Cerebral blood flow changes in benign aging and cerebrovascular disease

Shaw, Terry; Mortel, Karl F.; Meyer, John Stirling; Rogers, Robert L.; Hardenberg, Jeffery; Cutaia, Michael M.

doi:10.1212/wnl.34.7.855

Cited by 297 publications

(176 citation statements)

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“…Repeated measurements in a subgroup of 20 subjects confirmed a high reproducibility. We did not find a global decrease of CBF corr which agrees with some studies (6,21) but contradicts several earlier studies reporting a global decline in CBF with healthy ageing (4,10,12). More recent studies claim that an apparent reduction in CBF results from reduced GM volume rather than reduced perfusion (7,8,22).…”

Section: Discussionsupporting

confidence: 82%

“…However, its role in healthy ageing is not well understood. Early investigations of age-related CBF changes using positron emission tomography (PET) or single photon emission computed tomography (SPECT) found a general decline of CBF in whole brain or grey matter (GM) (3,4). More recent PET-based studies explored CBF in selected regions of interest (5,6) and stressed the confounding influence of partial volume effects (7,8) due to atrophy in the ageing brain.…”

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confidence: 99%

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Age‐related cerebral perfusion changes in the parietal and temporal lobes measured by pulsed arterial spin labeling

Preibisch¹,

Sorg²,

Förschler³

et al. 2011

Magnetic Resonance Imaging

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Purpose: To investigate age-related regional perfusion changes focused on the medial temporal lobes and related parietal areas using a pulsed arterial spin labeling technique. Materials and Methods:Resting cerebral blood flow (CBF) maps were obtained from 44 healthy volunteers (18 male, 26 female; age range, 19 to 79 years) using a pulsed arterial spin labeling (PASL) MRI technique at 3 Tesla focused on the parietal and temporal lobes. Repeated measurements were performed in 20 subjects to assure the reliability and reproducibility of the applied PASL technique.Results: Focal age-related CBF decreases were detected in the parietal cortex, cuneus and caudate, whereas increases were seen in the lateral and medial temporal lobe such as hippocampus, the calcarine gyrus and the thalamus. Moreover, repeated measurements demonstrated a high reliability and reproducibility of the applied PASL technique.Conclusion: Data provide evidence for regionally dissociated patterns of perfusion increases and decreases during ageing in the temporal and parietal lobes.

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Section: Discussionsupporting

confidence: 82%

mentioning

confidence: 99%

Age‐related cerebral perfusion changes in the parietal and temporal lobes measured by pulsed arterial spin labeling

Preibisch¹,

Sorg²,

Förschler³

et al. 2011

Magnetic Resonance Imaging

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“…As the metabolism of the neurons that remain is also reduced, a lower CBF is sufficient to maintain neuronal viability (Shaw et al, 1984). However, if the decrease in CBF was a consequence of brain atrophy, we would have expected to find a relation between global brain atrophy and CBF, because the regional CBF in the cortical gray matter is two to three times higher than in the cerebral white matter.…”

Section: Discussionmentioning

confidence: 99%

Total Cerebral Blood Flow, White Matter Lesions and Brain Atrophy: The SMART-MR Study

Appelman

Graaf

Vincken

et al. 2007

J Cereb Blood Flow Metab

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We investigated whether total cerebral blood flow (CBF) was associated with brain atrophy, and whether this relation was modified by white matter lesions (WML). Within the Second Manifestations of ARTerial disease-magnetic resonance (SMART-MR) study, a prospective cohort study among patients with arterial disease, cross-sectional analyses were performed in 828 patients (mean age 58 610 years, 81% male) with quantitative flow, atrophy, and WML measurements on magnetic resonance imaging (MRI). Total CBF was measured with MR angiography and was expressed per 100 mL brain volume. Total brain volume and ventricular volume were divided by intracranial volume to obtain brain parenchymal fraction (BPF) and ventricular fraction (VF). Lower BPF indicates more global brain atrophy, whereas higher VF indicates more subcortical brain atrophy. Mean CBF was 52.0610.2 mL/min per 100 mL, mean BPF was 79.262.9%, and mean VF was 2.0360.96%. Linear regression analyses showed that lower CBF was associated with more subcortical brain atrophy, after adjusting for age, sex, vascular risk factors, intima-media thickness, and lacunar infarcts, but only in patients with moderate to severe WML (upper quartile of WML): Change in VF per s.d. decrease in CBF 0.18%, 95% CI: 0.02 to 0.34%. Our findings suggest that cerebral hypoperfusion in the presence of WML may be associated with subcortical brain atrophy.

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“…e.g., Grady et al, 1998;Raz et al, 1997;Salat, Kaye, & Janowsky, 1999;Shaw et al, 1984) and in neurochemical systems such as the dopamine (DA) system (e.g., Arnsten, Cai, Steere, & GoldmanRakic, 1995;Suhara et al, 1991;Volkow et al, 1998). However, despite accumulating evidence about these biological and cognitive changes, there is still little understanding of whether or how they are associated.…”

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confidence: 99%

Context processing in older adults: Evidence for a theory relating cognitive control to neurobiology in healthy aging.

Braver

Deanna²,

Keys³

et al. 2001

Journal of Experimental Psychology: General

425

440

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A theory of cognitive aging is presented in which healthy older adults are hypothesized to suffer from disturbances in the processing of context that impair cognitive control function across multiple domains, including attention, inhibition, and working memory. These cognitive disturbances are postulated to be directly related to age-related decline in the function of the dopamine (DA) system in the prefrontal cortex (PFC). A connectionist computational model is described that implements specific mechanisms for the role of DA and PFC in context processing. The behavioral predictions of the model were tested in a large sample of older (N = 81) and young (N = 175) adults performing variants of a simple cognitive control task that placed differential demands on context processing. Older adults exhibited both performance decrements and, counterintuitively, performance improvements that are in close agreement with model predictions.There are a number of cognitive and biological changes that appear to occur during healthy aging. At the cognitive level, these changes include declines in functions such as episodic and working memory, attention, and inhibition (e.g

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Cerebral blood flow changes in benign aging and cerebrovascular disease

Cited by 297 publications

References 0 publications

Age‐related cerebral perfusion changes in the parietal and temporal lobes measured by pulsed arterial spin labeling

Age‐related cerebral perfusion changes in the parietal and temporal lobes measured by pulsed arterial spin labeling

Total Cerebral Blood Flow, White Matter Lesions and Brain Atrophy: The SMART-MR Study

Context processing in older adults: Evidence for a theory relating cognitive control to neurobiology in healthy aging.

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