Cerebral blood flow in schizophrenia

Dousse, M.; Mamo, H; Ponsin, J. C.; Dinh, Yves-Roger Tran

doi:10.1016/0014-4886(88)90204-x

Cited by 21 publications

(11 citation statements)

References 28 publications

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“…Only in the intermediate situation where CBF difference is small but SNR is relative high, the rCBF shows a clear advantage. Interestingly, most of neuropsychiatric studies fall into this range (CBF difference between patient and control group is around 10–20%) [31–34]. The gray matter SNR in our experimental data was around 4.1 on a single voxel level.…”

Section: Discussionmentioning

confidence: 64%

“…However, questions remained as to whether ASL MRI can detect small CBF differences on the order of 10%, which is the typical range of CBF deficit occurring in many psychiatric and neurological disorders [31–34]. The present study provides a systematic investigation into the detection power of ASL and the optimal strategies for data analysis.…”

Section: Discussionmentioning

confidence: 97%

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On the sensitivity of ASL MRI in detecting regional differences in cerebral blood flow

Aslan

2010

Magnetic Resonance Imaging

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Arterial-spin-labeling (ASL) MRI provides a non-invasive tool to measure cerebral blood flow (CBF) and is increasingly used as a surrogate for baseline neural activity. However, the power of ASL MRI in detecting CBF differences between patient and control subjects is hampered by inter-subject variations in global CBF, which are associated with non-neural factors and may contribute to the noise in the across-group comparison. Here, we investigated the sensitivity of this technique and proposed a normalization strategy to better detect such a difference. A “model” situation was employed in which two visual stimuli (i.e. cross fixation and flashing checkerboard) were presented to two groups of subjects to mimic “control” and “patient” groups (N=7 for each group), respectively. It was found that absolute CBF (aCBF) in the occipital lobe in the checkerboard group was 26.0% greater compared to the fixation group, but the level of significance was modest (p=0.03). In contrast, when normalizing the CBF with whole-brain CBF or CBF in a reference region (termed relative CBF, rCBF), the statistical significance was improved considerably (p<0.003). For voxel based analysis, the rCBF indices correctly detected CBF differences in the occipital lobe in the across-group comparison, while aCBF failed to detect any significant cluster using the same statistical threshold. We also performed Monte Carlo simulation to confirm the experimental findings and found that the power improvement was most pronounced when SNR is moderate and the underlying CBF difference was small. The simulation also showed that, with the proposed normalization, a detection power of 80% can be achieved using a sample size of about 20. In summary, rCBF is a more sensitive index to detect small differences in CBF, rather than the much-sought-after aCBF, since it reduces data noise caused by inter-subject variations in global CBF.

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Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 97%

On the sensitivity of ASL MRI in detecting regional differences in cerebral blood flow

Aslan

2010

Magnetic Resonance Imaging

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“…Twenty‐nine studies (9, 12, 13, 16, 17, 31–54) provided global or hemisphere data (in which case left and right values were averaged). The pooled effect size for these was −0.27 (CI −0.39 to −0.15) with the negative sign indicating reduced flow/metabolism in schizophrenia (see Table 1).…”

Section: Whole Brain Blood Flow/metabolismmentioning

confidence: 99%

“…Forty‐seven studies reported values for relative frontal blood flow/metabolism (10–12, 14, 32, 33, 35, 40–43, 47, 50–55, 57, 58–86). The pooled effect size for these was −0.24 (CI −0.34 to −0.15).…”

Section: Resting Hypofrontalitymentioning

confidence: 99%

Hypofrontality in schizophrenia: a meta‐analysis of functional imaging studies

Hill

Mann

Laws

et al. 2004

Acta Psychiatr Scand

293

162

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“…The experience of visual hallucinations in a young schizophrenic patient was associated with reduced region al cerebral blood flow in temporo-occipital cortex [19] and an 81-year-old patient with features of the Charles Bonnet syndrome had reduced blood flow in the left occi pital region [20]. However, visual hallucinations in a patient who had suffered a left-sided stroke were associat ed with a bilaterally increased perfusion of the parietal and occipital lobes which returned to normal with suc cessful drug treatment of the hallucinations [21] and in a report of regional cerebral blood flow in 2 cases of Alz heimer's disease who experienced Lilliputian hallucina tions [22], 1 patient had an increased flow to his left tem poro-occipital association cortex which was thought to be related to hallucinosis.…”

Section: Functional Brain Im Aging Studies Of Visual Hallucinationsmentioning

confidence: 99%

Seeing Visual Hallucinations with Functional Magnetic Resonance Imaging

Howard

David

Woodruff³

et al. 1997

Dement Geriatr Cogn Disord

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We have used blood oxygenation level dependent imaging with functional magnetic resonance imaging (fMRI) to investigate the visual cortex response to photic stimulation during and in the absence of continuous visual hallucinations. A patient with cortical Lewy body dementia who experienced persistent and vivid complex hallucinations underwent fMRI on and off treatment with risperidone. When he was not hallucinating, photic stimulation produced a normal bilateral activation in striate cortex. During hallucinations, very limited activation in striate cortex could be induced. We interpret this result as indicating that at least part of the activity in the brain responsible for the experience of visual hallucinations is located in the primary visual cortex.

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Cerebral blood flow in schizophrenia

Cited by 21 publications

References 28 publications

On the sensitivity of ASL MRI in detecting regional differences in cerebral blood flow

On the sensitivity of ASL MRI in detecting regional differences in cerebral blood flow

Hypofrontality in schizophrenia: a meta‐analysis of functional imaging studies

Seeing Visual Hallucinations with Functional Magnetic Resonance Imaging

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