Cerebral Malformations

Prayer, Daniela; Brugger, Peter C.; Nemec, Ursula; Milos, Ruxandra Iulia; Mitter, Christian; Kasprian, Gregor

doi:10.1007/174_2010_117

Cited by 7 publications

(30 citation statements)

References 109 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As the basal ganglia enlarge, the ventricles display their typical shape (Prayer et al, 2006). Abnormal width of the lateral ventricles may be the first sign of developmental anomalies (Prayer et al, 2011). For example, isolated mild ventriculomegaly (IMVM) is the most common brain abnormality on the prenatal ultrasound diagnosis and its potential changes of ventricular have been specified in an MRI study (Scott et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Spatial–temporal atlas of human fetal brain development during the early second trimester

Zhan¹,

Dinov²,

Li³

et al. 2013

NeuroImage

View full text Add to dashboard Cite

During the second trimester, the human fetal brain undergoes numerous changes that lead to substantial variation in the neonatal in terms of its morphology and tissue types. As fetal MRI is more and more widely used for studying the human brain development during this period, a spatiotemporal atlas becomes necessary for characterizing the dynamic structural changes. In this study, 34 postmortem human fetal brains with gestational ages ranging from 15 to 22 weeks were scanned using 7.0 T MR. We used automated morphometrics, tensor-based morphometry and surface modeling techniques to analyze the data. Spatiotemporal atlases of each week and the overall atlas covering the whole period with high resolution and contrast were created. These atlases were used for the analysis of age-specific shape changes during this period, including development of the cerebral wall, lateral ventricles, Sylvian fissure, and growth direction based on local surface measurements. Our findings indicate that growth of the subplate zone is especially striking and is the main cause for the lamination pattern changes. Changes in the cortex around Sylvian fissure demonstrate that cortical growth may be one of the mechanisms for gyration. Surface deformation mapping, revealed by local shape analysis, indicates that there is global anterior–posterior growth pattern, with frontal and temporal lobes developing relatively quickly during this period. Our results are valuable for understanding the normal brain development trajectories and anatomical characteristics. These week-by-week fetal brain atlases can be used as reference in in vivo studies, and may facilitate the quantification of fetal brain development across space and time.

show abstract

Section: Discussionmentioning

confidence: 99%

Spatial–temporal atlas of human fetal brain development during the early second trimester

Zhan¹,

Dinov²,

Li³

et al. 2013

NeuroImage

View full text Add to dashboard Cite

show abstract

“…In severe disorders of neuronal migration, such as lissencephaly, the different layers or zones of the fetal brain, for example, the ''lamination'' (Fig. 24 Thus, there are several technical issues that have to be addressed if performing fetal brain DWI: (1) the acquisition time of the DWI scan should be as short as possible (G20 seconds) to avoid significant fetal motion to occur; (2) the used maximum b-values should be rather low (b = 700 s/mm 2 ), which saves imaging time (compared to sequences with high b-values) and is most appropriate for the proton-rich fetal brain; and (3) DWI sequences should be acquired in strict orthogonal planes to allow for comparability between normal and abnormal findings. This results in an abnormal appearance on DWI, with abnormally high anisotropy of the subplate and, consequently, the loss of contrast between the subplate and the adjacent cortical plate or intermediate zone (Fig.…”

Section: Dwi Of Fetal Brain Pathologiesmentioning

confidence: 99%

Fetal Diffusion Imaging

Kasprian

Río²,

Prayer³

2010

Topics in Magnetic Resonance Imaging

Self Cite

View full text Add to dashboard Cite

Recently, diffusion-weighted (DWI) magnetic resonance imaging of the fetus has evolved from a basic research application to an important diagnostic imaging tool in fetal magnetic resonance imaging. Although technically challenging and still plagued with several sources of artifacts, DWI can add clinically important information, which cannot be provided by any other prenatal imaging modality. Its potential to noninvasively probe tissue structures on the basis of Brownian molecular motion enables the detection of early changes associated with acute fetal diseases, as well as structural alterations of functionally diverse compartments of different fetal organs. In this article, the current clinical applications of fetal brain and body DWI are outlined, as well as its current limitations.

show abstract

“…The fetal cerebral lateral ventricles show physiologic disproportionate enlargement of the occipital horns in relation to the frontal horns that remains until 23 WG; thereafter they gradually become smaller [18] . The standard measurement of the cerebral ventricle is obtained in an axial plane through the atrium [18,19] . Ventriculomegaly is diagnosed when the width of atria measures more than 10 mm [18] .…”

Section: Interpretation Of Fetal Mrimentioning

confidence: 99%

“…Congenital ventriculomegaly is a heterogeneous disease for which genetic, infectious, ischemic, and neoplastic causes have been implicated [20] . Because the prognosis of fetal ventriculomegaly is worse in presence of additional abnormalities, the prenatal detection of such abnormalities is critical [19] . MRI has an important role as an adjunctive tool to sonography in the evaluation of ventriculomegaly; it can rule out the diagnosis, confirm the finding or add associated abnormalities not amenable to sonographic diagnosis.…”

Section: Interpretation Of Fetal Mrimentioning

confidence: 99%

“…Axial and coronal MR images can provide indirect signs of complete agenesis of corpus callosum such as absent cavum septum pellucidum, straight parallel lateral ventricles, dilated occipital horns of lateral ventricles (colpocephaly), high riding third ventricle, and unformed cingulate sulcus [2] . Fetal MRI is useful in diagnosing dysplastic/agenetic septum pellucidum and any associated anomalies related to optic chiasm or pituitary as part of septo-optic dysplasia [19] . Holoprosencephaly is a midline brain anomaly characterized by variable severity of non-cleavage of cerebrum, agenesis of corpus callosum, and associated mid facial anomalies [8] .…”

Section: Interpretation Of Fetal Mrimentioning

confidence: 99%

See 1 more Smart Citation