Cerebellotectal projections studied in cats with horseradish peroxidase or tritiated amino acids axonal transport

Hirai, Toshihide; Onodera, Satoru; Kawamura, Koki

doi:10.1007/bf00239567

Cited by 51 publications

(26 citation statements)

References 36 publications

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“…New World monkeys, too, show a similar two-channel cerebello-tectal projection (Gonzalo-Ruiz et al, 1988), suggesting that all primates are similar in this respect. The cat also possesses a fastigio-tectal bilateral pathway, although there is much more in the way of a caudal overlap with the contralaterally projecting interpositus and dentate projection (Hirai et al, 1982). The results so far discussed and the findings of degeneration studies in the opossum (Martin et al, 1974) and hedgehog (Earle and Matzke, 1974) all point to a possible generalization on the basis of eye position and importance of eye-in-head movements.…”

Section: Other Speciesmentioning

confidence: 83%

Excitatory Drive from Deep Cerebellar Neurons to the Superior Colliculus in the Rat: an Electrophysiological Mapping Study

Westby

Collinson

Dean

1993

Eur J of Neuroscience

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The cerebello-tectal projection arising from the interpositus nucleus was investigated electrophysiologically to test the hypothesis that the deep cerebellar nuclei constitute a source of tonic excitation in the superior colliculus. A total of 117 spontaneously active collicular neurons were recorded during GABA microinjection into 26 interpositus sites, where tonic single-cell deep cerebellar activity was also simultaneously recorded. GABA injection always led to suppression of interpositus activity, while in the colliculus a clear pattern of results emerged. 58% of superior colliculus cells showed no response to suppression of interpositus activity, 35% showed a frequency decrease and 7% showed a frequency increase. The majority of these responsive cells were found in a laterally located sheet of cells mainly restricted to the intermediate white layer, in close register with the known cells of origin of the predorsal bundle and completely overlapping the terminals of the nigrotectal pathway originating in dorsolateral substantia nigra pars reticulata. The implications of these results for cooperative theories of head movement control involving the superior colliculus, cerebellum and precerebellar nuclei are discussed.

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Section: Other Speciesmentioning

confidence: 83%

Excitatory Drive from Deep Cerebellar Neurons to the Superior Colliculus in the Rat: an Electrophysiological Mapping Study

Westby

Collinson

Dean

1993

Eur J of Neuroscience

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“…The intralaminar nuclei are known to receive projections from the nucleus interpositus and the lateral nucleus of the cerebellum (Sugimoto et al, 1981;Hirai et al, 1982;Kawamura et al, 1982), and were reported to play a role in eye movement signal processing (Schlag-Rey and Schlag, 1977). It is also well known that the intralaminar nuclei receive projections from the intermediate layer of SC (Graham, 1977).…”

Section: Connectional and Physiological Consideration Of Each Divisiomentioning

confidence: 98%

Cytoarchitectonic and connectional organization of the ventral lateral geniculate nucleus in the cat

Nakamura

Itoh

2004

J of Comparative Neurology

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The ventral lateral geniculate nucleus is a small extrageniculate visual structure that has a complex cytoarchitecture and diverse connections. In addition to small-celled medial and lateral divisions, we cytoarchitectonically defined a small-celled dorsal division. A large-celled intermediate division intercalated between the three small-celled divisions, which we divided into medial and lateral intermediate subdivisions. In WGA-HRP injection experiments, the different cytoarchitectonic divisions were shown to have connections with different nuclei. The medial division was reciprocally connected to the pretectum and projected to the superficial layers of the superior colliculus and the intralaminar nuclei. The medial intermediate division received projections from the intermediate layer of the superior colliculus and the lateral and interpositus posterior cerebellar nuclei, and projected to the intermediate layer of the superior colliculus, the periaqueductal gray of midbrain, and the intralaminar nuclei. The lateral intermediate divisions received projections from the pretectum, the intermediate layer of the superior colliculus, and the lateral and interpositus posterior cerebellar nuclei, and projected to the pretectum, superficial layers of the superior colliculus, and the pulvinar. The lateral division received projections from superficial layers of the superior colliculus and had reciprocal connections with the pretectum. The dorsal division received projections from the pretectum and had reciprocal connections with the periaqueductal gray of midbrain. The different cytoarchitectonic divisions of the ventral lateral geniculate nucleus are thus suggested to play different functional roles related to vision, eye and head movements, attention, and defensive reactions.

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“…All cerebellar nuclei also target the neocortex via thalamic innervation. Connectivity based on Hirai et al (1982), Ito (1984), Gibson et al (1987), Zwergal et al (2009) and Bostan et al (2013). Targeted motor structures in turn overlap in their innervation of the spinal interneuronal motor circuitry (Jankowska, 1992;Bortoff & Strick, 1993;Hultborn, 2001;Hammar et al 2011;Jankowska et al 2011a;Shrestha et al 2012;Spanne & Jörntell, 2013).…”

Section: Figure 1 Schematic Illustration Of the Cerebellar Sagittal mentioning

confidence: 99%

Cerebellar physiology: links between microcircuitry properties and sensorimotor functions

Jörntell

2016

The Journal of Physiology

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Final sensorimotor command Sensory readout Movement commandAbstract Existing knowledge of the cerebellar microcircuitry structure and physiology allows a rather detailed description of what it in itself can and cannot do. Combined with a known mapping of different cerebellar regions to afferent systems and motor output target structures, there are several constraints that can be used to describe how specific components of the cerebellar microcircuitry may work during sensorimotor control. In fact, as described in this review, the major factor that hampers further progress in understanding cerebellar function is the limited insights into the circuitry-level function of the targeted motor output systems and the nature of the information in the mossy fiber afferents. The cerebellar circuitry in itself is here summarized Henrik Jörntell received his PhD degree in Neurophysiology from Lund University. He is currently employed as a senior lecturer at Lund University where he heads the lab 'Neural Basis for Sensorimotor Control' at the Department of Experimental Medical Science. His interests are the neurophysiological analysis of neuronal microcircuits involved in movement control, spanning cerebellar, spinal, brainstem and neocortical circuitry as well as models of how these structures interact during movement performance and motor learning. as a gigantic associative memory element, primarily consisting of the parallel fiber synapses, whereas most other circuitry components, including the climbing fiber system, primarily has the role of maintaining activity balance in the intracerebellar and extracerebellar circuitry. The review explores the consistency of this novel interpretational framework with multiple diverse observations at the synaptic and microcircuitry level within the cerebellum.(Received 9 May 2016; accepted after revision 29 June 2016; first published online 8 July 2016) Email: henrik.jorntell@med.lu.se Abstract figure legendThe cerebellar neuronal circuitry is here summarized as a gigantic associative memory, consisting of multiple functional subunits working in parallel, by which useful contingencies between diverse types of information can be stored. The sources of information are the multiple mossy fiber systems that inform the cerebellum about original motor commands/motor plans and sensorimotor information at different levels of abstraction. The output of each functional subunit of the cerebellum is refining the ongoing movement command by linking learnt appropriate sensorimotor functions for the particular context or state. Because of its size, the memory element can house the appropriate associations, translatable to synaptic weights, relevant for all contexts or states that the individual can be expected to experience during a lifetime. It follows that a key component necessary to further improve our understanding of cerebellar function is a precise knowledge of the types and formats of information that reaches the cerebellum via the vast variety of mossy fiber pathways, a subject area that has ...

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Cerebellotectal projections studied in cats with horseradish peroxidase or tritiated amino acids axonal transport

Cited by 51 publications

References 36 publications

Excitatory Drive from Deep Cerebellar Neurons to the Superior Colliculus in the Rat: an Electrophysiological Mapping Study

Excitatory Drive from Deep Cerebellar Neurons to the Superior Colliculus in the Rat: an Electrophysiological Mapping Study

Cytoarchitectonic and connectional organization of the ventral lateral geniculate nucleus in the cat

Cerebellar physiology: links between microcircuitry properties and sensorimotor functions

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