Cerebral collateral circulation and acute ischaemic stroke

Gill, D.

doi:10.1111/ene.13117

Cited by 4 publications

(4 citation statements)

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“…Collateral circulation refers to the network of blood vessels that contribute towards maintaining blood flow in the absence of the primary conduit [16]. The degree of such collateral blood supply varies amongst individuals and can influence outcomes, especially in patients with AIS due to LVO [16].…”

Section: Discussionmentioning

confidence: 99%

“…The degree of such collateral blood supply varies amongst individuals and can influence outcomes, especially in patients with AIS due to LVO [16]. Patients with good collateral flow demonstrated less hypoperfused tissue, less infarct growth within the penumbra zone, and smaller infarct volumes with better outcomes than those with poor collaterals [17].…”

Section: Discussionmentioning

confidence: 99%

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Proteomic profiling of plasma biomarkers in acute ischemic stroke due to large vessel occlusion

et al. 2019

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Background Acute ischemic stroke (AIS) due to large vessel occlusion (LVO) is a devastating cerebrovascular disorder, which could benefit from collateral circulation. Proteins associated with acute LVO pathogenesis and endothelial function may appear in blood samples of AIS patients due to LVO, thus permitting development of blood-based biomarkers for its diagnosis and prognosis. Methods This study is a single-center, retrospective, observational case–control trial. Consecutive patients who presented at the Department of Neurology of Tongji Hospital were recruited from July 2016 to April 2018. In the discovery phase, a proteomic approach with iTRAQ-based LC–MS/MS was used to investigate the altered proteomic pattern in plasma from patients with AIS due to LVO. In the validation study, Western blots was used to identify biomarkers associated with stroke diagnosis as well as their prognostic value associated with different collateral statuses. Results For this exploratory study, the proteomic analysis of plasma from 40 patients with AIS due to LVO and 20 healthy controls revealed seven differentially expressed proteins with a 1.2/0.83-fold or greater difference between groups. The four elevated proteins, PPBP (1.58 ± 0.78 vs 0.98 ± 0.37; P < 0.001), THBS1 (1.13 ± 0.88 vs 0.43 ± 0.26; P < 0.001), LYVE1 (1.61 ± 0.55 vs 0.97 ± 0.50; P < 0.001), and IGF2 (1.19 ± 0.42 vs 0.86 ± 0.24; P < 0.001), were verified by Western blots analysis in an independent cohort including 33 patients and 33 controls. A strong interaction was observed between the four-protein panel and the diagnosis of AIS due to LVO (AUC 0.947; P < 0.001). Furthermore, IGF2, LYVE1, and THBS1 were closely associated with collateral status (IGF2 0.115, 95% CI 0.016–0.841, P = 0.033; LYVE1 0.183, 95% CI 0.036–0.918, P = 0.039; THBS1 4.257, 95% CI 1.273–14.228, P = 0.019), and proved to be independent predictors of good outcome (IGF2 0.115, 95% CI 0.015–0.866, P = 0.036; LYVE1 0.028, 95% CI 0.002–0.334, P = 0.005; THBS1 3.294, 95% CI 1.158–9.372, P = 0.025) at a 3-month follow-up. Conclusions The identified 4-biomarker panel could provide diagnostic aid to the existing imaging modalities for AIS due to LVO, and the prognostic value of IGF2, LYVE1, and THBS1 was proved in predicting functional outcomes related to collateral status. Trial registration ClinicalTrials.gov NCT 03122002. Retrospectively registered April 20, 2017. URL of trial registry record: https://www.clinicaltrials.gov/ct2/show/NCT03122002?term=NCT+03122002&rank=1 Electronic supplementary material The online version of this article (10.1186/s12967-019-1962-8) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Proteomic profiling of plasma biomarkers in acute ischemic stroke due to large vessel occlusion

et al. 2019

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“…Singer et al [ 38 ] found that the earlier the onset age and the lower the NIHSS score, the better the prognosis of patients. Good CC has also been shown to significantly reduce cerebral infarction volume in patients with symptomatic intracranial atherosclerotic stenosis and lower the risk of cerebral infarction recurrence [ 39 , 40 ]. Besides, the degree of CC opening before illness can affect the clinical prognosis of patients more than that after illness [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Application of Three-Dimensional Arterial Spin Labeling Technique in the Assessment of Cerebral Blood Perfusion in Patients with Middle Cerebral Artery Occlusion: Analysis of Clinical Implications and Prognostic Factors

Zhou¹,

Fu²,

Meng³

et al. 2022

Disease Markers

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Objective. To explore the value of three-dimensional- (3D-) arterial spin labeling (ASL) technique in evaluating cerebral perfusion in patients with unilateral middle cerebral artery occlusion (MCAO) and to observe the influencing factors of poor prognosis via long-term follow-up of patients who survived the disease. Methods. The clinical data of 60 patients with unilateral middle cerebral artery (MCA) M1 segment occlusion diagnosed by magnetic resonance angiography (MRA) from January 2018 to January 2022 were retrospectively analyzed. All patients were examined by routine MRI, MRA, and 3D-ASL, in which two postlabeling delays (PLDs; 1525 ms and 2525 ms) were used in 3D-ASL. Cerebral blood flow (CBF) in the regions of interest (ROIs) of MCA on the affected side and the mirror side was measured. The clinical data and laboratory indexes of patients were collected and evaluated by clinical scales. With the modified Rankin Score (mRS) as the outcome indicator, patients were assigned to either the poor or the good prognosis group to analyze the factors influencing patient prognosis via univariate and multivariate analyses. Results. Among unilateral MCAO patients, there was a significant difference in the CBF of the affected side between the PLD 1525 ms and 2525 ms groups ( P < 0.05 ), but there was no significant difference in the CBF of the mirror side ( P > 0.05 ). Compared with the mirror side, 43 cases (71.7%) of the affected CBF presented with hypoperfusion, 9 cases (15.0%) with normal perfusion, and 8 cases (13.3%) with hyperperfusion. Age, NIHSS score, collateral circulation, and homocysteine (Hcy) were identified by multivariate Logistic regression analysis as independent risk factors for adverse outcomes. Conclusion. MCAO can lead to cerebral blood perfusion decline, and 3D-ASL technique can evaluate the post-MCAO cerebral blood perfusion level. Old age, high NIHSS scores, poor collateral circulation, and high Hcy levels are associated with poor clinical outcomes.

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“…Stroke represents the largest proportion of papers published, including those on pathophysiology , acute stroke management and the outcome of patients who have suffered stroke . Stroke is a worldwide problem, but its prevalence varies and may reflect both the genetic and environmental contributions to stroke, both in turn reflecting the known risk factors for stroke.…”

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confidence: 99%

Advances and insights into neurological practice 2016−17

Schapira¹

2017

Euro J of Neurology

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Cerebral collateral circulation and acute ischaemic stroke

Abstract: Click http://onlinelibrary.wiley.com/doi/10.1111/ene.13111/abstract to view the accompanying paper in this issue.

Cited by 4 publications

References 8 publications

Proteomic profiling of plasma biomarkers in acute ischemic stroke due to large vessel occlusion

Proteomic profiling of plasma biomarkers in acute ischemic stroke due to large vessel occlusion

Application of Three-Dimensional Arterial Spin Labeling Technique in the Assessment of Cerebral Blood Perfusion in Patients with Middle Cerebral Artery Occlusion: Analysis of Clinical Implications and Prognostic Factors

Advances and insights into neurological practice 2016−17

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