Cerebral blood flow in chronic symptomatic mild traumatic brain injury

Bonne, Omer; Gilboa, Asaf; Louzoun, Yoram; Kempf-Sherf, Orli; Katz, Maor; Fishman, Yeri; Ben-Nahum, Zila; Krausz, Yodphat; Bocher, Moshe; Lester, Hava; Chisin, Roland; Lerer, Bernard

doi:10.1016/s0925-4927(03)00109-4

Cited by 127 publications

(82 citation statements)

References 24 publications

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“…3). In accordance with the view that perfusion compromise is linked to functional deficits (Bonne et al, 2003;Immonem et al, 2010), we found that the reduction of hypoperfusion area was associated with the augmentation of functional recovery as evaluated by mNSS (compare Fig. 3G with Fig.…”

Section: Discussionsupporting

confidence: 89%

“…distinct differences in pathologies between stroke and trauma (Cunningham et al, 2005). Our longitudinal observation confirmed the previous experimental and clinical reports that TBI-induced hypoperfusion occurred at the lesion site and also in distant non-lesion regions (Bonne et al, 2003;Hofman et al, 2001;Pasco et al, 2007). Compared to a cystic lesion with a remarkable and permanent CBF disturbance, the transient reduction in CBF in these regions after TBI could ultimately diminish at a later chronic stage, such as found 1 year post-injury for rat (Kochanek et al, 2002), due to vascular remodeling of the brain.…”

Section: Discussionsupporting

confidence: 88%

“…Extensive axonal degeneration (Bigler, 1987;Ding et al, 2008;Mamere et al, 2009) and generalized cerebral atrophy (MacKenzie et al, 2002;Sidaros et al, 2009;Trivedi et al, 2007) associated with poor functional outcomes are the common sequelae. TBI-induced hypoperfusion, which could occur beyond the site of primary injury (Bonne et al, 2003;Hofman et al, 2001;Pasco et al, 2007), aggravates this trauma-triggered brain damage. To date, however, the management of patients with TBI has generally concentrated on the prevention or amelioration of such devastating secondary Although mechanisms responsible for the observed therapeutic potential of MSCs remain to be explored, it is suggested that the beneficial effects are owed to the ability of MSCs to secrete an array of cytokines and trophic factors that activate endogenous restorative and regenerative processes, e.g., angiogenesis, synaptogenesis, gliogenesis, and neurogenesis (Chopp and Li, 2006;Mahmood et al, 2004aMahmood et al, , 2004b.…”

Section: Introductionmentioning

confidence: 99%

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Transplantation of Marrow Stromal Cells Restores Cerebral Blood Flow and Reduces Cerebral Atrophy in Rats with Traumatic Brain Injury: In vivo MRI Study

Jiang

et al. 2011

Journal of Neurotrauma

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Cell therapy promotes brain remodeling and improves functional recovery after various central nervous system disorders, including traumatic brain injury (TBI). We tested the hypothesis that treatment of TBI with intravenous administration of human marrow stromal cells (hMSCs) provides therapeutic benefit in modifying hemodynamic and structural abnormalities, which are detectable by in vivo MRI. hMSCs were labeled with superparamagnetic iron oxide (SPIO) nanoparticles. Male Wistar rats (300-350 g, n = 18) subjected to controlled cortical impact TBI were intravenously injected with 1 mL of saline (n = 9) or hMSCs in suspension (n = 9, approximately 3 · 10 6 SPIO-labeled hMSCs) 5 days post-TBI. In vivo MRI measurements consisting of cerebral blood flow (CBF), T2-weighted imaging, and 3D gradient echo imaging were performed for all animals 2 days post-TBI and weekly for 6 weeks. Functional outcome was evaluated with modified neurological severity score and Morris water maze test. Cell engraftment was detected in vivo by 3D MRI and confirmed by double staining. Ventricle and lesion volumetric alterations were measured using T2 maps, and hemodynamic abnormality was tracked by MRI CBF measurements. Our data demonstrate that treatment with hMSCs following TBI diminishes hemodynamic abnormalities by early restoration and preservation of CBF in the brain regions adjacent to and remote from the impact site, and reduces generalized cerebral atrophy, all of which may contribute to the observed improvement of functional outcome.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

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Transplantation of Marrow Stromal Cells Restores Cerebral Blood Flow and Reduces Cerebral Atrophy in Rats with Traumatic Brain Injury: In vivo MRI Study

Jiang

et al. 2011

Journal of Neurotrauma

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“…Particularly, decreased CBF acutely after impact has been documented (Kelly et al, 1996;Kelly et al, 1997;Martin et al, 1997). Long term deviations from the normal CBF level have been depicted, and even patients with symptomatic mild traumatic brain injury but without any other abnormal MRI findings have shown persistent regional hypoperfusion (Bonne et al, 2003). Fig.…”

Section: From Morphology To Function -Hemodynamic Alterations After Tbimentioning

confidence: 95%

MRI Characterization of Progressive Brain Alterations After Experimental Traumatic Brain Injury: Region Specific Tissue Damage, Hemodynamic Changes and Axonal Injury

Immonen¹,

Hayward²

2012

Brain Injury - Pathogenesis, Monitoring, Recovery and Management

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“…CBF abnormalities are commonly seen in mild TBI patients with chronic symptoms, even if no structural damage is apparent. 123 Often the size of the lesion on SPECT exceeds the size of the lesion on CT or MRI.…”

Section: Prognosis and Spectmentioning

confidence: 99%

Neuroimaging in traumatic brain imaging

Lee

Newberg

2005

Neurotherapeutics

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Summary: Traumatic brain injury (TBI) is a common and potentially devastating clinical problem. Because prompt proper management of TBI sequelae can significantly alter the clinical course especially within 48 h of the injury, neuroimaging techniques have become an important part of the diagnostic work up of such patients. In the acute setting, these imaging studies can determine the presence and extent of injury and guide surgical planning and minimally invasive interventions. Neuroimaging also can be important in the chronic therapy of TBI, identifying chronic sequelae, determining prognosis, and guiding rehabilitation.

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Cerebral blood flow in chronic symptomatic mild traumatic brain injury

Cited by 127 publications

References 24 publications

Transplantation of Marrow Stromal Cells Restores Cerebral Blood Flow and Reduces Cerebral Atrophy in Rats with Traumatic Brain Injury: In vivo MRI Study

Transplantation of Marrow Stromal Cells Restores Cerebral Blood Flow and Reduces Cerebral Atrophy in Rats with Traumatic Brain Injury: In vivo MRI Study

MRI Characterization of Progressive Brain Alterations After Experimental Traumatic Brain Injury: Region Specific Tissue Damage, Hemodynamic Changes and Axonal Injury

Neuroimaging in traumatic brain imaging

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