Cerebral Cladosporiosis

Sandhyamani, S; Bhatia, Ravi; Mohapatra, L. N.; Roy, S.

doi:10.1016/s0090-3019(81)80030-4

Cited by 20 publications

(3 citation statements)

References 8 publications

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“…These are pigmented fungi containing melanin pigment that are indistinguishable in tissue sections and can be differentiated by cultural characteristics only 30 . Only a few cases have been reported from India 1,11 , 30–33 …”

Section: Discussionmentioning

confidence: 99%

Pathology of fungal infections of the central nervous system: 17 years' experience from Southern India

et al. 2006

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Section: Discussionmentioning

confidence: 99%

Pathology of fungal infections of the central nervous system: 17 years' experience from Southern India

et al. 2006

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“…The first report of this clinical entity from India was by Bagchi et al [164] and the first culture-proven case was by Dastur et al [165] This was followed by sporadic reports from other centers with no predilection for race or geographic location. [166][167][168][169] A cerebral abscess caused by Fonsecaea pedrosoi, a rare chromomycotic infection was reported from NIMHANS, Bangalore. [170] Most infections of pheohyphomycosis occurred in the second and third decade, the youngest case documented was in a six-day-old neonate.…”

Section: Indian Data [Table 4]mentioning

confidence: 99%

Pathobiology of fungal infections of the central nervous system with special reference to the Indian scenario

et al. 2007

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Ubiquitously present fungi in the environment find a nidus in the human body and adopt its metabolic machinery to be in symbiosis or become pathogenic. Immunocompromised states like human immunodeficiency virus (HIV) / acquired immunodeficiency syndrome (AIDS), systemic neoplasia and organ transplantation have enhanced the frequency of fungal infections. High-risk behavior, IV drug abuse and air travel have led to the emergence of new fungal infections hitherto geographically localized. The pathology in the central nervous system (CNS) is dictated largely by the size of the fungus - the yeast forms, by virtue of their small size enter the microcirculation to cause meningitis and microabscesses, while hyphal forms invade the vasculature to manifest as large pale or hemorrhagic infarcts. The growth kinetics of fungi, the antigenic character of the capsule. the proteases secreted by the mycelial forms and the biochemical milieu in the host also determine clinical manifestations. A hospital-based analysis of the available information from India suggests that in the non-HIV patient population, hyphal forms like Aspergillosis and Zygomycosis are the most common pathogens, while yeast forms like Cryptococcus and Candida are the prime pathogens in cases of HIV/AIDS, the altered macrophage function acting in synergy with suppressed cell-mediated immunity. In Northeastern states, systemic infection by Penicillium marneffei is reported in association with HIV though CNS involvement is not recorded. Although fungal infections of the CNS are reported from various hospitals in India, studies are limited by non-availability of relevant microbiological studies and the reported prevalence data is biased by the surgical practices, availability of postmortem and microbiology and laboratory support. Detailed clinical and mycological investigations related to the interaction between the fungus and host environment is a fertile area of research to understand the basic pathogenetic mechanisms.

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“…Se analizaron 58 informes de caso procedentes de 48 artículos científicos [ 21 - 68 ] ( Tabla ), de los cuales los países con mayores informes de caso fueron India, con 32 casos, y Estados Unidos, con 11 casos ( Fig. 2 ).…”

Section: Resultsunclassified

Infección micótica por Cladophialophora bantiana y desarrollo de feohifomicosis cerebral. Revisión sistemática de 58 informes de caso

Jara Ortega,

Ordoñez Apolo,

Jara Ortega

et al. 2023

RevNeurol

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Introducción. Cladophialophora bantiana es un hongo filamentoso, denominado hongo dematiáceo por la presencia de melanina. Este hongo tiene importancia clínica por ser neurotrópico y causar feohifomicosis cerebral. Material y métodos. Se analizó la información científica disponible sobre el desarrollo de feohifomicosis cerebral provocada por Cladophialophora bantiana , seleccionando artículos de las bases de PubMed, Scopus y Google Scholar, que describen informes de caso sobre infección micótica de C. bantiana en adultos, considerando el análisis de la sintomatología, el historial clínico y los daños neuroanatómicos de los pacientes, además de considerar la mortalidad de la patología. Resultados. La India y Estados Unidos fueron los países con más informes de caso, 32 y 11 casos, respectivamente. Asimismo, en cuanto a las lesiones neuroanatómicas, en su mayoría, los pacientes sufrieron lesiones mixtas (29%) y del lóbulo frontal (22%). De acuerdo con el estado de los pacientes, la patología tiene una mortalidad del 62%. Conclusiones. Se concluye que la feohifomicosis cerebral tiene una alta mortalidad, no existe un tratamiento estandarizado y, en la mayoría de los casos, la infección fúngica del cerebro es mixta y afecta a varias partes del cerebro; además, si no se diagnostica y trata a tiempo, puede ocasionar la muerte de los pacientes.

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Cerebral Cladosporiosis

Cited by 20 publications

References 8 publications

Pathology of fungal infections of the central nervous system: 17 years' experience from Southern India

Pathology of fungal infections of the central nervous system: 17 years' experience from Southern India

Pathobiology of fungal infections of the central nervous system with special reference to the Indian scenario

Infección micótica por Cladophialophora bantiana y desarrollo de feohifomicosis cerebral. Revisión sistemática de 58 informes de caso

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