Cerebral blood flow and cerebrovascular CO
            <sub>2</sub>
            reactivity in stroke‐age normal controls

Davis, Stephen M.; Ackerman, Robert H.; Correia, John A.; Alpert, Nathaniel M.; Chang, Joshua; Buonanno, Ferdinando S.; Kelley, Roger E.; Rosner, Bernard; Taveras, Juan M.

doi:10.1212/wnl.33.4.391

Cited by 153 publications

(82 citation statements)

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“…Significantly higher CBF values in female subjects were also reported by Shaw et al (1984) and Gundling et al (1985). Their findings to gether with those of Davis et al (1983), who showed that the mean flow differences were present until the sixth decade, are in good agree ment with our data. Fairly consistent results thus indicate that women have a higher mean CBF level than do men.…”

Section: Discussionsupporting

confidence: 93%

See 1 more Smart Citation

Sex Differences in Regional Cerebral Blood Flow

Rodriguez¹,

Warkentin

Risberg

et al. 1988

J Cereb Blood Flow Metab

246

126

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Summary: Regional cerebral blood flow was measured by the 133-xenon inhalation method during resting in 38 healthy men and 38 healthy women matched pairwise for age in the range 18-72 years. The results showed 11 % higher global flow level in the women in all ages. A sim ilar and significant regression of flow by age was seen for both sexes. The regional flow distribution also showed some sex-related differences. Frontal regions showed an asymmetry in the men with higher values on the right

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Section: Discussionsupporting

confidence: 93%

“…( , 1987a) demonstrated significantly higher mean hemispheric blood flow levels in fe male compared with male subjects. Higher flow levels in women were also reported by Davis et al (1983), Shaw et al (1984), and Gundling et aI. (1985).…”

supporting

confidence: 58%

Sex Differences in Regional Cerebral Blood Flow

Rodriguez¹,

Warkentin

Risberg

et al. 1988

J Cereb Blood Flow Metab

246

126

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show abstract

“…Influence of age on cerebral blood flow and cerebrovascular reactivity at rest and during exercise Older individuals have been reported to have a maintained (Davis et al 1983;Ito et al 2002;Kastrup et al 1998;Schwertfeger et al 2006;Galvin et al 2010) and reduced (Reich and Rusinek 1989;Yamamoto et al 1980) hypercapnic cerebrovascular reactivity compared to younger individuals. The reasons for the discrepancy are likely to be multi-factorial and may include differences in CBF measurement technique (i.e.…”

Section: Discussionmentioning

confidence: 99%

“…The effect of healthy ageing on cerebrovascular CO2 reactivity is less clear, however. Hypercapnic reactivity has been found to be both lower (Reich and Rusinek 1989;Yamamoto et al 1980) and unchanged (Davis et al 1983;Ito et al 2002;Kastrup et al 1998;Schwertfeger et al 2006;Galvin et al 2010) with advancing age, while hypocapnic reactivity has been found to be elevated (Galvin et al 2010), unchanged (Ito et al 2002) and reduced (Yamaguchi et al 1979;Tsuda and Hartmann 1989). Differences in measurement technique, stimulus magnitude (i.e.…”

Section: Introductionmentioning

confidence: 99%

Cerebral blood flow and cerebrovascular reactivity at rest and during sub-maximal exercise: Effect of age and 12-week exercise training

Murrell

Cotter

Thomas

et al. 2012

AGE

165

180

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Chronic reductions in cerebral blood flow (CBF) and cerebrovascular reactivity to CO 2 are risk factors for cerebrovascular disease. Higher aerobic fitness is associated with higher CBF at any age; however, whether CBF or reactivity can be elevated following an exercise training intervention in healthy individuals is unknown. The aim of this study was to assess the effect of exercise training on CBF and cerebrovascular reactivity at rest and during exercise in young and older individuals. Ten young (23±5 years; body mass index ) previously sedentary individuals breathed 5 % CO 2 for 3 min at rest and during steady-state cycling exercise (30 and 70 % heart rate range (HRR)) prior to and following a 12-week aerobic exercise intervention. Effects of training on middle cerebral artery blood velocity (MCAv) at rest were unclear in both age groups. The absolute MCAv response to exercise was greater in the young (9 and 9 cm s −1 (30 and 70 % HRR, respectively) vs. 5 and 4 cm s −1 (older), P<0.05) and was similar following training. Cerebrovascular reactivity was elevated following the 12-week training at rest (2.87±0.76 vs. 2.54± 1.12 cm s −1 mm Hg −1 , P00.01) and during exercise, irrespective of age. The finding of a training-induced elevation in cerebrovascular reactivity provides further support for exercise as a preventative tool in cerebrovascular and neurological disease with ageing.

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“…4,15,17,[31][32][33] Previous studies of aging effects on cerebral CO2 reactivity often were conducted either during hypocapnia or hypercapnia separately. 8,9,20,28,29 Thus, findings of this study can be compared directly with those conducted under similar conditions. 8,9,20,28,29 Second, different from previous studies which have used prolonged rebreathing protocols (B5-7 minutes) to induce a wide range of changes in arterial CO2, a relatively short period of 3 minutes was used in this study to induce a moderate increase in EtCO2 and linear increases in CBFV to facilitate data analysis.…”

Section: Methodological Considerations and Study Limitationsmentioning

confidence: 95%

Cerebral Vasomotor Reactivity during Hypo- and Hypercapnia in Sedentary Elderly and Masters Athletes

Zhu

Tarumi

Tseng

et al. 2013

J Cereb Blood Flow Metab

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Physical activity may influence cerebrovascular function. The objective of this study was to determine the impact of life-long aerobic exercise training on cerebral vasomotor reactivity (CVMR) to changes in end-tidal CO2 (EtCO2) in older adults. Eleven sedentary young (SY, 27 ± 5 years), 10 sedentary elderly (SE, 72 ± 4 years), and 11 Masters athletes (MA, 72 ± 6 years) underwent the measurements of cerebral blood flow velocity (CBFV), arterial blood pressure, and EtCO2 during hypocapnic hyperventilation and hypercapnic rebreathing. Baseline CBFV was lower in SE and MA than in SY while no difference was observed between SE and MA. During hypocapnia, CVMR was lower in SE and MA compared with SY (1.87 ± 0.42 and 1.47 ± 0.21 vs. 2.18 ± 0.28 CBFV%/mm Hg, Po0.05) while being lowest in MA among all groups (Po0.05). In response to hypercapnia, SE and MA exhibited greater CVMR than SY (6.00 ± 0.94 and 6.67 ± 1.09 vs. 3.70 ± 1.08 CBFV1%/mm Hg, Po0.05) while no difference was observed between SE and MA. A negative linear correlation between hypo-and hypercapnic CVMR (R 2 ¼ 0.37, Po0.001) was observed across all groups. Advanced age was associated with lower resting CBFV and lower hypocapnic but greater hypercapnic CVMR. However, life-long aerobic exercise training appears to have minimal effects on these age-related differences in cerebral hemodynamics.

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Cerebral blood flow and cerebrovascular CO ₂ reactivity in stroke‐age normal controls

Cited by 153 publications

References 0 publications

Sex Differences in Regional Cerebral Blood Flow

Sex Differences in Regional Cerebral Blood Flow

Cerebral blood flow and cerebrovascular reactivity at rest and during sub-maximal exercise: Effect of age and 12-week exercise training

Cerebral Vasomotor Reactivity during Hypo- and Hypercapnia in Sedentary Elderly and Masters Athletes

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Cerebral blood flow and cerebrovascular CO 2 reactivity in stroke‐age normal controls

Cited by 153 publications

References 0 publications

Sex Differences in Regional Cerebral Blood Flow

Sex Differences in Regional Cerebral Blood Flow

Cerebral blood flow and cerebrovascular reactivity at rest and during sub-maximal exercise: Effect of age and 12-week exercise training

Cerebral Vasomotor Reactivity during Hypo- and Hypercapnia in Sedentary Elderly and Masters Athletes

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Cerebral blood flow and cerebrovascular CO ₂ reactivity in stroke‐age normal controls