Cerebral involvement in systemic lupus erythematosus (SLE): Comparison of positron emission tomography (PET) with other imaging methods

Meyer, G. J.; Schober, Otmar; Stoppe, G; Wildhagen, K.; Seidel, J; Hundeshagen, H.

doi:10.1016/0165-1781(89)90092-9

Cited by 18 publications

(10 citation statements)

References 5 publications

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“…38 However, PET is limited by its rigid technical requirements and high cost. 39 In contrast, MR imaging is relatively noninvasive and does not require the use of radioactive tracers, suggesting that it may be more practical for longitudinal follow-up studies and repeat assessments. 40 A previous study reported that the measurement derived from diffusion tensor imaging has been significantly correlated with the number of dopaminergic neurons lost in the substantia nigra in patients with PD.…”

mentioning

confidence: 99%

Usefulness of Quantitative Susceptibility Mapping for the Diagnosis of Parkinson Disease

Murakami¹,

Kakeda²,

Watanabe³

et al. 2015

AJNR Am J Neuroradiol

134

120

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mentioning

confidence: 99%

Usefulness of Quantitative Susceptibility Mapping for the Diagnosis of Parkinson Disease

Murakami¹,

Kakeda²,

Watanabe³

et al. 2015

AJNR Am J Neuroradiol

134

120

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“…The utility of F-18 FDG-PET/CT in patients with SLE has been limited to the central nervous system (2,3,4,5). In one study, PET scans showed hypometabolism in at least one brain region in all patients with severe or mild CNS symptoms (100%) and the authors decided that PET imaging represents a sensitive tool to detect manifest or subclinical CNS involvement in SLE and PET findings correlate well with the clinical course of disease (6).…”

Section: Literature Review and Discussionmentioning

confidence: 99%

Unusual F-18 FDG Uptake at the Ears of a Patient with Discoid Lupus Erythematosus

Özülker

Özülker²,

Cebeci³

et al. 2012

Mirt

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A 55-year-old patient, who had undergone excisional biopsy of upper lip two years ago and diagnosed to have squamous cell carcinoma, was referred to us for evaluation with Fluorine-18 fluorodeoxyglucose (F-18 FDG) positron emission tomography (PET)/CT (F-18 FDG-PET/CT) scan. F-18 FDG-PET/CT scan was performed and the maximum intensity projection images (MIP) showed unusual FDG uptake at both ears. Histopathological examination of the biopsy specimen obtained from the ears revealed discoid lupus erythematosus (DLE).Conflict of interest:None declared.

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“…Positron-emission tomography scanning, 31P MR spectroscopy, and singlephoton-emission computed tomography (SPECT) scanning have demonstrated profound, but reversible, disturbances in metabolic: activity and cerebral blood flow in patients with active NPSLE (26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37). T2-weighted MR images have reflected pathologic changes with variable degrees of sensitivity.…”

Section: Discussionmentioning

confidence: 99%

Spin‐spin relaxation of brain tissues in systemic lupus erythematosus

Sibbitt

Brooks

Haseler

et al. 1995

Arthritis & Rheumatism

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Objective. To correlate the spin-spin relaxation time (T2) of brain tissue in neuropsychiatric systemic lupus erythematosus (NPSLE) with the patient's clinical condition.Methods. T2 values were determined in 54 SLE patients and 45 non-SLE cointrols at 1.5 Tesla, using intensity from multi-echo magnetic resonance (MR) images fitted to an exponential decay curve with rateconstant T2.Results. The T2 of white matter was increased in SLE patients compared with controls (P = 0.01) and was increased in those patients who had previously experienced major NPSLE. Conclusion. Quantitative T2 measurement extends the utility and sensitivity of conventional MR imaging for evaluating NPSLE.Magnetic resonance imaging (MRI) has had an increasing role in the evaluation of neuropsychiatric (NP) symptoms associated with systemic lupus erythematosus (SLE) (1-10). MRI can detect the typical pathology of NPSLE, including focal and diffuse hyperintense lesions, infarcts, hemorrhage, and atrophy, with greater sensitivity than computed tomography (2,9). Although MRI provides excellent anatomic detail, interpretation is limited by the experience and objectivity of the observer, the discriminative ability of the human eye, and the inherent image contrast. MRI can provide quantitative data regarding the relaxation properties of water in different chemical environments induced by inflammatory diseases of the brain (1 1). Spin-lattice relaxation time (TI) and spin-spin relaxation time (T2) provide information regarding the total water in brain, the compartmentalization of brain water, and the degree of association between this water and macromolecules such as myelin and protein (12). The total quantity of water (proton density), T1, and T2 are responsible for the image intensity in both normal and abnormal tissues.Pathologic processes, including edema, infarction, and inflammation, usually increase both T2 and proton density. T2 values have been reported to be elevated in normal-appearing white matter of SLE patients and other patients with inflammatory brain disease (13). The current study determined the T2 values of cerebral lesions and normal-appearing brain

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Cerebral involvement in systemic lupus erythematosus (SLE): Comparison of positron emission tomography (PET) with other imaging methods

Cited by 18 publications

References 5 publications

Usefulness of Quantitative Susceptibility Mapping for the Diagnosis of Parkinson Disease

Usefulness of Quantitative Susceptibility Mapping for the Diagnosis of Parkinson Disease

Unusual F-18 FDG Uptake at the Ears of a Patient with Discoid Lupus Erythematosus

Spin‐spin relaxation of brain tissues in systemic lupus erythematosus

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