Cerebral Correlates of the Progression Rate of the Cognitive Decline in Probable Alzheimer’s Disease

Nagahama, Yasuhiro; Nabatame, Hidehiko; Okina, Tomoko; Yamauchi, Hiroshi; Narita, Minoru; Fujimoto, Naoki; Murakami, Motonobu; Fukuyama, Hidenao; Matsuda, Minoru

doi:10.1159/000070851

Cited by 67 publications

(39 citation statements)

References 37 publications

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“…For greater levels of conflict, such as those experienced during both the preparation and decision phase of the task after the red cue, the cognitive demands might have exceeded the MCI's compensatory reserve, thus yielding a next to null load-related response in dlPFC. The weak response of dlPFC to the load of the task observed in MCI may reflect frontal lobe neural degeneration (Encinas et al 2003;Nagahama et al 2003) in MCI.…”

Section: Discussionmentioning

confidence: 99%

Event-related functional magnetic resonance imaging investigation of executive control in very old individuals with mild cognitive impairment

Rosano

Aizenstein

Cochran

et al. 2005

Biological Psychiatry

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Background-Attentional control of executive cognitive function (ECF) decreases in older individuals with Alzheimer Disease (AD). In order to examine early AD-related changes in the neural substrates of ECF attentional control, we measured activation dorsolateral prefrontal (dLPFC), posterior parietal (PPC), and anterior cingulate cortex (ACC) in adults with mild cognitively impairment (MCI) and in cognitively normal (CN) adults.

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Section: Discussionmentioning

confidence: 99%

Event-related functional magnetic resonance imaging investigation of executive control in very old individuals with mild cognitive impairment

Rosano

Aizenstein

Cochran

et al. 2005

Biological Psychiatry

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show abstract

“…Efficient cerebral blood flow is also vital for optimal brain function, with several studies indicating that there is a decrease in cerebral blood flow (CBF) in patients with dementia [71,87]. Brain imaging techniques, such as 'functional magnetic resonance imaging' (fMRI) and 'trans-cranial Doppler ultrasound' (TCD) has shown that there is a correlation between CBF and cognitive function Fig.…”

Section: Cerebrovascular Effects Of Flavonoidsmentioning

confidence: 99%

The neuroprotective potential of flavonoids: a multiplicity of effects

et al. 2008

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Flavonoids exert a multiplicity of neuroprotective actions within the brain, including a potential to protect neurons against injury induced by neurotoxins, an ability to suppress neuroinflammation, and the potential to promote memory, learning and cognitive function. These effects appear to be underpinned by two common processes. Firstly, they interact with critical protein and lipid kinase signalling cascades in the brain leading to an inhibition of apoptosis triggered by neurotoxic species and to a promotion of neuronal survival and synaptic plasticity. Secondly, they induce beneficial effects on the vascular system leading to changes in cerebrovascular blood flow capable of causing angiogenesis, neurogenesis and changes in neuronal morphology. Through these mechanisms, the consumption of flavonoid-rich foods throughout life holds the potential to limit neurodegeneration and to prevent or reverse age-dependent loses in cognitive performance. The intense interest in the development of drugs capable of enhancing brain function means that flavonoids may represent important precursor molecules in the quest to develop of a new generation of brain enhancing drugs.

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“…Indeed, new hippocampal cells are clustered near blood vessels, proliferate in response to vascular growth factors and may influence memory [49]. Efficient cerebral blood flow (CBF) is vital for optimal brain function, with several studies indicating that there is a decrease in CBF in patients with dementia [48,52]. Brain imaging techniques, such as 'functional magnetic resonance imaging' (fMRI) and 'trans-cranial Doppler ultrasound' (TCD) has shown that there is a correlation between CBF and cognitive function in humans [52].…”

Section: Modulation Of Memory and Learningmentioning

confidence: 99%

Flavonoids and brain health: multiple effects underpinned by common mechanisms

2009

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The neuroprotective actions of dietary flavonoids involve a number of effects within the brain, including a potential to protect neurons against injury induced by neurotoxins, an ability to suppress neuroinflammation, and the potential to promote memory, learning and cognitive function. This multiplicity of effects appears to be underpinned by two processes. Firstly, they interact with important neuronal signalling cascades leading to an inhibition of apoptosis triggered by neurotoxic species and to a promotion of neuronal survival and differentiation. These interactions include selective actions on a number of protein kinase and lipid kinase signalling cascades, most notably the PI3K/Akt and MAP kinase pathways which regulate pro-survival transcription factors and gene expression. Secondly, they induce peripheral and cerebral vascular blood flow in a manner which may lead to the induction of angiogenesis, and new nerve cell growth in the hippocampus. Therefore, the consumption of flavonoid-rich foods, such as berries and cocoa, throughout life holds a potential to limit the neurodegeneration associated with a variety of neurological disorders and to prevent or reverse normal or abnormal deteriorations in cognitive performance.

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Cerebral Correlates of the Progression Rate of the Cognitive Decline in Probable Alzheimer’s Disease

Cited by 67 publications

References 37 publications

Event-related functional magnetic resonance imaging investigation of executive control in very old individuals with mild cognitive impairment

Event-related functional magnetic resonance imaging investigation of executive control in very old individuals with mild cognitive impairment

The neuroprotective potential of flavonoids: a multiplicity of effects

Flavonoids and brain health: multiple effects underpinned by common mechanisms

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