Cerebral Blood Flow in Parkinson’s Disease, Dementia with Lewy Bodies, and Alzheimer’s Disease according to Three-Dimensional Stereotactic Surface Projection Imaging

Kasama, Shuhei; Tachibana, Hideki; Kawabata, Keita; Yoshikawa, Hiroaki

doi:10.1159/000084551

Cited by 35 publications

(22 citation statements)

References 84 publications

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“…As in our investigation, combinations of antioxidants have been shown to be more effective than single agents in at least some cases [43]. Vasoregulators are also clearly of potential benefit given observations of reduced cortical blood flow in both Alzheimer's and Parkinson's disease [114][115][116][117][118]. This similarity of free radical production and reduced blood flow in neurodegenerative processes and NIHL, and the demonstrated efficacy of antioxidants plus magnesium in reducing sensory cell death and neurodegeneration in the cochlea, provides a compelling rationale for study of combinations of antioxidants, with and without magnesium, to ameliorate neurodegeneration from other stresses and disease processes, at other sites of the nervous system, of more heterogeneous origins, such as Alzheimer's disease, Parkinson's disease, and stroke.…”

supporting

confidence: 51%

Free radical scavengers vitamins A, C, and E plus magnesium reduce noise trauma

Prell

Hughes

Miller

2007

Free Radical Biology and Medicine

198

188

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Free radical formation in the cochlea plays a key role in the development of noise-induced hearing loss (NIHL). The amount, distribution, and time course of free radical formation have been defined, including a clinically significant formation of both reactive oxygen species and reactive nitrogen species 7-10 days following noise exposure. Reduction in cochlear blood flow as a result of free radical formation has also been described. Here we report that the antioxidant agents, vitamins A, C, and E, act in synergy with magnesium to effectively prevent noise-induced trauma. Neither the antioxidant agents nor magnesium reliably reduced NIHL or sensory cell death with the doses we used when these agents were delivered alone. In combination, however, they were highly effective in reducing both hearing loss and cell death even with treatment initiated just one hour prior to noise exposure. This study supports roles for both free radical formation and noise-induced vasoconstriction in the onset and progression of NIHL. Identification of this safe and effective antioxidant intervention that attenuates NIHL provides a compelling rationale for human trials in which free radical scavengers are used to eliminate this single major cause of acquired hearing loss. Keywords cochlea; free radical; noise; hearing; antioxidant; vasodilation Mechanical destruction of cells in the organ of Corti was once assumed to be the primary cause of noise-induced hearing loss (NIHL) [1][2][3][4][5][6][7][8], with perhaps some effect of reduced blood flow to the inner ear [9][10][11][12][13][14][15][16][17][18]. We now know that another key factor is intense metabolic activity that results in production of excess free radicals [19][20][21][22][23] and lipid peroxidation products [24]. Noise-induced production of reactive oxygen species (ROS) in the cochlea has now been well characterized, and several recent reviews are available [25][26][27]. Mitochodrial dysfunction and ROS production have been implicated in numerous neurodegenerative syndromes and diseases [28-34, see 35,36]. The use of antioxidant agents holds significant therapeutic promise for many neurodegenerative processes [32,33,[37][38][39][40][41][42], and there is some suggestion that Correspondence to: C. G. Le Prell, Kresge Hearing Research Institute, University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109-0506, USA. Tel: +1-734-763-5104; fax +1-734-764-0014. E-mail address: colleeng@umich.edu. Disclosure. Dr. Miller is a founding member and Chairman of the Board of Directors at OtoMedicine, Inc., a company that has an option to license the intellectual property described in this report. Dr. Le Prell is a paid consultant to OtoMedicine, Inc. Drs. Miller and Le Prell have disclosed these relationships to the Medical School Conflict of Interest Board at the University of Michigan; conflict management plans including semi-annual review by the Board are in place.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publicatio...

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supporting

confidence: 51%

Free radical scavengers vitamins A, C, and E plus magnesium reduce noise trauma

Prell

Hughes

Miller

2007

Free Radical Biology and Medicine

198

188

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“…One theme of this research has been to identify diagnostic biomarkers through neuroimaging that enable early detection of the disease, even before the full clinical symptoms of AD have become manifest. Neuroimaging has identified a wide array of biomarkers that can differentiate AD patients from healthy control subjects such as volume loss measured with morphometry (e.g., (Bozzali et al, 2006;Chetelat et al, 2005;Teipel et al, 2005;Thomann et al, 2006) cerebral blood flow (e.g., (Kasama et al, 2005;Nakano et al, 2006;Trollor et al, 2005)), glucose metabolism ( (Burdette et al, 1996;Chetelat et al, 2003b;Foster et al, 2007;Herholz et al, 2002;Higdon et al, 2004)) and betaamyloid deposition (e.g., (Engler et al, 2006;Nichols et al, 2006)). Often these analyses target specific locations (entorhinal cortex, hippocampus, prefrontal cortex, amygdala etc.…”

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confidence: 99%

Multivariate and univariate neuroimaging biomarkers of Alzheimer's disease

et al. 2008

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We performed univariate and multivariate discriminant analysis of FDG-PET scans to evaluate their ability to identify Alzheimer's disease (AD). FDG-PET scans came from two sources: 17 AD patients and 33 healthy elderly controls were scanned at the University of Michigan; 102 early AD patients and 20 healthy elderly controls were scanned at the Technical University of Munich, Germany. We selected a derivation sample of 20 AD patients and 20 healthy controls matched on age with the remainder divided into 5 replication samples. The sensitivity and specificity of diagnostic ADmarkers and threshold criteria from the derivation sample were determined in the replication samples. Although both univariate and multivariate analyses produced markers with high classification accuracy in the derivation sample, the multivariate marker's diagnostic performance in the replication samples was superior. Further, supplementary analysis showed its performance to be unaffected by the loss of key regions. Multivariate measures of AD utilize the covariance structure of imaging data and provide complementary, clinically relevant information that may be superior to univariate measures.

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“…The few reports directly comparing perfusion profiles in patients with DLB and PDD using single-photon emission computed tomography (SPECT) have shown that DLB and PDD produce similar perfusion deficits in the frontal and lateral parieto-occipital regions [6,7]. However, images obtained with positron emission tomography (PET) have much greater spatial resolution and attenuation correction than those obtained with SPECT.…”

mentioning

confidence: 99%

A comparison of cerebral glucose metabolism in Parkinson's disease, Parkinson's disease dementia and dementia with Lewy bodies

Yong

Yoon

et al. 2007

Euro J of Neurology

130

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Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) share many similar aspects, and making a clinical diagnosis of one disorder over the other relies heavily on an arbitrary criterion, so-called 1-year rule. This study was designed to search for any difference of metabolic patterns in these two disorders using F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) images. We enrolled 16 patients with PD, 13 patients with PDD, and seven patients with DLB. FDG PET was performed, and images were reconstructed by iterative reconstruction using the computed tomography (CT) images, and were normalized to a standard template. Statistical comparison between groups were performed on a voxel-by-voxel basis using t-statistics (two-sample t-test). Compared with the patients with PD, both PDD and DLB patients showed similar patterns of decreased metabolism in bilateral inferior and medial frontal lobes, and right parietal lobe (P uncorrected < 0.001). In a direct comparison, DLB patients had significant metabolic decrease (p uncorrected < 0.005) in the anterior cingulate compared with those with PDD. These findings support the concept that PDD and DLB have similar underlying neurobiological characteristics, and that they can be regarded as a spectrum of Lewy body disorders.The current diagnostic consensus for differentiating dementia with Lewy bodies (DLB) from Parkinson's disease dementia (PDD) relies heavily on an arbitrary criterion, the so-called 1-year rule, in which the clinical diagnosis depends on the duration of parkinsonism prior to onset of dementia [1]. However, DLB and PDD share many clinical and neurobiological similarities, including similar motor effects, neuropsychological profiles, and neurochemical and neuropathological findings [2].Previous studies about cerebral metabolic profiles, which are helpful in understanding the underlying neurobiological basis have separately focused on patients with either DLB or PDD and have compared these patients with those suffering from Alzheimer's disease [3][4][5]. The few reports directly comparing perfusion profiles in patients with DLB and PDD using single-photon emission computed tomography (SPECT) have shown that DLB and PDD produce similar perfusion deficits in the frontal and lateral parieto-occipital regions [6,7]. However, images obtained with positron emission tomography (PET) have much greater spatial resolution and attenuation correction than those obtained with SPECT. A study comparing PET and SPECT images in patients with DLB has verified the superiority of PET in demonstrating regional effects on cerebral metabolism in DLB [8]. In the present study, we compared cerebral glucose metabolism in patients with DLB, PDD and PD, using PET to search for any differences in the metabolic patterns produced by these diseases. Patients and methods SubjectsWe enrolled 36 patients evaluated at Ajou University Hospital: seven patients with DLB, 13 with PDD and 16 with PD. Clinical diagnosis were made according to the consensus criteria for DLB...

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Cerebral Blood Flow in Parkinson’s Disease, Dementia with Lewy Bodies, and Alzheimer’s Disease according to Three-Dimensional Stereotactic Surface Projection Imaging

Cited by 35 publications

References 84 publications

Free radical scavengers vitamins A, C, and E plus magnesium reduce noise trauma

Free radical scavengers vitamins A, C, and E plus magnesium reduce noise trauma

Multivariate and univariate neuroimaging biomarkers of Alzheimer's disease

A comparison of cerebral glucose metabolism in Parkinson's disease, Parkinson's disease dementia and dementia with Lewy bodies

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