Cerebral Blood Flow in Primates Is Increased by Isoflurane over Time and Is Decreased by Nitric Oxide Synthase Inhibition

McPherson, Robert W.; Kirsch, Jeffrey R.; Tobin, Joseph R.; Ghaly, Ramsis F.; Traystman, Richard J.

doi:10.1097/00000542-199406000-00020

Cited by 45 publications

(24 citation statements)

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“…In particular, increased CBF was seen in the forebrain and hindbrain of cynomolgus monkeys with 1 MAC isoflurane for 4 h reported by McPherson et al (1994), different from the present findings. By comparing the experimental methods and materials between these primate and adult studies, such differences in the CBF findings are very likely due to the different experimental setting and procedures.…”

Section: Long-duration Effect Of Isoflurane On Cbfcontrasting

confidence: 99%

“…Isoflurane has strong dose-dependent effects on CBF as demonstrated in prior studies of anesthetized macaques or baboons (Li et al, 2013(Li et al, , 2014Van Aken et al, 1986). The duration effects of isoflurane on CBF have also been previously examined in anesthetized dogs (McPherson and Traystman, 1988) and goats (Albrecht et al, 1983), and monkeys (McPherson et al, 1994), but the conclusions remain controversial.…”

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Effects of Long-Duration Administration of 1% Isoflurane on Resting Cerebral Blood Flow and Default Mode Network in Macaque Monkeys

Zhang

2017

Brain Connectivity

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Isoflurane is an inhalational anesthetic that is widely used in medical procedures or biomedical research. The duration of anesthesia administration varies from minutes to hours. It is known that isoflurane has dosedependent effects on brain functionality and physiology, and long-duration anesthesia administration could cause neurocognitive decline in animals and humans. However, the duration effect of isoflurane on the brain physiology and functionality still remains poorly understood. In the present study, cerebral blood flow (CBF) and functional connectivity of adult rhesus monkeys (maintained with 1% isoflurane for 4 h) were examined by using magnetic resonance imaging. The results demonstrate that long-duration isoflurane exposure could result in CBF reduction in most brain areas and functional connectivity decrease in the dominant default-mode network. This study reveals the anesthetic duration effects in the central nervous system of anesthetized subjects and suggests that such duration effects should be considered in examining the brain function of anesthetized animals or humans with contemporary neuroimaging approaches.

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Section: Long-duration Effect Of Isoflurane On Cbfcontrasting

confidence: 99%

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confidence: 99%

Effects of Long-Duration Administration of 1% Isoflurane on Resting Cerebral Blood Flow and Default Mode Network in Macaque Monkeys

Zhang

2017

Brain Connectivity

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“…Most regions increased 0.02-0.133 ml/min/ml (average change 11.2%), but parietal and occipital cortex remained at the same level. These increases in K 1 are consistent with the work of Carson et al (1998) and most likely reflects time-related CBF increases associated with isoflurane administration (McPherson et al, 1994). These small increases in K 1 measures indicate that any procaine-induced flow increases may be slightly overestimated.…”

Section: Control Valuessupporting

confidence: 77%

A Potential Cholinergic Mechanism of Procaine's Limbic Activation

Benson

Carson

Kiesewetter

et al. 2004

Neuropsychopharmacol

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The local anesthetic procaine, when administered to humans intravenously (i.v.), yields brief intense emotional and sensory experiences, and concomitant increases in anterior paralimbic cerebral blood flow, as measured by positron emission tomography (PET). Procaine's high muscarinic affinity, together with the distribution of muscarinic receptors that overlaps with brain regions activated by procaine, suggests a muscarinic contribution to procaine's emotional and sensory effects. This study evaluates the effects of procaine on cerebral muscarinic cholinergic receptors in the anesthetized rhesus monkey. Whole brain and regional muscarinic receptor binding was measured before and after procaine administration on the same day in three anesthetized rhesus monkeys with PET and the radiotracer 3-(3-(3[ 18 F]fluoropropylthio)-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-methylpyridine ([ 18 F]FP-TZTP), a cholinergic ligand that has preferential binding to muscarinic (M 2 ) receptors. On separate days each animal received six different doses of i.v. procaine in a randomized fashion. Procaine blocked up to B90% of [ 18 F]FP-TZTP specific binding globally in a dose-related manner. There were no regional differences in procaine's inhibitory concentration for 50% blockade (IC 50 ) for [ 18 F]FP-TZTP. Tracer delivery, which was highly correlated to cerebral blood flow in previous monkey studies, was significantly increased at all doses of procaine with the greatest increases occurring near procaine's IC 50 for average cortex. Furthermore, anterior limbic regions showed greater increases in tracer delivery than nonlimbic regions. Procaine has high affinity to muscarinic M 2 receptors in vivo in the rhesus monkey. This, as well as a preferential increase of tracer delivery to paralimbic regions, suggests that action at these receptors could contribute to i.v. procaine's emotional and sensory effects in man. These findings are consistent with other evidence of cholinergic modulation of mood and emotion.

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“…Since statistically significant changes over time in baseline CBF during inhalational anaesthesia may occur over a period of several hours (15,16), the order of the three drugs in each experiment was randomized.…”

Section: Experimental Designmentioning

confidence: 99%

Desflurane results in higher cerebral blood flow than sevoflurane or isoflurane at hypocapnia in pigs

Holmström¹,

Rosén

Åkeson³

2004

Acta Anaesthesiol Scand

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Desflurane results in higher cerebral blood flow than sevoflurane or isoflurane at hypocapnia in pigs. Link to publication Citation for published version (APA): Holmström, A., Rosén, I., & Åkeson, J. (2004). Desflurane results in higher cerebral blood flow than sevoflurane or isoflurane at hypocapnia in pigs. Acta Anaesthesiologica Scandinavica, 48(4), 400-404. DOI: 10.1111400-404. DOI: 10. /j.0001-5172.2004 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Background: In clinical neuroanaesthesia, the increase in cerebral blood flow (CBF) and intracranial pressure caused by the cerebral vasodilative effects of an inhalational anaesthetic agent is counteracted by the cerebral vasoconstriction induced by hypocapnia. Desflurane and sevoflurane may have advantages over the more traditionally used isoflurane in neuroanaesthesia but their dose-dependent vasodilative effects at hypocapnia have not been compared in the same model using truly equipotent minimal alveolar concentrations (MACs). Method: Desflurane, sevoflurane and isoflurane were administered in a randomized order to six pigs at 0.5 and 1.0 MAC. The intra-arterial xenon clearance technique was used to calculate CBF. Blood pressure was invasively monitored. Cerebral and systemic physiological variables were recorded first at normocapnia (PaCO 2 5.6 kPa) and then at hypocapnia (PaCO 2 3.5 kPa). Electroencephalographic (EEG) activity was continuously recorded. Results: None of the three agents abolished cerebrovascular reactivity to hyperventilation, and at 0.5 MAC all had similar

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Cerebral Blood Flow in Primates Is Increased by Isoflurane over Time and Is Decreased by Nitric Oxide Synthase Inhibition

Cited by 45 publications

References 0 publications

Effects of Long-Duration Administration of 1% Isoflurane on Resting Cerebral Blood Flow and Default Mode Network in Macaque Monkeys

Effects of Long-Duration Administration of 1% Isoflurane on Resting Cerebral Blood Flow and Default Mode Network in Macaque Monkeys

A Potential Cholinergic Mechanism of Procaine's Limbic Activation

Desflurane results in higher cerebral blood flow than sevoflurane or isoflurane at hypocapnia in pigs

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