Cerebral and meningeal multiple myeloma after autologous stem cell transplantation. A case report and review of the literature

Petersen, Solveig; Wagner, Aase; Gimsing, Peter

doi:10.1002/(sici)1096-8652(199912)62:4<228::aid-ajh5>3.0.co;2-3

Cited by 78 publications

(108 citation statements)

References 37 publications

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“…We found only eight cases of CNS-MM diagnosed by means of flow cytometry. 8,15,16,18,20,[22][23][24] Thus, in the current paper we report both our experience and a review of previous cases investigated by flow cytometric methods.…”

Section: Introductionsupporting

confidence: 89%

“…We found that a total number of 187 cases had been reported until 2012. [3][4][5][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] The same case was described in two different instances. 19,23 Therefore, we reviewed review articles and single case reports in order to obtain more information about patients characteristics, the method used to detect plasma cells in the CSF and plasma cell phenotype.…”

Section: Introductionmentioning

confidence: 99%

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Myelomatous Meningitis Evaluated by Multiparameter Flow Cytometry : Report of a Case and Review of the Literature

Marini

Carulli

Lari

et al. 2014

J Clin Exp Hematopathol

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Central nervous system (CNS) involvement in multiple myeloma (MM) is uncommon. Among its possible presentations, leptomeningeal involvement of MM, also termed central nervous system myelomatosis (CNS-MM) is rare and is characterized by the presence of neoplastic plasma cells in the cerebrospinal fluid (CSF). So far, 187 cases of CNS-MM have been reported : the great majority of them were diagnosed by cytological assays and flow cytometry was used in only eight cases. We describe a case of CNS-MM in a 62-year-old woman, previously treated with chemotherapy (VTD) and autologous peripheral blood hematopoietic stem cell transplantation for stage IIIB IgG-l MM. After achieving a very good partial response, the patient showed progression of disease, with an extramedullary localization. During administration of second-line therapy, the patient showed severe neurological symptoms. MRI resulted negative. Diagnosis of CNS-MM was made by multiparameter flow cytometry, which showed the presence of CD56 + plasma cells in a CSF sample, in the absence of plasma cell leukemia. In this paper we also present a review of the eight previous cases of CNS-MM diagnosed by flow cytometry. We found that the application of flow cytometry in cases of MM with neurological symptoms allows a rapid diagnosis of CNS-MM and provides useful information about plasma cell phenotype (including CD56 expression). Some cases of CNS-MM are characterized by normal MRI. In addition, some evidences deriving from the review of literature suggest that CSF monitoring by flow cytometry in such cases might be used to evaluate the efficacy of drugs capable of crossing the blood-brain barrier. 〔J Clin Exp Hematop 54 (2) : 129-136, 2014〕

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Section: Introductionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Myelomatous Meningitis Evaluated by Multiparameter Flow Cytometry : Report of a Case and Review of the Literature

Marini

Carulli

Lari

et al. 2014

J Clin Exp Hematopathol

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“…[2][3][4][5][6][7][8] Often, transient neurological improvement is seen, but progression and death inevitably follow shortly after.…”

mentioning

confidence: 99%

Effective treatment of leptomeningeal multiple myeloma with total craniospinal irradiation supported by second allogeneic donor stem cell infusion

Quach

Ryan

Ganju

et al. 2004

Bone Marrow Transplant

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“…Treatment options include intrathecal chemotherapy, systemic chemotherapy, cranial irradiation or a combination. The prognosis of CNS multiple myeloma is poor, with an overall median survival from the time of diagnosis to death of 2.0 months (range 0.1-25 months) [2].…”

Section: Discussionmentioning

confidence: 99%

Intracranial plasmacytoma as an initial presentation of multiple myeloma

et al. 2010

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AbstractIntra-cranial involvement is an uncommon complication of multiple myeloma. We report a 68-year-old woman hospitalized for acute renal failure, vertigo and headache. Magnetic Resonance Imaging (MRI) revealed two and a half and 3cm length cranial lesion, which proved to be plasmacytoma. After complete staging, we retained the diagnosis of immunoglobulin G lambda-type multiple myeloma with intracranial involvement. Cytogenetic analysis of plasma cells detected no change. Currently, she is a regular hemodialysis patient. She is planned to have both systemic therapy with 40mg dexamethasone and cranial radiotherapy. Involvement of the CNS in multiple myeloma is very rare. Diagnosis of multiple myeloma subsequent to initial intrcranial involvement is confined to exceptional cases. Despite aggressive systemic treatments, including autologous stem cell transplantation and local treatments such as cerebral radiotherapy, the prognosis for patients with CNS myeloma is extremely poor. Our unique case implies that physicians should be alert in case of vertigo or headache in cases with acute renal failure.

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Cerebral and meningeal multiple myeloma after autologous stem cell transplantation. A case report and review of the literature

Cited by 78 publications

References 37 publications

Myelomatous Meningitis Evaluated by Multiparameter Flow Cytometry : Report of a Case and Review of the Literature

Myelomatous Meningitis Evaluated by Multiparameter Flow Cytometry : Report of a Case and Review of the Literature

Effective treatment of leptomeningeal multiple myeloma with total craniospinal irradiation supported by second allogeneic donor stem cell infusion

Intracranial plasmacytoma as an initial presentation of multiple myeloma

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