Cerebral Metabolism in Patients with Cognitive Disorders: a Combined Magnetic Resonance Spectroscopy and Positron Emission Tomography Study

Khomenko, Yu. G.; Катаева, Г. В.; Bogdan, A. A.; Chernysheva, E. M.; Susin, D. S.

doi:10.1007/s11055-019-00858-1

Cited by 4 publications

(3 citation statements)

References 27 publications

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“…The alteration in NAA/Cr between the 4th week of RT and 1-month post-RT showed a positive correlation with the alteration of the verbal fluency score of the ACE-R test between the 3-month and 6-month post-RT. Several studies showed that both NAA/Cr and Cho/Cr ratios are related to cognitive variables and correlated with verbal fluency in neurocognitive diseases [59][60][61]. The deviation of NAA/Cr at 1-month post-RT from 4th week of RT showed a positive correlation with the alteration in the visuospatial score of ACE-R test between the 3-month and the 6month post-RT.…”

Section: Discussionmentioning

confidence: 96%

“…It is consented that higher NAA/Cr as well as Cho/Cr ratios are associated with a better performance on logical as well as verbal memory. Cho/Cr is also correlated with the visual, the auditory, and verbal memory tests [ 60 ].…”

Section: Discussionmentioning

confidence: 99%

“…The imperative role of NAA in neural tissue has been established at more macroscopic levels, for example, toward understanding of the potential biochemical foundations of cognitive ability [ 67 ]. Studies have suggested that higher NAA and choline levels are associated with better cognitive function [ 60 , 68 ]. However, the higher creatine levels might better explain the correlations between NAA/Cr and Cho/Cr ratios and cognitive variables compared to absolute NAA or choline levels [ 69 ].…”

Section: Discussionmentioning

confidence: 99%

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Early Detection of Radiation-Induced Injury and Prediction of Cognitive Deficit by MRS Metabolites in Radiotherapy of Low-Grade Glioma

Alirezaei

Amouheidari

Hassanpour

et al. 2021

BioMed Research International

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Purpose. To compare the sensitivity of MRS metabolites and MoCA and ACE-R cognitive tests in the detection of radiation-induced injury in low grade glioma (LGG) patients in early and early delayed postradiation stages. Methods. MRS metabolite ratios of NAA/Cr and Cho/Cr, ACE-R and MoCA cognitive tests, and dosimetric parameters in corpus callosum were analyzed during RT and up to 6-month post-RT for ten LGG patients. Results. Compared to pre RT baseline, a significant decline in both NAA/Cr and Cho/Cr in the corpus callosum was seen at the 4th week of RT, 1, 3, and 6-month post-RT. These declines were detected at least 3 months before the detection of declines in cognitive functions by ACE-R and MoCA tools. Moreover, NAA/Cr alterations at 4th week of RT and 1-month post-RT were significantly negatively correlated with the mean dose received by the corpus callosum, as well as the corpus callosum 40 Gy dose volume, i.e., the volume of the corpus callosum receiving a dose greater than 40 Gy. Conclusion. MRS-based biomarkers may be more sensitive than the state-of-the-art cognitive tests in the prediction of postradiation cognitive impairments. They would be utilized in treatment planning and dose sparing protocols, with a specific focus on the corpus callosum in the radiation therapy of LGG patients.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%