Cerebral hemorrhages in CADASIL: Report of four cases and a brief review

Rinnoci, Valentina; Nannucci, Serena; Valenti, Raffaella; Donnini, Ida; Bianchi, Silvia; Pescini, Francesca; Dotti, Maria Teresa; Federico, Antonio; Inzitari, Domenico; Pantoni, Leonardo

doi:10.1016/j.jns.2013.04.002

Cited by 42 publications

(27 citation statements)

References 22 publications

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“…Neuroimaging abnormalities such as cerebral white matter lesions (WMLs), lacunes, and microbleeds in the CADASIL patients are related to this cerebral small‐vessel histopathology 1. While CADASIL is considered a primarily ischemic form of vascular dementia, spontaneous intracerebral hemorrhage (ICH) has recently been reported in association with CADASIL,2, 3, 4, 5, 6 suggesting that the structural fragility of arterial walls may lead to ICH attacks. However, there are limited data describing the effects that the underlying structural changes related to CADASIL have on the occurrence of ICH and subsequent outcomes.…”

Section: Introductionmentioning

confidence: 99%

CADASIL: two new cases with intracerebral hemorrhage

Zhang

et al. 2017

Ann Clin Transl Neurol

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Whether cerebral autosomal‐dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a risk factor for spontaneous intracerebral hemorrhage (ICH) and influences outcomes remains unclear. In this study, we report two cases of CADASIL presenting with cerebral hemorrhages. These cases suggest that a CADASIL vasculopathy by itself mainly results in ICH, as indicated by slight vascular risk factors and prominent neuroimaging abnormalities, suggesting that CADASIL should be considered a risk factor for ICH. Interestingly, decreased perihematomal edema was noted in ICH patients with CADASIL in this study.

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Section: Introductionmentioning

confidence: 99%

CADASIL: two new cases with intracerebral hemorrhage

Zhang

et al. 2017

Ann Clin Transl Neurol

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“…Their preferential localization included cortical-subcortical regions, white matter, and the thalamus. [2][3][4] Microbleeds in patients with CADASIL and with a few small lesions in …”

Section: Discussionmentioning

confidence: 99%

Massive Pontine Microbleeds in a Patient With CADASIL

Kim

2014

JAMA Neurol

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“…Subcortical ischemic strokes (60-85%), cognitive impairment (40-50%), migraine with aura (20-40%), depression (20%), and apathy (40%) are the most prevalent symptoms 1 . An increased risk of intracerebral hemorrhage (ICH) has also been reported in these patients 3,4,5,6 . Clinical suspicion is based on typical symptoms, family history, and specific findings in magnetic resonance imaging (MRI) 1 .…”

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confidence: 97%

“…Increased risk of ICH in CADASIL patients is based on case reports and it has not been proved with controlled studies. Approximately 22 cases of ICH in CADASIL patients have been reported 3,4 . In our series, one hypertensive male treated with warfarin and one non-hypertensive woman treated with aspirin died after ICH.…”

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confidence: 99%

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Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) in Argentina

Hawkes

Wilken

Bruno

et al. 2015

Arq. Neuro-Psiquiatr.

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CADASIL is the most common cause of hereditary stroke and vascular dementia. Published information about this disease in South America is scant. We describe clinical and demographic characteristics of 13 patients (10 families) with CADASIL from Argentina.Methods Medical records, diagnostic tests and family history of patients with CADASIL were reviewed.Results Thirteen patients with CADASIL (10 families) were included. All patients had European ancestry. Initial presentation was stroke in most patients (n = 11). Stroke patients later developed cognitive complaints (n = 9), migraine with aura (n = 1), apathy (n = 4) and depression (n = 6). External capsule and temporal lobe involvement on MRI were characteristic imaging findings. Two patients died after intracerebral hemorrhage.Conclusion This is the first report of non-related patients with CADASIL in South America addressing ancestry. Since European ancestry is not highly prevalent in all South American countries, there may be variable incidence of CADASIL within this region.

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Cerebral hemorrhages in CADASIL: Report of four cases and a brief review

Cited by 42 publications

References 22 publications

CADASIL: two new cases with intracerebral hemorrhage

CADASIL: two new cases with intracerebral hemorrhage

Massive Pontine Microbleeds in a Patient With CADASIL

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) in Argentina

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