Cerebral astrocytomas: histopathologic correlation of MR and CT contrast enhancement with stereotactic biopsy.

Earnest, Franklin; Kelly, Patrick J.; Scheithauer, Bernd W.; Kall, Bruce A.; Cascino, Terrence L.; Ehman, Richard L.; Forbes, Glenn S.; Axley, P L

doi:10.1148/radiology.166.3.2829270

Cited by 331 publications

(119 citation statements)

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“…However, the relationships between histological findings and the signal intensity changes according to the scanning technique employed must be clarified to determine the extent of tumor resection. For example, areas of neovascularization and endothelial proliferation appear as regions enhanced by gadolinium-DTPA, 8) and tumor cell infiltration is located within the area of high signal intensity on T 2 -weighted fast SE imaging. 10) Such issues have not yet been fully investigated.…”

Section: Discussionmentioning

confidence: 99%

Fast Inversion Recovery Magnetic Resonance Imaging with the Real Reconstruction Method: A Diagnostic Tool for Cerebral Gliomas.

Bandai

Tsunoda

Mitsuoka

et al. 2002

Neurol. Med. Chir.(Tokyo)

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The fast inversion recovery (IR) technique was evaluated for the localization of gliomas. Fast IR imaging with real reconstruction and T 1 -weighted spin echo (SE) imaging before and after contrast administration were performed in 20 patients with gliomas. The tumor-to-white matter contrast ratio (TWCR), tumor-to-gray matter contrast ratio (TGCR), tumor-to-white matter contrast-to-noise ratio (TWCNR), and tumor-to-gray matter contrast-to-noise ratio (TGCNR) were calculated and compared. Fast IR imaging visualized tumors with significantly higher TWCR, TGCR, TWCNR, and TGCNR values (p º 0.01) than those for T 1 -weighted SE imaging. In particular, fast IR imaging clearly revealed seven nonenhanced tumors that were poorly visualized on T 1 -weighted SE imaging. Fast IR imaging showed a similar TGCR and significantly higher TWCR (p º 0.01) compared to T 1 -weighted SE imaging with contrast medium in 13 enhanced tumors. However, fast IR imaging showed similar TWCNR and lower TGCNR compared to T 1 -weighted SE imaging with contrast medium. The fast IR technique can discriminate tumors from normal cerebral tissues with high contrast and without the use of contrast medium. This technique is extremely useful for the localization of non-enhanced tumors.

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Section: Discussionmentioning

confidence: 99%

Fast Inversion Recovery Magnetic Resonance Imaging with the Real Reconstruction Method: A Diagnostic Tool for Cerebral Gliomas.

Bandai

Tsunoda

Mitsuoka

et al. 2002

Neurol. Med. Chir.(Tokyo)

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“…The enhancing portion of the lesions corresponds to regions where the blood brain barrier was disrupted and was often highly vascularized (8). Regions of contrast enhancement have also been reported to correlate with areas of malignant neovascularity and endothelial proliferation (9,10).…”

Section: Introductionmentioning

confidence: 98%

“…For gliomas, the extent of tumor is often larger than the Gadolinium enhancing region and isolated tumor cells have been found within intact white matter outside contrast enhancement (9). Although the high signal intensity on T2 weighted images is typically larger than the enhancing region, it cannot be considered representative of the lesion because it does not differentiate between tumor and edema.…”

Section: Introductionmentioning

confidence: 99%

Perfusion, diffusion and spectroscopy values in newly diagnosed cerebral gliomas

et al. 2006

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Purpose To evaluate perfusion, diffusion, and spectroscopy values in enhancing and non-enhancing lesions for patients with newly diagnosed gliomas of different grades. Materials and Methods Sixty-seven patients with newly diagnosed glioma were entered into the study 20 grade II, 26 grade III and 21 grade IV. MR data were acquired at 1.5T and included diffusion weighted images (59/67 patients), dynamic perfusion weighted images (30/67 patients) and 3D H-1 MR spectroscopy (64/67 patients). Enhancing and non-enhancing lesions were delineated by a neuroradiologist and applied to maps of relative cerebral blood volume (rCBV), apparent diffusion coefficient (ADC), relative anisotropy (RA) and metabolite intensities. Results The median rCBV within enhancing regions of grade IV gliomas was significantly elevated relative to enhancing regions in grade III gliomas and normal brain. ADC was elevated relative to normal brain, but was not significantly different between grades or between enhancing and non-enhancing regions. The RA was higher in the non-enhancing region of grade IV gliomas relative to grade II and grade III. Levels of lactate plus lipid were significantly elevated in grade IV relative to grade II and grade III gliomas. Both enhancing and non-enhancing regions in grade IV gliomas showed significant correlations between CBV, ADC and choline levels. Conclusion The data were consistent with grade IV gliomas having higher membrane turnover, increased cell density and increased vascularity within enhancing lesions. Analysis of the correlations among parameters within grade IV gliomas suggested that high vascularity (high rCBV) was correlated with increased cellularity (low ADC) and increased membrane turnover (high choline) in these lesions. The non-enhancing region of grades II and III gliomas had MR parameters consistent with increased cellularity and/or membrane turnover.

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“…Male to female ratio is 3:2 Glioblastoma Multiforme (GBM) are more common in elderly (10). All GBM are associated with oedema, necrosis intralesional haemorrhage and tumor margin are indistinct and they stand out using IV contrast (11,12,13) . Butterfly GBM can extend across corpus callosum (fig -4) Second common intra axial neoplasm was metastases (fig -2).…”

Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Imaging in Evaluation of Intracranial Tumors: A Prospective Study in A Tertiary Hospital

Gogi¹

2017

JMSCR

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Cerebral astrocytomas: histopathologic correlation of MR and CT contrast enhancement with stereotactic biopsy.

Cited by 331 publications

References 0 publications

Fast Inversion Recovery Magnetic Resonance Imaging with the Real Reconstruction Method: A Diagnostic Tool for Cerebral Gliomas.

Fast Inversion Recovery Magnetic Resonance Imaging with the Real Reconstruction Method: A Diagnostic Tool for Cerebral Gliomas.

Perfusion, diffusion and spectroscopy values in newly diagnosed cerebral gliomas

Magnetic Resonance Imaging in Evaluation of Intracranial Tumors: A Prospective Study in A Tertiary Hospital

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