Cerebral cortical thickness in patients with type 2 diabetes

Brundel, Manon; Heuvel, Martijn P. van den; Bresser, Jeroen de; Kappelle, L. Jaap; Biessels, Geert Jan

doi:10.1016/j.jns.2010.08.048

Cited by 127 publications

(127 citation statements)

References 24 publications

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“…The analysis of the mean cortical thickness of whole brain demonstrated that cortical thicknesses of both hemisphere in the patients with T2DM were thinner than those of the normal controls, which is consistant with the study by Brundel et al, 27 suggesting brain injury induced by the disease. However, the measurements of mean cortical thickness in diabetic patients in our study were thicker than those in Brundel's study.…”

Section: Discussionsupporting

confidence: 85%

16例新发2型糖尿病患者脑部皮层厚度异常变化的mri初步研究

Chen

Zang

et al. 2017

cmsj

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Objective The aim of this study is to investigate the cerebral cortical thickness changes in type 2 diabetes mellitus (T2DM) using a whole brain cortical thickness mapping system based on brain magnetic resonance imaging (MRI).Methods High resolution three-dimensional T1-weighted fast spoiled gradient recalled echo MR images were obtained from 16 patients with T2DM, as well as from 16 normal controls. The whole brain cortical thickness maps were generated, and the cortical thickness of each brain region was calculated according to gyral based regions of interest (ROI) using an automated labeling system by the Freesurfer software. We compared mean cortical thickness at each brain region by the analysis of covariance with age and sex as covariates. The regional difference of the cortical thickness over the whole brain was compared by the analysis of surface-based cortical thickness.Results Mean cortical thicknesses analysis showed bilateral cerebrum in the patients with T2DM (left: 2.52±0.07 mm; right: 2.51±0.08 mm) were significant thinner than those in the normal controls (left: 2.56±0.09 mm; right: 2.56±0.09 mm) (both P<0.05). Regional cortical thinning in T2DM was demonstrated in the paracentral lobule, postcentral gyrus, lateral occipital gyrus, lingual gyrus, precuneus, superior temporal gyrus, middle temporal gyrus, inferior temporal gyrus and posterior cingulate gyrus, compared to the normal controls. The cortical thickness of left middle cingulate and right inferior temporal gyrus were negatively correlated with the disease course.Conclusion A widespread cortical thinning was revealed in patients with T2DM by the analysis of brain cortical thickness on MR. Our finding supports the idea that T2DM could lead to subtle diabetic brain structural changes.Chin Med Sci J 2017; 32(2):75-82.

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Section: Discussionsupporting

confidence: 85%

16例新发2型糖尿病患者脑部皮层厚度异常变化的mri初步研究

Chen

Zang

et al. 2017

cmsj

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“…The cognitive impairment prevalence was found to be significantly higher in people with both T2DM and hypertension than in those normotensive T2DM patients [44]. Small vessel disease not only could predict future cognitive decline in elderly people with T2DM [45] but also was associated with the hippocampal atrophic changes [46] (Figure 1). Further, accelerated cognitive decline in patients with T2DM was associated with vascular damages [47]; arterial stiffness was increased and significantly associated with cognition impairments in T2DM patients [16].…”

Section: Pathological Mechanisms Underlying the Impaired Cognition Fumentioning

confidence: 97%

An Update on Type 2 Diabetes Mellitus as a Risk Factor for Dementia

Huang

2016

JAD

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“…If there was possible overlap but different results were presented, for example hippocampus presented in one study and frontal lobe in the other, all data were included. The following 9 studies were assimilated into 4 studies because of potential sample overlap: i) Brundel et al 2010;de Bresser et al 2010 andJongen et al 2007; ii) Anan et al 2010 andAnan et al 2011;iii) Manor et al 2012 andNovak et al 2011;iv) Hershey et al 2010 andPerantie et al 2011.…”

Section: Data Extractionmentioning

confidence: 99%

“…Regional reductions were revealed in orbitofrontal cortex grey matter (Table 3, We also examined potential longitudinal changes, which was possible for total brain volume from 2 studies (n = 113 patients, mean age 65.9 years; n=668 controls, mean age 78.1 years) (de Bresser et al 2010;Espeland et al 2013). Accelerated brain atrophy was evident in older T2DM patients relative to age-matched healthy controls (Hedges' g = -0.25 95% CI (-0.49;-0.02); z=2.16, p=0.03) with a follow-up period of 4.7 and 4.1 years respectively.…”

Section: Type 2 Diabetesmentioning

confidence: 99%

Meta-analyses of structural regional cerebral effects in type 1 and type 2 diabetes

Moulton

Costafreda

Horton

et al. 2015

Brain Imaging and Behavior

128

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Diabetes is associated with macrovascular and microvascular complications and is a major risk factor for neurological and psychiatric disorders, such as dementia and depression. Type 1 diabetes (T1DM) and type 2 diabetes (T2DM) have distinct etiologies and pathophysiological effects while sharing a common endpoint of persistent hyperglycemia.Neuroimaging studies in T1DM have revealed reductions in numerous regions, including the parahippocampal and occipital regions, while in T2DM there have been numerous reports of hippocampal atrophy. This meta-analysis aimed to identify consistent regional abnormalities in cerebral structures in T1DM and T2DM respectively, and also to examine the impact of potential confounds, including age, depression and vascular risk factors. Neuroimaging studies of both voxel-based morphometry (VBM) data and volumetric data were included.Ten T1DM studies (n=613 patients) and 23 T2DM studies (n=1364 patients) fulfilled inclusion criteria. The T1DM meta-analysis revealed reduced bilateral thalamus grey matter density in adults. The T2DM meta-analysis revealed reduced global brain volume and regional atrophy in the hippocampi, basal ganglia, orbitofrontal and occipital lobes.Moreover, hippocampal atrophy in T2DM was not modified by hypertension, although there were more marked reductions in younger patients relative to healthy controls. In conclusion, T1DM and T2DM demonstrated distinct cerebral effects with generalised and specific target areas of grey matter reduction. Thalamic atrophy in T1DM may be a substrate of associated cognitive deficits. In T2DM, global cerebral atrophy may reflect atherosclerotic factors, while hippocampal atrophy was an independent effect providing a potential common neuropathological aetiology for the comorbidity of T2DM with dementia and depression.

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Cerebral cortical thickness in patients with type 2 diabetes

Cited by 127 publications

References 24 publications

16例新发2型糖尿病患者脑部皮层厚度异常变化的mri初步研究

16例新发2型糖尿病患者脑部皮层厚度异常变化的mri初步研究

An Update on Type 2 Diabetes Mellitus as a Risk Factor for Dementia

Meta-analyses of structural regional cerebral effects in type 1 and type 2 diabetes

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