Cerebral Metabolic, Hemodynamic and Antihypoxic Properties of <i>l</i>-Eburnamonine

Abstract

l-Eburnamonine - 16-oxoeburnane – assumes experimental cerebral ''oxygenator'' and antihypoxic properties which appear more pronounced than those of vincamine. In anesthetized dogs, l-eburnamonine increases the cerebral oxygen supply and the cerebral oxygen consumption, without cerebral vasodilation; l-eburnamonine improves the cerebral capillary circulation, as observed on the rheoencephalogram. l-Eburnamonine inhibits the effects of hypobaric hypoxia in mice (increase of survival time) and in rats (inhibition of amnesic effects of hypoxia). l-Eburnamonine decreases the electroencephalographic consequences of the acute and iterative asphyxic anoxia in curarized rats and, by means of the protection of the cerebral cortex, inhibits the postischemic increase of thalamic somesthetic evoked potentials in curarized cats. Further studies are necessary to precise the mechanisms involved in these ''cerebral protective'' properties of l-eburnamonine.

Comparison of the effects of vinpocetine, vincamine, and nicergoline on the normal and hypoxia‐damaged learning process in spontaneously hypertensive rats

“…Vincaminc, similarly to vinpocetine, did not improve learning in SH rats, but it afforded protection against hypoxia-induced learning deficit at the highest (20 mg/kg) dose. This limited antihypoxic effect is in contrast with some reports [Linee et al, 1978;DeNoble et al, 19861 where vincamine did not protect rats from hypobaric hypoxia-induced passive avoidance deficit, but this difference may be explained by different test conditions. Nicergoline did not significantly facilitate two-way active avoidance learning under normoxic conditions (except some improvement on day 2), contrary to some data in the literature where it improved the learning process in an operant conditioning task [Paul and Chandra, 19791.…”