1986
DOI: 10.1097/00004872-198606000-00018
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Cerebral Blood Flow and Antihypertensive Treatment with Enalapril

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Cited by 26 publications
(6 citation statements)
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“…This absence of effect on baseline cerebral blood flow has also been previously observed with cilazapril, 21 captopril, 30 -31 and enalapril. 32 In contrast, during seizures, vasodilation of the cerebral vasculature is maximal. 25 - 26 There is no more active vascular tone.…”
Section: Discussionmentioning
confidence: 99%
“…This absence of effect on baseline cerebral blood flow has also been previously observed with cilazapril, 21 captopril, 30 -31 and enalapril. 32 In contrast, during seizures, vasodilation of the cerebral vasculature is maximal. 25 - 26 There is no more active vascular tone.…”
Section: Discussionmentioning
confidence: 99%
“…Two separate studies have examined the effect of prolonged treatment schedules on CBF. Enalapril administered daily (10-80 mg) 179S for 8 weeks to patients with chronic hypertension did not change CBF as measured by the intravenous xenon-133 method (Frei & Muller-Brand, 1986). Treatment with captopril for 7 days did not change CBF as measured by xenon-133 inhalation technique (Minematsu et al, 1987).…”
Section: Chronic Arterial Hypertensionmentioning
confidence: 92%
“…The effect of a single oral dose of captopril (25-50 mg) on CBF autoregulation was recently investigated in patients with chronic arterial hypertension as well as in normotensive volunteers (Waldemar et al, 1989c (Frei & Muller-Brand, 1986). Treatment with captopril for 7 days did not change CBF as measured by xenon-133 inhalation technique (Minematsu et al, 1987).…”
Section: Clinical Studies Chronic Arterial Hypertensionmentioning
confidence: 99%
“…From a theoretical point of view, cerebral blood flow autoregulation makes the cerebral circulation independent from the underlying hemodynamic conditions. From a clinical point of view, it has been established in healthy volunteers (Waldemar et al, 1989;Schmidt et al, 1990) and in hypertensive patients (Frei and Muller-Brand, 1986;Minematsu et al, 1987;Waldemar et al, 1989) that ACEIs do not change cerebral blood flow. However, these data have been obtained by invasive (oxygen arterio-venous difference) or radioactive ('33Xe dynamic single-photon-emission-computerized-tomography) techniques which did not easily allow repeated measurements and hence the kinetic assessment of drugs' effects on cerebral blood flow.…”
Section: Discussionmentioning
confidence: 99%
“…It has been established, from experimental (Richer er al, 1986) as well as from clinical studies (Richer et ul, 1987;Bellissant et al, 1992) that the ACEIs-induced vasodilatation is inhomogeneous, preferentially affecting some vascular beds. For example, ACEIs increase the blood flows of the brachial artery Bellissant et al, 1992), and of the common carotid artery in healthy volunteers (Richer er al, 1987;DCmolis et al, 1992DCmolis et al, , 1993b and in hypertensive patients (Safar et al, 1986) but in contrast, they appear not to affect the baseline cerebral blood flow (Frei and Muller-Brand, 1986;Waldemar er al, 1989; al, 1990), as expected because of its autoregulation. However, the methods classically used for determination of cerebral hemodynamics are invasive (oxygen arteriovenous difference) or require the use of radioactive compounds ( '"'Xe clearance measurements) and thus they d o not easily allow repeated measurements.…”
Section: Introductionmentioning
confidence: 93%