Cerebellum and cognition in multiple sclerosis

Schreck, Laura Marie; Ryan, S. P. P.; Monaghan, Patrick G.

doi:10.1152/jn.00245.2018

Cited by 12 publications

(9 citation statements)

References 13 publications

(16 reference statements)

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“…38 Most of the MRI abnormalities that were reported to have an impact on cognition were either volumetric changes in gray or white matter or functional MRI abnormalities such as total cerebellar volume, cerebellar gray matter volume, cerebellar gray matter volume, hubs and network properties, fractional anisotropy, and voxelbased morphometry abnormalities. [39][40][41][42][43] Data about the impact of total lesion load in cerebellum and cerebellar peduncles on cognition were conflicting. Some authors such as Valentino and colleagues, 37 found no significant correlation between total lesion load in the cerebellum and cognition in a cohort of RRMS patients, whilst Cerasa and colleagues, 44,45 reported the reverse.…”

Section: Discussionmentioning

confidence: 99%

Middle Cerebellar Peduncle Lesions and Their Relation to Affective and Cognitive Impairment in Multiple Sclerosis

Hamdy

Ramadan

Mekky

et al. 2022

Int Clin Neurosci J

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Background: Cerebellum has long been known to modulate not only motor coordination but also affective and cognitive functions. This study aimed to assess the impact of middle cerebellar peduncle (MCP) lesions on affective and cognitive function in patients with multiple sclerosis (MS). Methods: This was a cross-sectional study conducted on patients with relapsing-remitting MS (RRMS). All patients were subjected to 3-Tesla magnetic resonance imaging (3T MRI), brief international cognitive assessment for MS (BICAMS), and Depression, Anxiety, and Stress Score-21 (DASS-21) upon recruitment. Results: Of the 30 patients recruited, 33.3% and 36.7% had right and left MCP lesions, respectively. Patients with right MCP lesions had significantly worse symbol digit modality test (SDMT) scores (P=0.036), worse California verbal learning test (CVLT) immediate recall scores (P=0.011), and worse CVLT delayed free recall scores (P=0.049), whereas patients with left MCP lesions had lower DASS-21 scores (P<0.005). On multivariate regression analysis, the presence of left MCP lesion was associated with an 8.9-point reduction in DASS-21 scores (CI: -16.985- -0.805, P=0.033), whereas right MCP lesions did not have an independent effect on BICAMS scores after adjustment for age and educational level. Conclusion: Left MCP lesions were associated with significantly lower DASS-21 scores, whereas none of the MCP lesions had an independent impact on cognition.

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Section: Discussionmentioning

confidence: 99%

Middle Cerebellar Peduncle Lesions and Their Relation to Affective and Cognitive Impairment in Multiple Sclerosis

Hamdy

Ramadan

Mekky

et al. 2022

Int Clin Neurosci J

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“…Lower cerebral glucose metabolism levels in the FrA and hippocampus related to memory deficits have also been found in our previous PET study ( Park et al, 2013 ; Lim et al, 2016 ; Ye et al, 2016 ). Furthermore, other groups have reported cognitive decline-associated decreases in cerebral glucose metabolism in the Cb ( Schreck et al, 2018 ; Liang and Carlson, 2019 ; Nishida et al, 2019 ). In the current study, the decrease in the cerebral glucose metabolism in the FrA persisted at the 7-month time-point.…”

Section: Discussionmentioning

confidence: 94%

Conductive Hearing Loss Aggravates Memory Decline in Alzheimer Model Mice

Kim

Lee

et al. 2020

Front. Neurosci.

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The study of cognitive impairment associated with hearing loss has recently garnered considerable interest. Epidemiological data have demonstrated that hearing loss is a risk factor for cognitive decline as a result of aging. However, no previous study has examined the effect of hearing loss in patients with cognitive problems such as Alzheimer’s disease. Therefore, we investigated the effect of conductive hearing loss in an Alzheimer’s mouse model. Positron emission tomography (PET) and magnetic resonance imaging (MRI) were used to evaluate changes in glucose metabolism and gray matter concentrations in the 5xFAD Alzheimer’s Disease (AD) transgenic mouse model with and without conductive hearing loss (HL). Conductive hearing loss was induced using chronic perforation of the tympanic membrane. Behavioral data from the Y-maze and passive avoidance tests revealed greater memory deficits in the AD with HL (AD-HL) group than in the AD group. Following induction of hearing loss, lower cerebral glucose metabolism in the frontal association cortex was observed in the AD-HL group than in the AD group. Although lower glucose metabolism in the hippocampus and cerebellum was found in the AD-HL group than in the AD group at 3 months, the gray matter concentrations in these regions were not significantly different between the groups. Furthermore, the gray matter concentrations in the simple lobule, cingulate/retrosplenial cortex, substantia nigra, retrosigmoid nucleus, medial geniculate nucleus, and anterior pretectal nucleus at 7 months were significantly lower in the AD-HL group than in the AD group. Taken together, these results indicate that even partial hearing loss can aggravate memory impairment in Alzheimer’s disease.

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“…In their review on balance improvement, Gunn et al reported a positive influence of exercise interventions on balance in pwMS [113]. Other studies focusing on general motor rehabilitation in pwMS pointed at the issue that motor learning consists of three stages (cognitive, associative and autonomous phase), where the first stage depends on the person's cognitive abilities [114], and the fact that cognitive impairment is very common in pwMS thus connects cognitive and mobility dysfunction [115].…”

Section: Coordination/balancementioning

confidence: 99%

Digital Biomarkers in Multiple Sclerosis

et al. 2021

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For incurable diseases, such as multiple sclerosis (MS), the prevention of progression and the preservation of quality of life play a crucial role over the entire therapy period. In MS, patients tend to become ill at a younger age and are so variable in terms of their disease course that there is no standard therapy. Therefore, it is necessary to enable a therapy that is as personalized as possible and to respond promptly to any changes, whether with noticeable symptoms or symptomless. Here, measurable parameters of biological processes can be used, which provide good information with regard to prognostic and diagnostic aspects, disease activity and response to therapy, so-called biomarkers Increasing digitalization and the availability of easy-to-use devices and technology also enable healthcare professionals to use a new class of digital biomarkers—digital health technologies—to explain, influence and/or predict health-related outcomes. The technology and devices from which these digital biomarkers stem are quite broad, and range from wearables that collect patients’ activity during digitalized functional tests (e.g., the Multiple Sclerosis Performance Test, dual-tasking performance and speech) to digitalized diagnostic procedures (e.g., optical coherence tomography) and software-supported magnetic resonance imaging evaluation. These technologies offer a timesaving way to collect valuable data on a regular basis over a long period of time, not only once or twice a year during patients’ routine visit at the clinic. Therefore, they lead to real-life data acquisition, closer patient monitoring and thus a patient dataset useful for precision medicine. Despite the great benefit of such increasing digitalization, for now, the path to implementing digital biomarkers is widely unknown or inconsistent. Challenges around validation, infrastructure, evidence generation, consistent data collection and analysis still persist. In this narrative review, we explore existing and future opportunities to capture clinical digital biomarkers in the care of people with MS, which may lead to a digital twin of the patient. To do this, we searched published papers for existing opportunities to capture clinical digital biomarkers for different functional systems in the context of MS, and also gathered perspectives on digital biomarkers under development or already existing as a research approach.

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Cerebellum and cognition in multiple sclerosis

Cited by 12 publications

References 13 publications

Middle Cerebellar Peduncle Lesions and Their Relation to Affective and Cognitive Impairment in Multiple Sclerosis

Middle Cerebellar Peduncle Lesions and Their Relation to Affective and Cognitive Impairment in Multiple Sclerosis

Conductive Hearing Loss Aggravates Memory Decline in Alzheimer Model Mice

Digital Biomarkers in Multiple Sclerosis

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