Cerebral Infarction due to a Spontaneous Tumor Embolus from Lung Cancer

Imaizumi, Kazuyoshi; Murate, Takanao; Ohno, Joji; Shimokata, Kaoru

doi:10.1159/000196412

Cited by 16 publications

(12 citation statements)

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“…Myxoma or other heart tumours (14-17) as well as lung tumours can be the source of embolism into the brain (18)(19)(20). The occlusion of a cerebral vessel can either cause an ischaemic stroke or give rise to arterial neoplastic aneurysms (21,22).…”

Section: Tumour Relatedmentioning

confidence: 99%

Stroke and cancer: a review

Grisold¹,

Oberndorfer²,

Struhal³

2009

Acta Neurologica Scandinavica

201

175

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Section: Tumour Relatedmentioning

confidence: 99%

Stroke and cancer: a review

Grisold¹,

Oberndorfer²,

Struhal³

2009

Acta Neurologica Scandinavica

201

175

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“…Several reports noted thrombus formation at the surgical stump, and the embolus source was identified in 13.5% of postsurgical resection cases. [ 4 , 5 , 7 , 9 ] In our patient, bronchial invasion of the lung carcinoma was present, and he underwent radiotherapy without prior surgery. We suspected the embolus migrated from an invasive lesion in the pulmonary vein, but no signs of this existed on the CT images acquired at admission or postthrombectomy.…”

Section: Discussionmentioning

confidence: 73%

A case of cerebral infarction due to pleomorphic carcinoma of the lung

Yoshikawa

Kamide

Kasakura

et al. 2020

Surgical Neurology International

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Background: With the increase in endovascular treatment, reports of embolism other than thrombus are scattered, but intracranial tumorigenic embolism is rare and difficult to diagnose. Here, we describe a case of a tumorigenic embolism in a patient with lung cancer whose invasion into the vascular system was not detected on preoperative whole-body imaging. Case Description: A 66-year-old man who was hospitalized to undergo radiotherapy for pulmonary carcinoma suddenly developed left hemiplegia. He exhibited atrial fibrillation, and emergent radiographic examination revealed a right middle cerebral artery occlusion. Urgent mechanical embolectomy was performed, with successful revascularization. The excised embolus had a unique morphology and was pathologically diagnosed as a cerebral embolism caused by pleomorphic pulmonary carcinoma. Conclusion: Tumor-derived cerebral embolism is extremely rare, but it is necessary to consider it as a potential source of embolism during differential diagnosis in patients with malignant tumors.

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“…Most of them are associated with primary or secondary pulmonary malignancies, which occurred during intraoperative and postoperative periods. Only 11 cases of histologically proven primary pulmonary malignancies have been reported, in which spontaneous arterial tumor embolism caused sudden onset of symptoms . Among them, tumor emboli were seen in common femoral artery in four cases; in multiple arteries further from aorta in two cases; and in coronary artery, iliac artery, posterior cerebral artery, left cerebral artery and profunda femoris artery, and visceral artery in one case each.…”

Section: Discussionmentioning

confidence: 99%

Massive tumor embolism in the abdominal aorta from pulmonary squamous cell carcinoma: Case report and review of the literature

Ohshima

Tsujii

Sakai

et al. 2017

Pathology International

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Acute arterial tumor embolism is a rare complication in cancer patients. Most of the previously reported cases of arterial tumor embolism have been associated with pulmonary malignancies and occurred during the intraoperative and postoperative periods. Very few cases occurred spontaneously. To our knowledge, there is no previous report of spontaneous and massive tumor embolism occluding the abdominal aorta in patients suffering from primary pulmonary carcinoma. We describe the case of 64-year-old man who presented with left homonymous hemianopsia and backache. Further evaluation revealed a mass in the right lung, severe coagulopathy, and cerebral hemorrhagic infarction in the right occipital lobe. He suddenly developed lower limb ischemia 4 weeks after his first clinical visit, and finally, died of multiple organ failure. Autopsy showed non-keratinizing squamous cell carcinoma in the right lung and massive tumor emboli in the abdominal aorta containing nests of squamous cell carcinoma. Infarct regions were found in the bilateral kidneys, spleen, liver, and brain; fibrin thrombi, but not tumor emboli, were found in these regions. This case suggested that tumor embolism should be considered when patients suffering from primary pulmonary malignancies develop arterial embolism and arterial tumor emboli could be massive enough to occlude the abdominal aorta.

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Cerebral Infarction due to a Spontaneous Tumor Embolus from Lung Cancer

Cited by 16 publications

References 0 publications

Stroke and cancer: a review

Stroke and cancer: a review

A case of cerebral infarction due to pleomorphic carcinoma of the lung

Massive tumor embolism in the abdominal aorta from pulmonary squamous cell carcinoma: Case report and review of the literature

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