Cerebellopontine Angle Primary Choroid Plexus Carcinoma Present in an Adult: Case Report and Literature Review

Abstract

Choroid plexus tumors (CPTs) are rare intraventricular neoplasms that primarily occur in children and are rare in adults. Of the CPT subtypes, choroid plexus carcinomas (CPC) are highly aggressive and malignant and of World Health Organization (WHO) Grade III. Dissemination through the cerebrospinal fluid space is the inevitable natural course of the disease. In this case report, we present a 33-year-old female with a past medical history notable for schizophrenia and bipolar disease who suffered from left-sided acute vision loss and hearing loss. Magnetic resonance imaging (MRI) demonstrated multiple enhancing masses found in the left cerebellopontine angle (CPA), right internal auditory canal, the atrium of the left ventricle, and the left foramen of Monroe. After surgical decompression of the CPA tumor, the permanent final pathology was consistent with CPC. To our knowledge, this is the first reported case of a primary CPC occurring within the CPA in an adult. The unique presentation and progression of this rare adult-onset CPC provide insight for the diagnosis and treatment of other rare instances of CPTs.

Intracranial Subdural Fluid Accumulation Associated with a Choroid Plexus Carcinoma in a Dog

“…Post-mortem MRI did not demonstrate a recurrence of the SFA that could have explained the neurological deterioration that the dog developed some weeks after surgery. Clinical signs in CPTs are thought to be most commonly related to a secondary progressive hydrocephalus [ 45 ], a finding that is present in around 75% of dogs with CPT [ 3 ] and that was also identified on post-mortem MRI in our dog and therefore could have caused the worsening of neurological signs. As an intraventricular mass lesion was missing in our dog that could have caused obstruction of the ventricular system, it seems more likely that the hydrocephalus was caused by impairment of CSF production and absorption secondary to the CPC [ 5 , 6 ].…”

Primary adult choroid plexus carcinomas: a single-center experience with a systematic review

“…They exhibit distinct malignant features, such as a high number of mitotic figures, dense cellularity, loss of clear papillary growth pattern, presence of necrosis, and infiltration into the surrounding brain tissue (2). It primarily occurs in children and rarely affects adults (3). An increasing number of studies have delved into the research of pediatric CPCs (4, 5).…”