Cerebral arterial and venous blood flow in adolescent multiple sclerosis patients and age‐matched controls using phase contrast MRI

Macgowan, Christopher K.; Chan, Katherine; Laughlin, Suzanne; Marrie, Ruth Ann; Banwell, Brenda

doi:10.1002/jmri.24388

Cited by 13 publications

(14 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The right and left vein flow values were IJV=342 ± 180 and 190 ± 131 ml/min respectively and did not differ significantly from the corresponding flow values recorded in healthy volunteers. Similar results were reported in the study by Rodger, as discussed above [19,25].…”

Section: Discussionsupporting

confidence: 91%

The Hemodynamics of Blood Flow through the Internal Jugular Veins after CCSVI Endovascular Treatment and its Impact on the Quality of Life in Patients with Chronic Cerebrospinal Venous Insufficiency

Kostecki¹,

Zaniewski²

2016

Brain Disord Ther

View full text Add to dashboard Cite

Objectives: The aim of the study was to compare pre-and post-operative blood flow through the internal jugular veins (IJVs) in patients with multiple sclerosis and chronic cerebrospinal venous insufficiency, who were subjected to endovascular treatment. The results were correlated with respect to changes in the quality of life. Methods: 144 MS patients underwent endovascular treatment of the IJVs. The blood flow through the IJVs was assessed by the means of the Doppler ultrasonography. The clinical neurological evaluation was based on the various diagnostic tools (scales). The assessment of the blood flow through the IJVs and an evaluation of the quality of life changes were performed before surgery, and at 1, 3 and 6 months after surgery. Results: A statistically significant increase in the blood flow through the IJVs was identified on both sides during all three postoperative controls. The relationship between the IJV flow changes and the parameters related to the quality of life assessment, a statistically significant positive correlation between the flow improvement in the right IJV and Multiple Sclerosis Impact Scale, as well as Fatigue Severity Scale scores, were found. For the remaining evaluated scales (Expanded Disability Status Scale, Heat Intolerance Scale and Epworth Sleepiness Scale), as well for the flow in the left IJV, there were no statistically significant correlations confirmed. Conclusion: Despite a significant improvement in the blood flow through the IJVs after endovascular interventions on the IJVs in CCSVI patients, it has not demonstrated that hemodynamic changes improve the quality of life in MS patients.

show abstract

Section: Discussionsupporting

confidence: 91%

The Hemodynamics of Blood Flow through the Internal Jugular Veins after CCSVI Endovascular Treatment and its Impact on the Quality of Life in Patients with Chronic Cerebrospinal Venous Insufficiency

Kostecki¹,

Zaniewski²

2016

Brain Disord Ther

View full text Add to dashboard Cite

show abstract

“…In MS the arterial stroke volume was increased by 26 % and the compliance as measured by the AVD was reduced by 35 % compared to the normal young, suggesting the possibility of an increased pulse pressure in the subarachnoid space in MS. The literature provides some evidence for this, the estimated peak-to-peak pulse pressure gradient in the spinal canal in MS patients was noted to be doubled compared to controls [ 44 ] and the pulse volumes were significantly increased in the epidural veins in the spine in adolescents with MS [ 45 ] suggesting an increase in spinal pulse pressure.…”

Section: Discussionmentioning

confidence: 99%

A comparison between the pathophysiology of multiple sclerosis and normal pressure hydrocephalus: is pulse wave encephalopathy a component of MS?

Bateman

Lechner‐Scott

Lea

2016

Fluids Barriers CNS

View full text Add to dashboard Cite

BackgroundIt has been suggested there is a chronic neurodegenerative disorder, underlying the pathophysiology of multiple sclerosis (MS), which is distinct from the more obvious immune-mediated attack on the white matter. Limited data exists indicating there is an alteration in pulse wave propagation within the craniospinal cavity in MS, similar to the findings in normal pressure hydrocephalus (NPH). It is hypothesized MS may harbor pulse wave encephalopathy. The purpose of this study is to compare blood flow and pulse wave measurements in MS patients with a cohort of NPH patients and control subjects, to test this hypothesis.MethodsTwenty patients with MS underwent magnetic resonance (MR) flow quantification techniques. Mean blood flow and stroke volume were measured in the arterial inflow and venous out flow from the sagittal (SSS) and straight sinus (ST). The arteriovenous delay (AVD) was defined. The results were compared with both age-matched controls and NPH patients.ResultsIn MS there was a 35 % reduction in arteriovenous delay and a 5 % reduction in the percentage of the arterial inflow returning via the sagittal sinus compared to age matched controls. There was an alteration in pulse wave propagation, with a 26 % increase in arterial stroke volume but 30 % reduction in SSS and ST stroke volume. The AVD and blood flow changes were in the same direction to those of NPH patients.ConclusionsThere are blood flow and pulsation propagation changes in MS patients which are similar to those of NPH patients. The findings would be consistent with an underlying pulse wave encephalopathy component in MS.Electronic supplementary materialThe online version of this article (doi:10.1186/s12987-016-0041-2) contains supplementary material, which is available to authorized users.

show abstract

“…CBF was measured according to a previously published technique consisting of a single cine PC acquisition prescribed perpendicular to both internal carotid arteries and the basilar artery (BA) at the level of the clivus. 13,14 The following scan parameters were used: echo time ¼ 4.4 ms, field of view ¼ 150 mm, matrix size ¼ 150 3 112, slice thickness ¼ 4 mm, temporal resolution ¼ 14.3 ms, number of signal averages ¼ 1, velocity encoding ¼ 150 cm/s giving an in-plane resolution of 0.6 3 0.6 mm, and an acquisition time of 1 minute, 7 seconds. CBF volume was quantified with a commercial postprocessing tool (QFlow version 5.6; Medis, Leiden, The Netherlands).…”

Section: Cbf and Cdomentioning

confidence: 99%

Cerebral oxygen delivery is reduced in newborns with congenital heart disease

Lim

Kingdom

Saini

et al. 2016

The Journal of Thoracic and Cardiovascular Surgery

View full text Add to dashboard Cite

show abstract

Cerebral arterial and venous blood flow in adolescent multiple sclerosis patients and age‐matched controls using phase contrast MRI

Abstract: No population difference in flow rate was detected in adolescent MS participants relative to age-matched controls.

Cited by 13 publications

References 25 publications

The Hemodynamics of Blood Flow through the Internal Jugular Veins after CCSVI Endovascular Treatment and its Impact on the Quality of Life in Patients with Chronic Cerebrospinal Venous Insufficiency

The Hemodynamics of Blood Flow through the Internal Jugular Veins after CCSVI Endovascular Treatment and its Impact on the Quality of Life in Patients with Chronic Cerebrospinal Venous Insufficiency

A comparison between the pathophysiology of multiple sclerosis and normal pressure hydrocephalus: is pulse wave encephalopathy a component of MS?

Cerebral oxygen delivery is reduced in newborns with congenital heart disease

Contact Info

Product

Resources

About