to the brain and to the skull base of carcinomas that are rarely metastasize to the central nervous system. Clinical and morphological analysis of 51 cases and literature review

“…В целом, МГМ рака яичников отграничены небольшими сериями и отдельными описаниями случаев, коих в ли-тературе на конец 2011 года насчитывалось не более 600 [15]. Рак шейки матки обычно имеет местное распространение и чаще дает метастазы по лимфатическим путям в забрюшинные лимфа-тические узлы [9,13]. МГМ рака шейки матки настолько редки, что в литературе встречают-ся лишь единичные описания случаев [4,5,13].…”

Combination of Abducens Nerve Palsy and Ipsilateral Postganglionic Horner Syndrome as an Initial Manifestation of Uterine Cervical Cancer

“…1) (20,21). On the other hand, uterine cervical cancer with brain metastasis is rare with an incidence of 0.44-1.18% (22)(23)(24), and there are no reports of intra-cavernous metastasis. Here, we describe a case presenting with this combination symptoms as an initial manifestation of uterine cervical cancer.…”