2020
DOI: 10.3390/pathogens9030193
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Cerebral HSV-1 Vasculitis as a Fatal Complication of Immunosuppression in Non-Hodgkin´s Lymphoma: A Case Report and Review of the Literature

Abstract: Patients with lymphoma are predisposed to infection because of the immunocompromised state related to the disease itself and as a consequence of chemo-/radiotherapy. Here, we report a case of Herpes-simplex virus encephalitis (HSE) in an immunosuppressed patient with splenic marginal zone lymphoma (SMZL), a rare indolent variant of non-Hodgkin´s lymphoma (NHL). The course was complicated febrile neutropenia and HSV-1-related cerebral vasculitis causing progressive ischemic stroke. This case illustrates the exp… Show more

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Cited by 2 publications
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“…Infections can be complications of many non-communal diseases. Nardone et al describe a fatal case of a patient with non-Hodgkin´s lymphoma, where immune suppression led to cerebral HSV-1 vasculitis, causing progressive ischemic stroke [ 5 ]. This case report highlights the importance of the monitoring, prophylaxis and timely treatment of infections in immune-suppressed patients.…”
mentioning
confidence: 99%
“…Infections can be complications of many non-communal diseases. Nardone et al describe a fatal case of a patient with non-Hodgkin´s lymphoma, where immune suppression led to cerebral HSV-1 vasculitis, causing progressive ischemic stroke [ 5 ]. This case report highlights the importance of the monitoring, prophylaxis and timely treatment of infections in immune-suppressed patients.…”
mentioning
confidence: 99%