1960
DOI: 10.1001/archneur.1960.03840100077011
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Cerebral Hemorrhage in Leukemia

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1966
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Cited by 43 publications
(10 citation statements)
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“…This emphasizes the fact that a significant number of intracranial lesions do not manifest during life. The postmortem incidence of central nervous system complications seen in 45 cut of 82 (54.9%) patients in this series is high in comparison to the range from 19.35% to 49% reported in literature [11][12][13]. This variation may be due to a comparatively smaller number of patients' and a selective population studied by us.…”
Section: Discussioncontrasting
confidence: 58%
“…This emphasizes the fact that a significant number of intracranial lesions do not manifest during life. The postmortem incidence of central nervous system complications seen in 45 cut of 82 (54.9%) patients in this series is high in comparison to the range from 19.35% to 49% reported in literature [11][12][13]. This variation may be due to a comparatively smaller number of patients' and a selective population studied by us.…”
Section: Discussioncontrasting
confidence: 58%
“…9,[16][17][18][19][20][21][22][23][24] Most FICH occurred soon after diagnosis, 27 within 7 days, and 13 patients presented with FICH at diagnosis. Because the median interval from FICH to death was 2 days, we estimate that 1.6% of patients with acute leukemia die from FICH without any opportunity for proper management.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, viral infection of brain endothelial cells has been thought to cause cerebral hemorrhages, 31 but this could not be confirmed clinically. Thrombocytopenia, or platelet counts ranging from 20 000 to 40 000/ml, has been found to be a cause of cerebral hemorrhages, 16,30,32,33 and several centers have a restrictive platelet transfusion policy, with thresholds at 10 000 to 20 000/ml for patients with acute leukemia. 34,35 In contrast, we found that platelet counts less than 35 000/ml increased the risk of FICH.…”
Section: Discussionmentioning
confidence: 99%
“…Whereas very early studies had to rely on autopsies to establish a diagnosis of ICH [3], newer imaging modalities such as computed tomography (CT) have made it possible to diagnose ICH more quickly and of smaller sizes. Several studies so far have tried to describe the clinical characteristics of patients with ICH [24], but predictors of mortality in patients with leukemia who develop ICH are not available.…”
Section: Introductionmentioning
confidence: 99%