Cerebral Cortical Oxygenation and Perfusion during Hetastarch Hemodilution

Shinozuka, T; Nemoto, Edwin M.; Bleyaert, Achiel L.

doi:10.1007/978-1-4684-4895-5_83

Cited by 9 publications

(2 citation statements)

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“…Although our results did not include the cerebral oxygen transport, cerebral oxygen transport is reported to be maintained until the Hct value of 31% or 32% in dogs with or without cerebral ischemia (5,14). The study by Shinozuka et al performed in rats is also in line with this study (15). Shinozka et al measured the change in the cerebral cortical tissue oxygen tension during haemodilution.…”

Section: Discussionsupporting

confidence: 91%

The effect of acute normovolemic haemodilution on cerebral oxygenation

Han

Ham

et al. 2004

International Journal of Clinical Practice

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Acute normovolemic haemodilution (ANH) may cause an imbalance in cerebral oxygen metabolism because it decreases the arterial oxygen content. This study was designed to investigate the effect of ANH on cerebral oxygenation. By using cerebral oximetry, the regional cerebral oxygen saturation (rSO2) was monitored during ANH in 26 patients without systemic illness (initial haematocrit = 42 +/- 1%). The rSO2 did not show a significant change until the Hct reached >30%. However, it decreased significantly thereafter to reach 88% of the baseline value when the ANH was completed with a Hct value of 24 +/- 1% (before ANH; 71 +/- 6% vs. after ANH; 62 +/- 4%, p < 0.01). In conclusion, an ANH can lead to a reduction in cerebral oxygenation when a patient's Hct goes below 30%.

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Section: Discussionsupporting

confidence: 91%

The effect of acute normovolemic haemodilution on cerebral oxygenation

Han

Ham

et al. 2004

International Journal of Clinical Practice

View full text Add to dashboard Cite

show abstract

“…Although the cerebral blood flow (CBF) increases in response to ANH (9, 10), it does not necessarily guarantee cerebral tissue oxygenation, as ANH also causes a decrease in arterial oxygen content (9, 11). Our group A results are consistent with the observation that an Hct value of 30–33% maintains cerebral oxygen metabolism (12, 13) or the r S O 2 value (8).…”

Section: Discussionsupporting

confidence: 84%