Cerebral blood flow and cerebrovascular resistance across the adult lifespan: A multimodality approach

Tomoto, Tsubasa; Lu, Marilyn; Khan, Ayaz; Liu, Jie; Pasha, Evan; Tarumi, Takashi; Zhang, Rong

doi:10.1177/0271678x231153741

Cited by 10 publications

(29 citation statements)

References 63 publications

(175 reference statements)

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“…The scatter plot of the CBF ASL /CBF PC ratio with respect to mean flow velocity. males, 6,7,11,12,21 while other studies have found no sex-related differences. 22,23 Using the same cohort, the findings in this study also exhibited heterogeneity.…”

Section: F I G U R Ementioning

confidence: 60%

“…Understanding the differences or consistency between these modalities in CBF quantification is essential for interpreting data across different studies. However, one aspect often overlooked in these earlier comparisons is the inclusion of subjects across a wide age range, which can contribute to increased intersubject variability 6–8 . It is crucial to acknowledge that age plays a significant role in cerebral physiology, and flow impedance starts to increase after the age of 40 years 10 .…”

Section: Introductionmentioning

confidence: 99%

“…5 Given that measured CBF variability reflects intersubject differences and methodological biases, several studies have compared PC-MRI with ASL in the same cohort of subjects. [6][7][8][9] Understanding the differences or consistency between these modalities in CBF quantification is essential for interpreting data across different studies. However, one aspect often overlooked in these earlier comparisons is the inclusion of subjects across a wide age range, which can contribute to increased intersubject variability.…”

mentioning

confidence: 99%

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Range and variability of CBF in young adults: PC‐MRI and ASL studies

Su,

Peng

2023

Int J Imaging Syst Tech

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Several studies have compared phase contrast magnetic resonance imaging (PC‐MRI) with arterial spin labeling (ASL) in the same cohort of subjects. However, these earlier comparisons included subjects across a wide age range, which can contribute to increased intersubject variability. We compared the range and variability of CBF based on PC‐MRI and ASL in a group of young subjects. We also explored whether the comparison between PC‐MRI and ASL was dependent on sex. Thirty young subjects (17 females) were recruited in this study. The CBF from PC‐MRI (CBFPC) was calculated as the total blood flow normalized to brain parenchyma mass. The CBF from ASL (CBFASL) was quantified based on the perfusion kinetic model. The ratio between CBFASL and CBFPC was calculated. Females exhibited significantly higher CBF using both PC‐MRI (p < 0.05) and ASL (p < 0.005) compared with males. The disparity in CBF between sexes was more prominent in ASL measurements. A significant correlation was observed between CBFPC and CBFASL values (r = 0.47, p < 0.01), and CBFASL tended to be lower than CBFPC values (p < 0.001). This difference between CBFASL and CBFPC was more pronounced in males, as evidenced by the smaller CBFASL/CBFPC ratio in males (p < 0.05). The measurement of global CBF with PC‐MRI and ASL are correlated, but CBFASL exhibits lower values than CBFPC. As the underestimation of CBFASL is prominent in males, ASL amplifies the sexual dimorphism in CBF compared with PC‐MRI.

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Section: F I G U R Ementioning

confidence: 60%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Range and variability of CBF in young adults: PC‐MRI and ASL studies

Su,

Peng

2023

Int J Imaging Syst Tech

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“…difficult to directly compare, the global CBF values in untrained post-PHV males were similar to middle-aged males in a recent study that quantified global CBF in a similar manner (Tomoto et al, 2023).…”

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confidence: 50%

Habitual exercise in youth: A ʻbrainyʼ idea

Barnes,

Baynard,

Brassard

2023

Experimental Physiology

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The impact of exercise training on cerebrovascular health is a hot topic, with an increasing focus on preventing and delaying neurodegenerative diseases. Yet, there is a paucity of information regarding the effect of habitual exercise on cerebrovascular function, particularly in children and adolescents. This age range is often under-represented in research but can offer important insight concerning the trajectory of health. It is also unclear what the consequences of a lack of habitual exercise are for cerebrovascular health in youth.To address this gap in the literature, in an article in this issue of Experimental Physiology, Talbot et al. investigated both cerebral blood flow (CBF) and cerebrovascular reactivity to carbon dioxide in youth, while accounting for different stages of maturation (using a somatic measure of maturity -predicted age at peak height velocity or PHV) (Talbot, Perkins, Tallon et al., 2023). This study required a considerable number of participants to account for sex, maturation and training status. The authors reported novel findings that endurance-trained youth had higher global CBF at rest (using internal carotid artery (ICA) + vertebral artery blood flow assessments) in comparison to untrained counterparts. In the ʻmatureʼ adolescents, cardiorespiratory fitness was associated with global CBF. Post hoc analysis revealed that untrained post-PHV (or ʻmatureʼ) males demonstrated lower global CBF compared with trained post-PHV males, with no effect of training found in post-PHV females or younger (pre-PHV) groups. Untrained youth were defined as ʻnot taking part in regular exerciseʼ or not meeting established guidelines for physical activity. Although This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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“…181,183,214 Under normal conditions, CBF gradually declines with increasing age in both men and women. 189,215 This decline can be accelerated in the presence of hypertension 26,[216][217][218] or conditions such as heart failure. 160 Based primarily on temporal relationships, many studies have suggested that reductions in CBF begin before the onset of cognitive decline but are accelerated in the presence of hypertension (Figure 1).…”

Section: Cerebral Blood Flowmentioning

confidence: 99%

Hypertension: Causes and Consequences of Circadian Rhythms in Blood Pressure

Faraci,

Scheer

2024

Circulation Research

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Hypertension is extremely common, affecting approximately 1 in every 2 adults globally. Chronic hypertension is the leading modifiable risk factor for cardiovascular disease and premature mortality worldwide. Despite considerable efforts to define mechanisms that underlie hypertension, a potentially major component of the disease, the role of circadian biology has been relatively overlooked in both preclinical models and humans. Although the presence of daily and circadian patterns has been observed from the level of the genome to the whole organism, the functional and structural impact of biological rhythms, including mechanisms such as circadian misalignment, remains relatively poorly defined. Here, we review the impact of daily rhythms and circadian systems in regulating blood pressure and the onset, progression, and consequences of hypertension. There is an emphasis on the impact of circadian biology in relation to vascular disease and end-organ effects that, individually or in combination, contribute to complex phenotypes such as cognitive decline and the loss of cardiac and brain health. Despite effective treatment options for some individuals, control of blood pressure remains inadequate in a substantial portion of the hypertensive population. Greater insight into circadian biology may form a foundation for novel and more widely effective molecular therapies or interventions to help in the prevention, treatment, and management of hypertension and its related pathophysiology.

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Cerebral blood flow and cerebrovascular resistance across the adult lifespan: A multimodality approach

Cited by 10 publications

References 63 publications

Range and variability of CBF in young adults: PC‐MRI and ASL studies

Range and variability of CBF in young adults: PC‐MRI and ASL studies

Habitual exercise in youth: A ʻbrainyʼ idea

Hypertension: Causes and Consequences of Circadian Rhythms in Blood Pressure

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