Cerebral and mediastinal abscesses caused by Nocardia asiatica in an hiv-infected patient

Azevedo, Francisco Kennedy Scofoni Faleiros de; Dutra, Valéria; Souto, Francisco José Dutra

doi:10.1590/0037-8682-0485-2018

Cited by 3 publications

(2 citation statements)

References 3 publications

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“…A higher risk of nocardial cerebral abscess challenged individuals with immunosuppression owing to diabetes mellitus, malignancy, solid organ transformation, corticosteroid treatment, HIV/AIDS, and autoimmune disease. 5,[14][15][16][20][21][22][24][25][26][28][29][30][31][32][33][34] No obvious immunosuppression was seen in the patient we described, the chronic inflammatory owing to aging within patient might partly explain the occurrence of nocardiosis, leading to the immunocompromised status. 6 In general, the clinical diagnosis of nocardiosis is extremely challenged due to nonspecific and insidious characteristics compared with other bacterial infections.…”

Section: Discussionmentioning

confidence: 58%

Cerebral Abscess Infected by Nocardia gipuzkoensis

Li,

Feng,

et al. 2023

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Nocardia gipuzkoensis is a novel species that solely identified in patients with pulmonary infections by far. Growing evidence showed the excellent performance of metagenomics next-generation sequencing (mNGS) on pathogenic identification, especially for new species. Here, we described the first case of an elderly female patient suddenly suffering from neurological disorders owing to N. gipuzkoensis infection. And linezolid could effectively treat N. gipuzkoensis infection. Patients and Methods:The results of imaging, laboratory cultures, and mNGS, as well as therapeutic process are shared. Results: An elderly female patient suddenly suffered from neurological disorders with dysphasia and right limb trembles under no obvious causes. Subsequently, she was diagnosed as intracranial space-occupying lesions by magnetic resonance imaging (MRI). The isolate from brain secretion was further identified as N. gipuzkoensis through mNGS. The targeted therapy with linezolid according to the antimicrobial susceptibility was used to treat cerebral abscess induced by N. gipuzkoensis. During the follow-up, no relapse was observed for the patient after surgery for 104 days. Conclusion: Cerebral abscess induced by N. gipuzkoensis is rare disorder with high mortality. mNGS has been identified as a promising tool in pathogen diagnosis for timely therapy. Linezolid as one of the antimicrobial drugs could effectively treat N. gipuzkoensis infection and prevent adverse outcomes.

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Section: Discussionmentioning

confidence: 58%

Cerebral Abscess Infected by Nocardia gipuzkoensis

Li,

Feng,

et al. 2023

IDR

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“…N. asiatica is a rare Nocardia species that was newly identified in 2004. There are few reports describing N. asiatica infections, including respiratory infections such as pneumonia and mediastinal infections ( 11 , 12 ). We conducted a systematic review of relevant articles in the Medline database using the term “ Nocardia asiatica .” We identified a total of 24 articles, including 15 case reports of N. asiatica infections ( Table 3 ).…”

Section: Discussionmentioning

confidence: 99%

Adult T Cell Leukemia/Lymphoma Becoming Apparent during Treatment of Pulmonary Abscess and Empyema Caused by <i>Nocardia asiatica</i>: A Case Report and Review of the Literature

et al. 2022

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Nocardia is a Gram-positive bacterium that causes opportunistic infections. Nocardia asiatica was newly isolated in 2004, and there have been no case reports describing the empyema caused by N. asiatica. Adult T-cell leukemia/lymphoma (ATL) is a peripheral T-cell malignancy caused by human T-cell leukemia virus type 1 (HTLV-1). We herein report a case in which immunosuppression attributable to ATL may have led to pulmonary abscess and empyema caused by N. asiatica. Our case demonstrates the need to investigate causes of immunosuppression, including ATL, in patients showing nocardiosis.

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