Cerebellum in Neurological Disorders: A Review on the Role of Inter-Connected Neural Circuits

Diwakar, Shyam

doi:10.15406/jnsk.2017.06.00196

Cited by 3 publications

(4 citation statements)

References 65 publications

(56 reference statements)

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“…By using a series of bioinformatic tools, we found converging evidence for GCI + and GCI - involvement in cerebellar neurodevelopment and cerebellar neurotransmission, respectively. It is also interesting to speculate that these 443 network-specific genes that link both cerebellar functional segregation and integration have a relationship with some brain-related disorders since prior evidence showed that the cerebellar functional organization plays a key role in various neurological 13,53 and neuropsychiatric disorders 12 , most of which possess common underlying genetic risks 54 . But a tricky problem emerged in that the genes we are interested in were derived from healthy individuals.…”

Section: Discussionmentioning

confidence: 99%

“…It is well known that the macroscale functional organization of the human nervous system is widely accepted as being ultimately regulated by the underlying microscale gene expression (9)(10)(11)(12). Therefore, unraveling the genetic profiles underlying the cerebellar functional organization could help us understand how the cerebellum organizes different functional subregions that have mostly invariant architecture (13) into functional networks that support its engagements in various functions (14) as well as increasing our understanding of its relevance in diverse brain diseases (15,16).…”

Section: Introductionmentioning

confidence: 99%

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Uncovering the Genetic Profiles Underlying the Intrinsic Organization of the Human Cerebellum

Wang

Chai

et al. 2021

Preprint

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Decoding the genetic profiles underlying the cerebellar functional organization is critical for uncovering the essential role of the human cerebellum in various high-order functions and malfunctions in neuropsychiatric disorders. However, no effort has been made to systemically address this. By combining transcriptome data with the intrinsic functional connectivity of the human cerebellum, we not only identified 443 network-specific genes but also discovered that their gene co-expression pattern correlated strongly with intra-cerebellar functional connectivity. Of these genes, 90 were also differentially expressed in the cerebral cortex and linked the cortico-cerebellar cognitive-limbic networks. To further discover the biological functions of these genes, we performed a virtual gene knock-out by observing the change in the coupling between gene co-expression and functional connectivity and divided the genes into two subsets, i.e., a positive gene contribution indicator (GCI+) and a negative gene set (GCI-). GCI+ is mainly involved in cerebellar neurodevelopment, while GCI- is related to neurotransmission and is significantly enriched in various neurological and neuropsychiatric disorders that are closely linked the cerebellar functional abnormalities. Collectively, our results provide new insight into the genetic substrates behind the functional organization of the human cerebellum with relevance to the possible mechanism of cerebellar contributions to related neurological and psychiatric disorders.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Uncovering the Genetic Profiles Underlying the Intrinsic Organization of the Human Cerebellum

Wang

Chai

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…By using a series of bioinformatic tools, we found converging evidence for GCI + and GCIinvolvement in cerebellar neurodevelopment and cerebellar neurotransmission, respectively. It is also interesting to speculate that these 443 network-specific genes that link both cerebellar functional segregation and integration have a relationship with some brain-related disorders since prior evidence showed that the cerebellar functional organization plays a key role in various neurological (16,55) and psychiatric disorders (15), most of which possess common underlying genetic risks (56). But a tricky problem emerged in that the genes we are interested in were derived from healthy individuals.…”

Section: Cerebellar Neurodevelopment Feature Of Gci + Cerebellar Neu...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Uncovering the genetic profiles underlying the intrinsic organization of the human cerebellum

et al. 2022

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The functional diversity of the human cerebellum is hypothesized to be derived more from its extensive connections rather than being limited to its mostly invariant architecture. However, whether and how the hypothesized determination of cerebellar connections in its intrinsic organization interact with microscale gene expression is still unknown. Here we decode the genetic profiles of the cerebellar functional organization by investigating the genetic substrates simultaneously linking cerebellar functional heterogeneity and its drivers, i.e., the connections. We not only identified 443 network-specific genes but also discovered that their co-expression pattern correlated strongly with intra-cerebellar connectivity. Of these genes, 90 were also linked to the cortico-cerebellar cognitive-limbic networks. Then, using a "virtual gene knock-out" analysis, two gene sets involved in different biological processes and diseases were distinguished. Collectively, our results could help to rethink the genetic substrates underlying the cerebellar functional organization, as well as offer possible interpretability for its engagement in neuropsychiatric disorders.

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Mutual information study of modeled neural responses under induced neuronal plasticity

Sreekumar,

Santhosh,

Nair

2023

Recent Advances in Industry 4.0 Technologies

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Cerebellum in Neurological Disorders: A Review on the Role of Inter-Connected Neural Circuits

Cited by 3 publications

References 65 publications

Uncovering the Genetic Profiles Underlying the Intrinsic Organization of the Human Cerebellum

Uncovering the Genetic Profiles Underlying the Intrinsic Organization of the Human Cerebellum

Uncovering the genetic profiles underlying the intrinsic organization of the human cerebellum

Mutual information study of modeled neural responses under induced neuronal plasticity

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