Cerebral activation effects of acupuncture using Zusanli (ST36) and Yanglingquan (GB34) points based on Regional Homogeneity indices: A resting-state fMRI study

Liu, Liansheng; Wu, Yuefeng; Zheng, Jiayi; Lai, Xinsheng; Zeng, Daohui; Hengguo, Li; Shi, Changzheng; Yang, Mei; Chen, Liang

doi:10.3233/xst-160557

Cited by 8 publications

(9 citation statements)

References 31 publications

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“…After analysis, ReHo values of BAs 9 and 31 decreased in LR3+KI3 group versus LR3 group and that of BA13 decreased in LR3+KI3 group versus KI3 group. The deactivation of BAs 9 and 13 was also observed in the study of Liu et al [9] concentrating on the effect of acupoints combination comprising ST36 and GB40 (Yanglingquan) on healthy controls. BAs 9, 13 and 31, partitions of the frontal lobe and the upper posterior cingulate cortex, are mainly connected with cognitive function as well as emotional processing and recognition.…”

Section: Discussionsupporting

confidence: 61%

“…To date, a growing number of Rs-fMRI studies have thrown light on the mechanisms of acupoints combination under healthy state. Based on fMRI, Liu et al found that ST36 (Zusanli) and GB34 (Yanglingquan) together could activate more brain areas and generate new curative effects compared to single acupoint [9]. Chen et al and Cai et al suggested that the change of cerebral regions caused by acupoints combination may be connected with the cooperative integration effect [1, 10].…”

Section: Introductionmentioning

confidence: 99%

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Different Brain Activation after Acupuncture at Combined Acupoints and Single Acupoint in Hypertension Patients: An Rs-fMRI Study Based on ReHo Analysis

Zhang

Cai

Wang

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Background Acupuncture is proved to be effective on hypertension by numerous studies and resting-state functional magnetic resonance imaging (Rs-fMRI) is a widely used technique to study its mechanism. Along with lower blood pressure, patients with hypertension receiving acupuncture also presented improvement in function of cognition, emotion, language, sematic sensation, and so on. This study was a primary study to explore the acting path of acupuncture at combined acupoints in stimulated brain areas related to such functions. Methods In this research, regional homogeneity (ReHo) was applied to analyze the Rs-fMRI image data of brain activities after acupuncture at LR3, KI3, and LR3+KI3 and to compare the differences of functional brain activities between stimulating combined acupoints and single acupoint under pathological conditions. A total of thirty hypertension patients underwent Rs-fMRI scanning before acupuncture treatment and then were randomly divided into three groups following random number table, the LR3 group (3 males and 7 females), the KI3 group (3 males and 7 females), and the LR3+ KI3 group (4 males and 6 females) for needling, respectively. When the 30-min treatment finished, they received a further Rs-fMRI scanning. The Rs-fMRI data before and after the acupuncture treatment were analyzed through ReHo. Results Compared with preacupuncture, respectively, ReHo values increased in Brodmann areas (BAs) 3, 18, and 40 and decreased in BAs 7 and 31 in LR3+ KI3 group. However, ReHo values only decreased in BA7 of KI3 group while the results showed no significant difference of brain regions in LR3 group between pre- and postacupuncture. Compared with LR3 group, LR3+KI3 group exhibited decreased ReHo values in BAs 7, 9, and 31. Meanwhile, compared with KI3 group, LR3+KI3 group exhibited increased ReHo values in the BAs 2, 18, 30, and 40 and decreased ReHo values in BA13. Conclusion Combined acupoints of LR3 and KI3 could act on wider brain areas than the sum of single acupoints, whose functions include emotional processing, cognition, somatic sensation, spatial orientation, language production, and vision.

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Section: Discussionsupporting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Different Brain Activation after Acupuncture at Combined Acupoints and Single Acupoint in Hypertension Patients: An Rs-fMRI Study Based on ReHo Analysis

Zhang

Cai

Wang

et al. 2019

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

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“…With the development of neuroimaging techniques, the use of positron emission tomography (PET) and functional magnetic resonance imaging (MRI) to explore the central mechanism of acupuncture has been an active area of research 32 . Notably, functional MRI studies report that EA stimulation on SMFY and GMFS acupoints contribute to activation of brain regions 33 – 36 . Recent papers have described the central regulations over the benign and comprehensive regulatory effects of acupuncture by brain, and certain findings are similar to the results of the current study.…”

Section: Discussionmentioning

confidence: 99%

1H NMR-based Investigation of Metabolic Response to Electro-Acupuncture Stimulation

Lin

Wei

Cheng

et al. 2017

Sci Rep

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Acupuncture is a traditional Chinese medicine therapy that has been found useful for treating various diseases. The treatments involve the insertion of fine needles at acupoints along specific meridians (meridian specificity). This study aims to investigate the metabolic basis of meridian specificity using proton nuclear magnetic resonance (1H NMR)-based metabolomics. Electro-acupuncture (EA) stimulations were performed at acupoints of either Stomach Meridian of Foot-Yangming (SMFY) or Gallbladder Meridian of Foot-Shaoyang (GMFS) in healthy male Sprague Dawley (SD) rats. 1H-NMR spectra datasets of serum, urine, cortex, and stomach tissue extracts from the rats were analysed by multivariate statistical analysis to investigate metabolic perturbations due to EA treatments at different meridians. EA treatment on either the SMFY or GMFS acupoints induced significant variations in 31 metabolites, e.g., amino acids, organic acids, choline esters and glucose. Moreover, a few meridian-specific metabolic changes were found for EA stimulations on the SMFY or GMFS acupoints. Our study demonstrated significant metabolic differences in response to EA stimulations on acupoints of SMFY and GMFS meridians. These results validate the hypothesis that meridian specificity in acupuncture is detectable in the metabolome and demonstrate the feasibility and effectiveness of a metabolomics approach in understanding the mechanism of acupuncture.

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“…Nierhaus et al [13] considered that the stimulation about ST36 can obviously modulate somatosensory and saliency processing activities than nonacupoint. Liu et al [14] addressed that the combined acupoints activate a wider range of brain areas than single points. In addition, the association of acupoints could activate a few new brain areas and engender new curative effects.…”

Section: Introductionmentioning

confidence: 99%

Resting-State fMRI in Studies of Acupuncture

Cai

Jiang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Research exploring the mechanism of acupuncture has been a hot topic in medicine. Resting-state functional magnetic resonance imaging (rs-fMRI) research is a noninvasive and extensive method, which is aimed at the research of the mechanism of acupuncture. Researchers use fMRI technologies to inspect the acupuncture process. The authors reviewed the application of rs-fMRI in acupuncture research in recent 10 years from the aspects of studying acupoints, subjects, acupuncture methods, and intensities. The results found that the application of rs-fMRI in acupuncture research mainly includes research on the onset mechanism of acupuncture treatment; visual evidence of diagnosis and treatment of dominant diseases; efficacy assessments; physiological mechanism of acupoint stimulation; and specific visualization of acupoints.

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Cerebral activation effects of acupuncture using Zusanli (ST36) and Yanglingquan (GB34) points based on Regional Homogeneity indices: A resting-state fMRI study

Abstract: The results of our neuroimaging study suggest that the combination of acupoints could more widely activate areas of the brain compared to a single acupoint. Additionally, the combination of acupoints can activate some new brain areas and generate new curative effects.

Cited by 8 publications

References 31 publications

Different Brain Activation after Acupuncture at Combined Acupoints and Single Acupoint in Hypertension Patients: An Rs-fMRI Study Based on ReHo Analysis

Different Brain Activation after Acupuncture at Combined Acupoints and Single Acupoint in Hypertension Patients: An Rs-fMRI Study Based on ReHo Analysis

1H NMR-based Investigation of Metabolic Response to Electro-Acupuncture Stimulation

Resting-State fMRI in Studies of Acupuncture

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