Cerebral calculi in the temporal horn of the lateral ventricle: report of an unusual case

Ghosal, Nandita; Thakre, Darpan J.; Murthy, Ganesh; Hegde, Alangar S.

doi:10.1111/j.1365-2559.2007.02670.x

Cited by 15 publications

(8 citation statements)

References 3 publications

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“…The frequent adjacent granulomatous and inflammatory reaction along with an indolent course and a generally good prognosis support a benign or reactive rather than neoplastic process . Of the 65 cases of CAPNON that we identified in the literature, only one case presented with two separate lesions diagnosed 8 years apart in the same individual . The remaining 64 cases were solitary.…”

Section: Introductionmentioning

confidence: 77%

“…This entity shows male predominance (1.92:1) but does not seem to have a predilection for an age group . Sixty‐five cases have been reported in the literature, 41 of which were intracranial and mostly intradural, 20 in the spinal canal and four at the craniovertebral junction . Of the 65 reported cases, 64 cases consisted of a solitary lesion, while only one case presented with one initial lesion and the second many years later …”

Section: Discussionmentioning

confidence: 99%

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Multiple calcifying pseudoneoplasms of the neuraxis (MCAPNON): Distinct entity, CAPNON variant, or old neurocysticercosis?

Abdaljaleel

Mazumder

et al. 2016

Neuropathology

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We report a case of multiple calcifying pseudoneoplasms of the neuraxis (MCAPNON) with associated multifocal perivascular microcalcifications and vascular calcinosis. Calcifying pseudoneoplasm of the neuraxis (CAPNON) is a very rare condition that may arise in extra-axial and occasionally, in intra-axial locations. Moreover, it is nearly always a solitary mass with only one case with two lesions reported. While the etiology and pathogenesis of CAPNON remains unclear, the histopathology findings of this entity have been well described. We report a case of a 62-year-old woman with 18 calcifying radiologic lesions involving bilateral cerebral hemispheres. Histologically, these lesions have features similar to that reported for CAPNON, including nodular calcification with fibro-osseous components and peripheral histiocytic reaction. The patient had a poorly documented diagnosis of neurocyticercosis 32 years prior, although without tissue confirmation. The lack of detectable cysticercus serum antibody titers, and absence of residual larval or cyst wall tissue render multifocal calcific involution of that parasite unprovable although still plausible. We also raise the possibility of a blood-brain barrier derangement and/or a metabolic disorder as an alternative etiology. Whether this case of MCAPNON shares the same pathogenesis as the usual solitary CAPNON is unclear.

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Section: Introductionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Multiple calcifying pseudoneoplasms of the neuraxis (MCAPNON): Distinct entity, CAPNON variant, or old neurocysticercosis?

Abdaljaleel

Mazumder

et al. 2016

Neuropathology

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“…Calcifying pseudoneoplasms of the neuraxis (CAPNON) are extremely rare fibro-osseous lesions that can be extra- or intra-axial. Histologically, these benign lesions are composed of a pathognomonic chondromyxoid matrix in an amorphous or nodular pattern as well as palisading spindle or epithelioid cells and varying proportions of fibrous stroma [24–26]. When present in the skull base, they are known to symptomatically encase cranial nerves.…”

Section: Introductionmentioning

confidence: 99%

Brain stones revisited—between a rock and a hard place

et al. 2013

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Objectives and methodsLarge intracranial calcifications are occasionally encountered in routine computed tomography (CT) scans of the brain. These calcifications, also known as “brain stones”, can be classified according to location and aetiology. Combining imaging findings with relevant clinical history and physical examination can help narrow down the differential diagnosis and may allow confident diagnosis in certain situations.ResultsThis article provides a pictorial review illustrating various clinical entities resulting in brain stones.DiscussionBased on location, brain stones can be classified as extra- or intra-axial. Extra-axial brain stones comprise tumours and exaggerated physiological calcifications. Intra-axial brain stones can further be classified according to aetiology, namely neoplastic, vascular, infectious, congenital and endocrine/metabolic. Imaging findings combined with essential clinical information can help in narrowing the differential diagnosis, determining disease state and evaluating effect of therapy.Teaching Points• Based on location, brain stones can be either extra- or intra-axial.• Extra-axial brain stones comprise tumours and exaggerated physiological calcifications.• Intra-axial aetiologies include neoplastic, vascular, infectious, congenital and endocrine/metabolic.• CT scan is the mainstay in identifying and characterising brain stones.• Certain MRI sequences (gradient echo T2* and susceptibility-weighted imaging) are considered adjunctive.

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“…Calcified, fibro-osseous lesions known as calcifying pseudoneoplasms of the neuraxis, cerebral calculi, or brain stones are extremely rare and are usually seen at the cranial base, commonly adjacent to the dura mater or the arachnoid 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29. However, they can occur anywhere within the neuraxis 2,3,5.…”

Section: Discussionmentioning

confidence: 99%

“…The patients with intracranial type most commonly presented with seizure (31.6%) followed by headache (13.2%) and cerebellar sign (5.3%) 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23. Three patients (8.1%) were found incidentally, and seven cases (18.9%) were autopsy findings.…”

Section: Discussionmentioning

confidence: 99%

Calcifying Pseudoneoplasms of the Skull Base Presenting with Cranial Neuropathies: Case Report and Literature Review

et al. 2012

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Objectives We report our institutional experience with calcifying pseudoneoplasms of the skull base that presented with cranial neuropathies. These lesions are also known as fibro-osseous lesions, cerebral calculi, or brain stones.Results One patient presented with facial numbness and retro-orbital pain secondary to compression of the maxillary branch of the trigeminal nerve at the anterior portion of the infratemporal fossa. The other patient presented with occipital headaches and hypoglossal nerve palsy. This patient was found to have a calcified lesion in the posterior fossa, which eroded the left occipital condyle.Conclusion Calcifying pseudoneoplasms are benign, slow-growing masses that are apparently cured by gross total resection. Even with incomplete tumor resection, the prognosis is considered to be favorable. We advocate a minimally invasive surgical resection of such tumors involving the cranial nerves.

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Cerebral calculi in the temporal horn of the lateral ventricle: report of an unusual case

Cited by 15 publications

References 3 publications

Multiple calcifying pseudoneoplasms of the neuraxis (MCAPNON): Distinct entity, CAPNON variant, or old neurocysticercosis?

Multiple calcifying pseudoneoplasms of the neuraxis (MCAPNON): Distinct entity, CAPNON variant, or old neurocysticercosis?

Brain stones revisited—between a rock and a hard place

Calcifying Pseudoneoplasms of the Skull Base Presenting with Cranial Neuropathies: Case Report and Literature Review

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