Cerebral cryptococcosys with depressive disorder

Artemieva, Marina S; Yurovskaya, I. I.; Gavrik, A. N.; Lukashenko, A. A.; Danilin, I.

doi:10.17116/jnevro20181184190-93

Cited by 2 publications

(1 citation statement)

References 3 publications

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“…Only a few preexisting studies have previously evaluated depression and cryptococcal meningitis. We found one case report of an HIV-positive individual with depression associated with cryptococcal meningitis 20 , a case series of HIV-negative individuals with cryptococcal meningitis 21 , and two case reports where HIV-statuses were not revealed 22,23 . We believe this is the first large study of depression following cryptococcal meningitis diagnosis, and the first randomized, controlled trial of a selective sertraline reuptake inhibitor (SSRI) in those with cryptococcal meningitis.…”

Section: Discussionmentioning

confidence: 99%

The effect of sertraline on depression and associations with persistent depression in survivors of HIV-related cryptococcal meningitis

et al. 2021

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Background: Depression is a risk factor for worse outcomes in persons living with HIV/AIDS and has a prevalence more than three times as high as in the general population. Despite this, there are few randomized studies of antidepressants in HIV-infected Africans. Methods: We enrolled 460 HIV-infected Africans with cryptococcal meningitis into a randomized clinical trial of adjunctive sertraline vs placebo (2015-2017). We defined depression using depression using a Center for Epidemiologic Studies Depression Scale (CES-D) score of >15, and severe depression as >26 at one and three months after meningitis diagnosis and initiation of treatment.We evaluated the relationship between sertraline and depression, as well as associations with persistent depression, at three months. Results: At one- and three-months post meningitis diagnosis, 62% (108/174) and 44% (74/169) of all subjects had depression (CES>15), respectively. At three months, sertraline-treated subjects had consistent risk for depression as placebo-treated subjects but were significantly less likely to have severe depression (CES>26) (OR 0.335; 95%CI, 0.130-0.865). Of those with depression at one month, sertraline-treated subjects were less likely than placebo-treated subjects to be depressed at three months (p=0.05). Sertraline was the only factor we found significant in predicting persistent depression at three months among those who had depression at one month. Conclusions: Depression is highly prevalent in HIV-infected persons who have survived cryptococcal meningitis. We found that sertraline is associated with a modest reduction in depression in those with depression at baseline and a significant decrease in severe depression.

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Section: Discussionmentioning

confidence: 99%

The effect of sertraline on depression and associations with persistent depression in survivors of HIV-related cryptococcal meningitis

et al. 2021

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Features of diagnosis of inflammatory lesions of central nervous system in HIV-infected patients at terminal stage of disease: clinical case

Karakulova

Seksyaev

Sosnin

2021

Perm Medical Journal

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The authors of the article describe a case of the damage to the central nervous system by fungi of the genus Cryptococcus in a HIV-infected patient. The features of clinical manifestations and laboratory diagnostics are characterized. Special attention is paid to the discrepancy between the sharply changed appearance of the cerebrospinal fluid obtained during lumbar puncture and the clinical picture of the disease as well as the data of laboratory analysis of cerebrospinal fluid.

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Cerebral cryptococcosys with depressive disorder

Cited by 2 publications

References 3 publications

The effect of sertraline on depression and associations with persistent depression in survivors of HIV-related cryptococcal meningitis

The effect of sertraline on depression and associations with persistent depression in survivors of HIV-related cryptococcal meningitis

Features of diagnosis of inflammatory lesions of central nervous system in HIV-infected patients at terminal stage of disease: clinical case

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